Julie Staals

Professor

Prof. Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

Julie Staals has been appointed as professor 'Neurovascular disease' as of 1 April 2024. Julie is neurologist at Maastricht UMC+ and leader of the stroke clinic. Her research aims at unravelling the pathophysiology of cerebral small vessel disease, a common ageing-related disease leading to stroke and dementia, which falls within the research programs of both CARIM and MHeNS. Furthermore she is involved in clinical studies on the very successfull acute endovascular stroke treatment. The inaugural lecture will follow later.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)

Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

2025
- Ruthmann, F., Lo, J. W., Mendyk-Bordet, A.-M., Allart, E., Köhler, S., Klimkowicz-Mrowiec, A., Staals, J., Sachdev, P. S., Bordet, R., Dondaine, T., & Stroke and Cognition (STROKOG) Collaboration (2025). Prevalence of poststroke anxiety and its associations with global cognitive impairment: An individual participant data analysis. Journal of Affective Disorders, 369, 1136-1144. Advance online publication. https://doi.org/10.1016/j.jad.2024.10.099
2024
- Robbe, M. M. Q., Pinckaers, F. M. E., Wagemans, B. A. J. M., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2024). Additional value of CTP maps in occlusion detection on CTP angiographic reconstructions for ischemic stroke. European Journal of Radiology, 181, Article 111789. https://doi.org/10.1016/j.ejrad.2024.111789
- Peeters, M. T. J., Postma, A. A., van Oostenbrugge, R. J., Henneman, W. J. P., & Staals, J. (2024). Dual-energy CT angiography in detecting underlying causes of intracerebral hemorrhage: an observational cohort study. Neuroradiology. https://doi.org/10.1007/s00234-024-03473-1
- Fandler-Höfler, S., Eppinger, S., Ambler, G., Nash, P., Kneihsl, M., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martínez-Domeño, A., Inamura, S., Yoshifuji, K., ... Microbleeds International Collaborative Network (2024). Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds. Jama network open, 7(10), Article e2439571. https://doi.org/10.1001/jamanetworkopen.2024.39571
- Coenen, M., de Kort, F. A. S., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Bordet, R., Chen, C. L., Dewenter, A., Doeven, T., Dondaine, T., Duering, M., Fang, R., van der Giessen, R. S., Kim, J., Kim, B. J., de Kort, P. L. M., Koudstaal, P., Lee, M., ... Biesbroek, J. M. (2024). Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment: a multicenter study in 1568 stroke patients. International journal of stroke, 19(8), 916-924. https://doi.org/10.1177/17474930241252530
- van Dinther, M., Voorter, P. H. M., Zhang, E., van Kuijk, S. M. J., Jansen, J. F. A., van Oostenbrugge, R. J., Backes, W. H., & Staals, J. (2024). The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach. Geroscience, 46(5), 5061-5073. https://doi.org/10.1007/s11357-024-01235-8
- Knapen, R. R. M. M., Goldhoorn, R.-J. B., Hofmeijer, J., Lycklamaa Nijeholt, G. J., van den Berg, R., van den Wijngaard, I. R., van Oostenbrugge, R. J., van Zwam, W. H., van der Leij, C., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Hinsenveld, W., Staals, J., Postma - Jacobi, L., Brans, R., Olthuis, S., & Pinckaers, F. (2024). Balloon Guide Catheter Versus Non-Balloon Guide Catheter: A MR CLEAN Registry Analysis. Stroke: vascular and interventional neurology, 4(4), Article e001103. https://doi.org/10.1161/SVIN.123.001103
- Starmans, N. L. P., Wolters, F. J., Leeuwis, A. E., Bron, E. E., de Bresser, J., Brunner-La Rocca, H. P., Staals, J., Muller, M., Biessels, G. J., Kappelle, L. J., & Heart-Brain Connection Consortium (2024). Orthostatic hypotension, cognition and structural brain imaging in hemodynamically impaired patients. Journal of the Neurological Sciences, 461, Article 123026. https://doi.org/10.1016/j.jns.2024.123026
- Van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H., Marquering, H. A., De Jong, H. W. A. M., Berkhemer, O. A., Van Zwam, W. H., Van Walderveen, M. A. A., Van Den Wijngaard, I. R., Dippel, D. W. J., Yoo, A. J., Campbell, B., Kunz, W. G., Majoie, C. B., Emmer, B. J., ... MR CLEAN Registry Investigators (2024). Costs and health effects of CT perfusion-based selection for endovascular thrombectomy within 6 hours of stroke onset: a model-based health economic evaluation. Journal of Neurology Neurosurgery and Psychiatry, 95(6), 515-527. https://doi.org/10.1136/jnnp-2023-331862
- van der Knaap, N., de Vreeze, F., van Rosmalen, F., Wintjens, M. S. J. N., van Santen, S., Linden, D. E. J., Staals, J., van Mook, W. N. K. A., Jansen, J. F. A., van der Horst, I. C. C., van Bussel, B. C. T., & Ariës, M. J. H. (2024). The incidence of neurological complications in mechanically ventilated COVID-19 ICU patients: An observational single-center cohort study in three COVID-19 periods. Clinical Neurology and Neurosurgery, 241, Article 108311. https://doi.org/10.1016/j.clineuro.2024.108311

Overview

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Julie Staals

Professor