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CARIM's Confidential Contact Persons

CARIM's Confidential Contact Persons

27 November 2024

Dr Magdi Nagy (Dept of Biochemistry) and Prof. Peter de Leeuw (Dept of Internal Medicine) have been appointed as CARIM Confidential Contact Persons.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

27 November 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.

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Carim Maastricht
Carim Maastricht

Julie Staals

Professor

Prof.  Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

Julie Staals  has been appointed as professor 'Neurovascular disease' as of 1 April 2024. Julie is neurologist at Maastricht UMC+ and leader of the stroke clinic. Her research aims at unravelling the pathophysiology of cerebral small vessel disease, a common ageing-related disease leading to stroke and dementia, which falls within the research programs of both CARIM and MHeNS. Furthermore she is involved in clinical studies on the very successfull acute endovascular stroke treatment. The inaugural lecture will follow later.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)

 

Julie-staals

Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2016
    • Fransen, P. S. S., Berkhemer, O. A., Lingsma, H. F., Beumer, D., van den Berg, L. A., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2016). Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke A Randomized Clinical Trial. JAMA Neurology, 73(2), 190-196. https://doi.org/10.1001/jamaneurol.2015.3886
  • 2015
    • Staals, J., Booth, T., Morris, Z., Bastin, M. E., Gow, A. J., Corley, J., Redmond, P., Starr, J. M., Deary, I. J., & Wardlaw, J. M. (2015). Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiology of Aging, 36(10), 2806-2811. https://doi.org/10.1016/j.neurobiolaging.2015.06.024
    • Loos, C. M. J., Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 10(9), Article e0137323. https://doi.org/10.1371/journal.pone.0137323
    • Parry-Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre-Ponchelle, N., Lee-Archer, M., Horstmann, S., Wilson, D., Pomero, F., Masotti, L., Lerpiniere, C., Godoy, D. A., Cohen, A. S., Houben, R., Al-Shahi Salman, R., ... Meretoja, A. (2015). Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology, 78(1), 54-62. https://doi.org/10.1002/ana.24416
    • Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Ambulatory Arterial Stiffness Index Is Not Associated With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Lacunar Stroke Patients. Journal of Clinical Hypertension, 17(5), 352-356. https://doi.org/10.1111/jch.12504
    • Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2015). A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke. New England Journal of Medicine, 372(1), 11-20. https://doi.org/10.1056/NEJMoa1411587
  • 2014
    • Staals, J., Makin, S. D. J., Doubal, F. N., Dennis, M. S., & Wardlaw, J. M. (2014). Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology, 83(14), 1228-1234. https://doi.org/10.1212/WNL.0000000000000837
    • Uiterwijk, R., Huijts, M., Staals, J., Duits, A., Gronenschild, E., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds. Hypertension, 64(3), 653-657. https://doi.org/10.1161/HYPERTENSIONAHA.114.03621
    • van Dooren, M., Staals, J., de Leeuw, P. W., Kroon, A. A., Henskens, L. H., & van Oostenbrugge, R. J. (2014). Progression of Brain Microbleeds in Essential Hypertensive Patients: A 2-Year Follow-up Study. American Journal of Hypertension, 27(8), 1045-1051. https://doi.org/10.1093/ajh/hpu032
    • Schols, A. M. R., Schreuder, F. H. B. M., van Raak, E. P. M., Schreuder, T. H. C. M. L., Rooyer, F. A., van Oostenbrugge, R. J., & Staals, J. (2014). Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands. Stroke, 45(1), 268-270. https://doi.org/10.1161/STROKEAHA.113.003003
    • Huijts, M., Duits, A., Staals, J., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease. Current Neurovascular Research, 11(2), 136-141. https://doi.org/10.2174/1567202611666140310102248
  • 2013
    • Huijts, M., Duits, A., van Oostenbrugge, R. J., Kroon, A. A., de Leeuw, P. W., & Staals, J. (2013). Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients. Frontiers in Aging Neuroscience, 5(NOV), Article 72. https://doi.org/10.3389/fnagi.2013.00072
    • Klarenbeek, P., van Oostenbrugge, R. J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Ambulatory Blood Pressure in Patients With Lacunar Stroke Association With Total MRI Burden of Cerebral Small Vessel Disease. Stroke, 44(11), 2995-2999. https://doi.org/10.1161/STROKEAHA.113.002545
    • van Overbeek, E. C., Staals, J., & van Oostenbrugge, R. J. (2013). Vitamin B12 and Progression of White Matter Lesions. A 2-Year Follow-Up Study in First-Ever Lacunar Stroke Patients. PLOS ONE, 8(10). https://doi.org/10.1371/journal.pone.0078100
    • Klarenbeek, P., van Oostenbrugge, R. J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Higher Ambulatory Blood Pressure Relates to New Cerebral Microbleeds 2-Year Follow-Up Study in Lacunar Stroke Patients. Stroke, 44(4), 978-983. https://doi.org/10.1161/STROKEAHA.111.676619
    • Klarenbeek, P., van Oostenbrugge, R. J., Lodder, J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Higher ambulatory blood pressure relates to enlarged Virchow-Robin spaces in first-ever lacunar stroke patients. Journal of Neurology, 260(1), 115-121. https://doi.org/10.1007/s00415-012-6598-z
    • Martens, R. J. H., Vink, H., van Oostenbrugge, R. J., & Staals, J. (2013). Sublingual Microvascular Glycocalyx Dimensions in Lacunar Stroke Patients. Cerebrovascular Diseases, 35(5), 451-454. https://doi.org/10.1159/000348854
  • 2012
    • Loos, C. M. J., Staals, J., Wardlaw, J. M., & van Oostenbrugge, R. J. (2012). Cavitation of Deep Lacunar Infarcts in Patients With First-Ever Lacunar Stroke A 2-Year Follow-Up Study With MR. Stroke, 43(8), 2245-U450. https://doi.org/10.1161/STROKEAHA.112.660076
    • Rouhl, R. P. W., Damoiseaux, J. G. M. C., Lodder, J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Tervaert, J. W. C., & van Oostenbrugge, R. J. (2012). Vascular inflammation in cerebral small vessel disease. Neurobiology of Aging, 33(8), 1800-1806. https://doi.org/10.1016/j.neurobiolaging.2011.04.008
    • Knottnerus, I. L. H., Winckers, K., ten Cate, H., Hackeng, T. M., Lodder, J., Rouhl, R. P. W., Staals, J., Govers-Riemslag, J. W. P., Bekers, O., & van Oostenbrugge, R. J. (2012). Levels of heparin-releasable TFPI are increased in first-ever lacunar stroke patients. Neurology, 78(7), 493-498. https://doi.org/10.1212/WNL.0b013e318246d6b7
    • Huijts, M., Duits, A., Staals, J., & van Oostenbrugge, R. J. (2012). Association of Vitamin B12 Deficiency with Fatigue and Depression after Lacunar Stroke. PLOS ONE, 7(1), Article e30519. https://doi.org/10.1371/journal.pone.0030519
    • Loos, C. M. J., van Oostenbrugge, R. J., & Staals, J. (2012). The Appearance of a New White Matter Lesion Adjacent to the Old Infarct in First-Ever Lacunar Stroke Patients: A Two-Year Follow-Up Study with MRI. Cerebrovascular Diseases, 34(5-6), 443-445. https://doi.org/10.1159/000344003
  • 2010
    • Rouhl, R. P. W., van Oostenbrugge, R. J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Lodder, J., Tervaert, J. W. C., & Damoiseaux, J. G. M. C. (2010). Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease. Stroke, 41(11), 2687-2689. https://doi.org/10.1161/STROKEAHA.110.592725
    • Knottnerus, I. L. H., Govers-Riemslag, J. W. P., Hamulyak, K., Rouhl, R. P. W., Staals, J., Spronk, H. M. H., van Oerle, R., van Raak, E. P. M., Lodder, J., ten Cate, H., & van Oostenbrugge, R. J. (2010). Endothelial Activation in Lacunar Stroke Subtypes. Stroke, 41(8), 1617-1622. https://doi.org/10.1161/STROKEAHA.109.576223
    • Staals, J., Henskens, L. H. G., Delanghe, J. R., van Oostenbrugge, R. J., Kessels, A. G., Kroon, A. A., de Leeuw, P. W., & Lodder, J. (2010). Haptoglobin Phenotype Correlates with the Extent of Cerebral Deep White Matter Lesions in Hypertensive Patients. Current Neurovascular Research, 7(1), 1-5. https://doi.org/10.2174/156720210790820163
    • Zhang, C. E., van Raak, E. P. M., Rouhl, R. P. W., Lodder, J., Staals, J., Knottnerus, I. L. H., & van Oostenbrugge, R. J. (2010). Metabolic Syndrome Relates to Lacunar Stroke without White Matter Lesions: A Study in First-Ever Lacunar Stroke Patients. Cerebrovascular Diseases, 29(5), 503-507. https://doi.org/10.1159/000297967
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