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CARIM's Confidential Contact Persons

CARIM's Confidential Contact Persons

27 November 2024

Dr Magdi Nagy (Dept of Biochemistry) and Prof. Peter de Leeuw (Dept of Internal Medicine) have been appointed as CARIM Confidential Contact Persons.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

27 November 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.

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Carim Maastricht
Carim Maastricht

Marc van Zandvoort

Professor

Prof. Marc A.M.J. van Zandvoort achieved his PhD degree in Biophysics at Utrecht University (1994) and worked as a postdoc at Universitá di Bologna and LENS institute, Florence (Italy). He returned to Utrecht University as a postdoc in 1996. In 1998, he moved to Maastricht University first as postdoc, from 2000 as assistant professor Biophysics. In 2007, he became associate professor at the department of Biomedical Engineering. In 2012, he moved to the department of Molecular Cell Biology. Currently, he is interim head of that department. In 2017 he obtained the chair 'Advanced Optical Microscopy' in Maastricht.

In 2009, he became professor Biophysics of Microscopy (part-time) at the Universitätsklinikum Aachen (Germany) and scientific leader of the Two-photon core-facility in Aachen.

He is board member of the conference series Focus on Microscopy, board member of the Dutch Society of Microscopy, and board member of the NL-BioImaging-AM initiative. He also is leader of the EuroBioImaging Node Maastricht.

His research currently zooms on the application of advanced optical microscopy (multi-photon, high-resolution 3D-STED microscopy, spectral microscopy) to biomedical cardiovascular and oncological questions. As an example, his group recently developed a method to measure mouse carotid plaque microvessel functionality using in vivo multi-photon microscopy. He has also done a variety of studies on bimodal (e.g., optical-MRI, optical-US) imaging. In combination with the techniques used, a variety of systems can be studied, ranging from artificial systems, via cells in culture (e.g., lamin substructure, mitochondrial network and substructure), to whole tissues, organs, and animals.

He has tutored both scientists with background in physics and biomedical research. He is an experienced teacher for a wide range of students (medicine, biomedical engineering, science students) and in a variety of roles (mentor, tutor, internship). His research group currently encompasses technicians, PhD students and postdocs in Maastricht and Aachen. Finally, he has been organising the TripleM PhD/Postdoc course and conference series in Maastricht.

Marc-van-zandvoort_5d5f9d20184f1

Department of Molecular Cell Biology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31 (0)43 388 13 61

  • 2024
    • Al Enezy-Ulbrich, M. A., Belthle, T., Malyaran, H., Kucikas, V., Kuettner, H., de Lange, R. D., van Zandvoort, M., Neuss, S., & Pich, A. (2024). Fibrin Hydrogels Reinforced by Reactive Microgels for Stimulus-Triggered Drug Administration. Small, 20(42), Article 2309912. https://doi.org/10.1002/smll.202309912
    • Rademakers, T., Manca, M., Jin, H., Orban, T., Perisic, L. M., Frissen, H. J. M., Rühle, F., Hautvast, P., van Rijssel, J., van Kuijk, K., Mees, B. M. E., Peutz-Kootstra, C. J., Heeneman, S., Daemen, M. J. A. P., Pasterkamp, G., Stoll, M., van Zandvoort, M. A. M. J., Hedin, U., Dequiedt, F., ... Biessen, E. A. L. (2024). Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype. Angiogenesis, 27(3), 461-474. https://doi.org/10.1007/s10456-024-09921-z
    • Ahmadian, S., Lindsey, P. J., Smeets, H. J. M., van Tienen, F. H. J., & van Zandvoort, M. A. M. J. (2024). Spinning Disk Confocal Microscopy for Optimized and Quantified Live Imaging of 3D Mitochondrial Network. International Journal of Molecular Sciences, 25(9), Article 4819. https://doi.org/10.3390/ijms25094819
    • You, W., Knoops, K., Boesten, I., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2024). A time window for rescuing dying retinal ganglion cells. Cell Communication and Signaling, 22(1), Article 88. https://doi.org/10.1186/s12964-023-01427-3
    • Werner, M. P., Kucikas, V., Voß, K., Abel, D., Jockenhoevel, S., van Zandvoort, M. A. M. J., & Schmitz-Rode, T. (2024). Multiphoton imaging of maturation in tissue engineering. Tissue Engineering, 30(1), 38-48. https://doi.org/10.1089/ten.TEC.2023.0141
  • 2023
    • van Lanen, R. H. G. J., Haeren, R. H. L., Staals, J., Dings, J. T. A., Schijns, O. E. M. G., Hoogland, G., van Kuijk, S. M. J., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Vink, H., Rijkers, K., & ACE Epilepsy Surgery Group (2023). Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy. Journal of Cerebral Blood Flow and Metabolism, 43(10), 1737-1751. https://doi.org/10.1177/0271678X231179413
    • Jung, S. A., Malyaran, H., Demco, D. E., Manukanc, A., Häser, L. S., Kucikas, V., van Zandvoort, M., Neuss, S., & Pich, A. (2023). Fibrin-Dextran Hydrogels with Tunable Porosity and Mechanical Properties. Biomacromolecules, 24(9), 3972-3984. https://doi.org/10.1021/acs.biomac.3c00269
    • You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2023). Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release. Scientific Reports, 13(1), Article 11045. https://doi.org/10.1038/s41598-023-38210-w
    • De Lorenzi, F., Rizzo, L. Y., Daware, R., Motta, A., Baues, M., Bartneck, M., Vogt, M., van Zandvoort, M., Kaps, L., Hu, Q., Thewissen, M., Casettari, L., Rijcken, C. J. F., Kiessling, F., Sofias, A. M., & Lammers, T. (2023). Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles. Drug Delivery and Translational Research, 13(5), 1195-1211. https://doi.org/10.1007/s13346-022-01204-8
    • Kylies, D., Zimmermann, M., Haas, F., Schwerk, M., Kuehl, M., Brehler, M., Czogalla, J., Hernandez, L. C., Konczalla, L., Okabayashi, Y., Menzel, J., Edenhofer, I., Mezher, S., Aypek, H., Dumoulin, B., Wu, H., Hofmann, S., Kretz, O., Wanner, N., ... Puelles, V. G. (2023). Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens. Nature Nanotechnology, 18(4), 336-342. https://doi.org/10.1038/s41565-023-01328-z
    • Hermans, S., Pilon, J., Eschweiler, D., Stegmaier, J., Severens-Rijvers, C. A. H., Al-Nasiry, S., van Zandvoort, M., & Kapsokalyvas, D. (2023). Definition and Quantification of Three-Dimensional Imaging Targets to Phenotype Pre-Eclampsia Subtypes: An Exploratory Study. International Journal of Molecular Sciences, 24(4), Article 3240. https://doi.org/10.3390/ijms24043240
    • Kucikas, V., Werner, M. P., Schmitz-Rode, T., Louradour, F., & van Zandvoort, M. A. M. J. (2023). Two-Photon Endoscopy: State of the Art and Perspectives. Molecular Imaging and Biology, 25(1), 3-17. https://doi.org/10.1007/s11307-021-01665-2
  • 2022
    • Voß, K., Werner, M. P., Gesenhues, J., Kučikas, V., van Zandvoort, M., Jockenhoevel, S., Schmitz-Rode, T., & Abel, D. (2022). Towards technically controlled bioreactor maturation of tissue-engineered heart valves. Biomedizinische Technik, 67(6), 461-470. https://doi.org/10.1515/bmt-2021-0379
    • Momoh, J., Kapsokalyvas, D., Vogt, M., Hak, S., Kiessling, F., van Zandvoort, M., Lammers, T., & Marios Sofias, A. (2022). Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes. Advanced Drug Delivery Reviews, 189, Article 114528. https://doi.org/10.1016/j.addr.2022.114528
    • Goossens, P., Lu, C., Cao, J., Gijbels, M. J., Karel, J. M. H., Wijnands, E., Claes, B. S. R., Fazzi, G. E., Hendriks, T. F. E., Wouters, K., Smirnov, E., van Zandvoort, M. J. M., Balluff, B., Cuypers, E., Donners, M. M. P. C., Heeren, R. M. A., & Biessen, E. A. L. (2022). Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context. Cell Metabolism, 34(8), 1214-1225.e6. https://doi.org/10.1016/j.cmet.2022.06.012
    • Neupane, B., Pradhan, K., Ortega-Ramirez, A. M., Aidery, P., Kucikas, V., Marks, M., van Zandvoort, M. A. M. J., Klingel, K., Witte, K. K., Grunder, S., Marx, N., & Gramlich, M. (2022). Personalized Medicine Approach in a DCM Patient with LMNA Mutation Reveals Dysregulation of mTOR Signaling. Journal of Personalized Medicine, 12(7), Article 1149. https://doi.org/10.3390/jpm12071149
    • Stiekema, M., Houben, F., Verheyen, F., Borgers, M., Menzel, J., Meschkat, M., van Zandvoort, M. A. M. J., Ramaekers, F. C. S., & Broers, J. L. V. (2022). The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay. Frontiers in Cell and Developmental Biology, 10, Article 914286. https://doi.org/10.3389/fcell.2022.914286
    • You, W., Berendschot, T. T. J. M., Knoops, K., van Zandvoort, M. A. M. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2022). Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells. International journal of molecular sciences, 23(5), Article 2650. https://doi.org/10.3390/ijms23052650
  • 2021
    • Stiekema, M., Ramaekers, F. C. S., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Veltrop, R. J. A., & Broers, J. L. V. (2021). Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures. International Journal of Molecular Sciences, 22(19), Article 10194. https://doi.org/10.3390/ijms221910194
    • van Lanen, R. H. G. J., Melchers, S., Hoogland, G., Schijns, O. E. M. G., van Zandvoort, M. A. J., Haeren, R. H. L., & Rijkers, K. (2021). Microvascular changes associated with epilepsy: A narrative review. Journal of Cerebral Blood Flow and Metabolism, 41(10), 2492-2509. https://doi.org/10.1177/0271678X211010388
    • Houben, T., Yadati, T., De Kruijf, R., Gijbels, M. J. J., Luiken, J. J. F. P., Van Zandvoort, M., Kapsokalyvas, D., Lutjohann, D., Westerterp, M., Plat, J., Leake, D., & Shiri-Sverdlov, R. (2021). Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment. Frontiers in Immunology, 12, Article 716357. https://doi.org/10.3389/fimmu.2021.716357
    • Dickhout, A., Kaczor, D. M., Heinzmann, A. C. A., Brouns, S. L. N., Heemskerk, J. W. M., van Zandvoort, M. A. M. J., & Koenen, R. R. (2021). Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. International journal of molecular sciences, 22(14), Article 7332. https://doi.org/10.3390/ijms22147332
    • Kapsokalyvas, D., Rosas, R., Janssen, R. W. A., Vanoevelen, J. M., Nabben, M., Strauch, M., Merhof, D., & van Zandvoort, M. A. M. J. (2021). Multiview deconvolution approximation multiphoton microscopy of tissues and zebrafish larvae. Scientific Reports, 11(1), Article 10160. https://doi.org/10.1038/s41598-021-89566-w
    • Kerselidou, D., Dohai, B. S., Nelson, D. R., Daakour, S., De Cock, N., Hassoun, Z. A. O., Kim, D.-K., Olivet, J., El Assal, D. C., Jaiswal, A., Alzahmi, A., Saha, D., Pain, C., Matthijssens, F., Lemaitre, P., Herfs, M., Chapuis, J., Ghesquiere, B., Vertommen, D., ... Twizere, J.-C. (2021). Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Science advances, 7(19), Article 8349. https://doi.org/10.1126/sciadv.abe8349
    • Khan, L., van Lanen, R., Hoogland, G., Schijns, O., Rijkers, K., Kapsokalyvas, D., van Zandvoort, M., & Haeren, R. (2021). Two-Photon Imaging to Unravel the Pathomechanisms Associated with Epileptic Seizures: A Review. Applied sciences-Basel, 11(5), Article 2404. https://doi.org/10.3390/app11052404
    • Hakvoort, K., Otto, L., Haeren, R., Hoogland, G., Schijns, O., Vink, H., Klein, D., van Zandvoort, M., & Rijkers, K. (2021). Shedding light on human cerebral lipofuscin: An explorative study on identification and quantification. Journal of Comparative Neurology, 529(3), 605-615. https://doi.org/10.1002/cne.24971
  • 2020
    • Merckx, G., Tay, H., Lo Monaco, M., van Zandvoort, M., De Spiegelaere, W., Lambrichts, I., & Bronckaers, A. (2020). Chorioallantoic Membrane Assay as Model for Angiogenesis in Tissue Engineering: Focus on Stem Cells. Tissue Engineering - Part B: Reviews, 26(6), 519-539. https://doi.org/10.1089/ten.teb.2020.0048
    • Bartmann, L., Schumacher, D., von Stillfried, S., Sternkopf, M., Alampour-Rajabi, S., van Zandvoort, M. A. M. J., Kiessling, F., & Wu, Z. J. (2020). Corrigendum: Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics. Frontiers in Pharmacology, 11, Article 617329. https://doi.org/10.3389/fphar.2020.617329
    • Stiekema, M., van Zandvoort, M. A. M. J., Ramaekers, F. C. S., & Broers, J. L. (2020). Structural and Mechanical Aberrations of the Nuclear Lamina in Disease. Cells, 9(8), 1-22. Article 1884. https://doi.org/10.3390/cells9081884
    • Baues, M., Klinkhammer, B. M., Ehling, J., Gremse, F., van Zandvoort, M. A. M. J., Reutelingsperger, C. P. M., Daniel, C., Amann, K., Babickova, J., Kiessling, F., Floege, J., Lammers, T., & Boor, P. (2020). A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International, 97(3), 609-614. https://doi.org/10.1016/j.kint.2019.08.029
    • Kapsokalyvas, D., Loos, J., Boogers, I. A. L. A., Appeldoorn, M. M., Kabel, M. A., & Van Zandvoort, M. (2020). Quantification of morphochemical changes during in situ enzymatic hydrolysis of individual biomass particles based on autofluorescence imaging. Biopolymers, 111(3), Article e23347. https://doi.org/10.1002/bip.23347
    • Gomez, I., Ward, B., Souilhol, C., Recarti, C., Ariaans, M., Johnston, J., Burnett, A., Mahmoud, M., Le Anh Luong, West, L., Long, M., Parry, S., Woods, R., Hulston, C., Benedikter, B., Niespolo, C., Bazaz, R., Francis, S., Kiss-Toth, E., ... Ridger, V. (2020). Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1), Article 214. https://doi.org/10.1038/s41467-019-14043-y
    • Kapsokalyvas, D., & van Zandvoort, M. A. M. J. (2020). Molecular Imaging in Oncology: Advanced Microscopy Techniques. Recent Results in Cancer Research, 216, 533-561. https://doi.org/10.1007/978-3-030-42618-7_16
  • 2019
    • Vig, S., Buitinga, M., Rondas, D., Crevecoeur, I., van Zandvoort, M., Waelkens, E., Eizirik, D. L., Gysemans, C., Baatsen, P., Mathieu, C., & Overbergh, L. (2019). Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells. Cell Death & Disease, 10(4), 1-13. Article 309. https://doi.org/10.1038/s41419-019-1518-0
    • Bartmann, L., Schumacher, D., von Stillfried, S., Sternkopf, M., Alampour-Rajabi, S., van Zandvoort, M. A. M. J., Kiessling, F., & Wu, Z. (2019). Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics. Frontiers in Pharmacology, 10(FEB), 1-12. Article 79. https://doi.org/10.3389/fphar.2019.00079
    • van Zandvoort, M. (2019). Guy Cox, Fundamentals of Fluorescence Imaging, 2019, Jenny Stanford Publishing; Singapore.Micron, 124, Article 102707. https://doi.org/10.1016/j.micron.2019.102707
  • 2018
    • Gemmink, A., Daemen, S., Kuijpers, H. J. H., Schaart, G., Duimel, H., Lopez-Iglesias, C., van Zandvoort, M. A. M. J., Knoops, K., & Hesselink, M. K. C. (2018). Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1863(11), 1423-1432. https://doi.org/10.1016/j.bbalip.2018.08.016
    • Kapsokalyvas, D., Wilbers, A., Boogers, I. A. L. A., Appeldoorn, M. M., Kabel, M. A., Loos, J., & Van Zandvoort, M. A. M. J. (2018). Biomass Pretreatment and Enzymatic Hydrolysis Dynamics Analysis Based on Particle Size Imaging. Microscopy and Microanalysis, 24(5), 517-525. https://doi.org/10.1017/S1431927618015143
    • Sutanto, H., van Sloun, B., Schönleitner, P., van Zandvoort, M. A. M. J., Antoons, G., & Heijman, J. (2018). The Subcellular Distribution of Ryanodine Receptors and L-Type Ca2+ Channels Modulates Ca2+-Transient Properties and Spontaneous Ca2+-Release Events in Atrial Cardiomyocytes. Frontiers in physiology, 9(AUG), Article 1108. https://doi.org/10.3389/fphys.2018.01108
    • Haeren, R. H. L., Rijkers, K., Schijns, O. E. M. G., Dings, J., Hoogland, G., van Zandvoort, M. A. M. J., Vink, H., & van Overbeeke, J. J. (2018). In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report. Journal of Neuroscience Methods, 303, 114-125. https://doi.org/10.1016/j.jneumeth.2018.03.009
    • Bisha, M., Dao, T.-V., Gholamreza-Fahimi, E., Vogt, M., van Zandvoort, M., Weber, S., Bas, M., Khosravani, F., Kojda, G., & Suvorava, T. (2018). The role of bradykinin receptor type 2 in spontaneous extravasation in mice skin: implications for non-allergic angio-oedema. British Journal of Pharmacology, 175(10), 1607-1620. https://doi.org/10.1111/bph.14166
    • Curaj, A., Wu, Z., Rix, A., Gresch, O., Sternkopf, M., Alampour-Rajabi, S., Lammers, T., van Zandvoort, M., Weber, C., Koenen, R. R., Liehn, E. A., & Kiessling, F. (2018). Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation. Arteriosclerosis Thrombosis and Vascular Biology, 38(1), 40-48. https://doi.org/10.1161/ATVBAHA.117.309503
  • 2017
    • Kapsokalyvas, D., van Hoof, M., Wigren, S., Chimhanda, T., Kuijpers, H. J., Ramaekers, F. C. S., Stokroos, R. J., & van Zandvoort, M. A. M. J. (2017). Investigating the race for the surface and skin integration in clinically retrieved abutments with two-photon microscopy. Colloids and Surfaces B-Biointerfaces, 159, 97-107. https://doi.org/10.1016/j.colsurfb.2017.07.072
    • Wu, Z., Rademakers, T., Kiessling, F., Vogt, M., Westein, E., Weber, C., Megens, R. T. A., & van Zandvoort, M. (2017). Multi-photon microscopy in cardiovascular research. Methods, 130, 79-89. https://doi.org/10.1016/j.ymeth.2017.04.013
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2017). Computer-assisted three-dimensional tracking of sensory innervation in the murine bladder mucosa with two-photon microscopy. Journal of Chemical Neuroanatomy, 85, 43-49. https://doi.org/10.1016/j.jchemneu.2017.06.006
    • Zafarnia, S., Bzyl-Ibach, J., Spivak, I., Li, Y., Koletnik, S., Doleschel, D., Rix, A., Pochon, S., Tardy, I., Koyadan, S., van Zandvoort, M., Palmowski, M., Kiessling, F., & Lederle, W. (2017). Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response. Neoplasia (Online), 19(11), 896-907. https://doi.org/10.1016/j.neo.2017.08.009
    • Koczera, P., Appold, L., Shi, Y., Liu, M., Dasgupta, A., Pathak, V., Ojha, T., Fokong, S., Wu, Z., van Zandvoort, M., Iranzo, O., Kuehne, A. J. C., Pich, A., Kiessling, F., & Lammers, T. (2017). PBCA-based polymeric microbubbles for molecular imaging and drug delivery. Journal of Controlled Release, 259, 128-135. https://doi.org/10.1016/j.jconrel.2017.03.006
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