Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

2024
- Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2024). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology, 602(18), 4585-4604. https://doi.org/10.1113/JP284439
- Rijks, J. H. J., Heckman, L., Westra, S., Cornelussen, R., Ghosh, S., Curila, K., Smisek, R., Grieco, D., Bressi, E., Nguyen, U. C., Lumens, J., van Stipdonk, A. M. W., Linz, D., Prinzen, F. W., Luermans, J. G. L. M., & Vernooy, K. (2024). Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods. Journal of Cardiovascular Electrophysiology, Article 16435. https://doi.org/10.1111/jce.16435
- Beela, A. S., Rijks, J. H. J., Manetti, C. A., Vernooy, K., van Stipdonk, A. M. W., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2024). Left bundle branch block criteria in the 2021 ESC guidelines on CRT: A step back in identifying CRT candidates?European Heart Journal Cardiovascular Imaging, 25(9), e213-e215. https://doi.org/10.1093/ehjci/jeae164
- Koopsen, T., van Osta, N., van Loon, T., Meiburg, R., Huberts, W., Beela, A. S., Kirkels, F. P., van Klarenbosch, B. R., Teske, A. J., Cramer, M. J., Bijvoet, G. P., van Stipdonk, A., Vernooy, K., Delhaas, T., & Lumens, J. (2024). Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination. Biomedical Engineering Online, 23(1), Article 46. https://doi.org/10.1186/s12938-024-01232-0
- Arts, T., Lyon, A., Delhaas, T., Kuster, D. W. D., van der Velden, J., & Lumens, J. (2024). Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model. Journal of Molecular and Cellular Cardiology, 190, 13-23. https://doi.org/10.1016/j.yjmcc.2024.03.001
- Dhont, S., van den Acker, G., van Loon, T., Verbrugge, F. H., Verwerft, J., Deferm, S., Churchill, T. W., Mullens, W., Lumens, J., & Bertrand, P. B. (2024). Mitral regurgitation in heart failure with preserved ejection fraction: The interplay of valve, ventricle, and atrium. European journal of heart failure, 26(4), 974-983. https://doi.org/10.1002/ejhf.3231
- Ložek, M., Kovanda, J., Kubuš, P., Vrbík, M., Lhotská, L., Lumens, J., Delhaas, T., & Janoušek, J. (2024). How to assess and treat right ventricular electromechanical dyssynchrony in post-repair tetralogy of Fallot: insights from imaging, invasive studies and computational modelling. EP Europace, 26(2), Article euae024. https://doi.org/10.1093/europace/euae024
- Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
- Eerenberg, F., Luermans, J., Lumens, J., Nguyên, U. C., Vernooy, K., & van Stipdonk, A. (2024). Exploring QRS Area beyond Patient Selection in CRT-Can It Guide Left Ventricular Lead Placement?Journal of Cardiovascular Development and Disease, 11(1), Article 18. https://doi.org/10.3390/jcdd11010018
- Munneke, A. G., Lumens, J., & Delhaas, T. (2024). Diagnostic value of reversed differential cyanosis in (supra)cardiac total anomalous pulmonary venous return. Pediatric Research. Advance online publication. https://doi.org/10.1038/s41390-024-03355-5

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Joost Lumens

Professor