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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Steven Meex

Clinical Chemist

Dr Steven Meex is a clinical chemist and head of the unit general clinical chemistry and hematology of the Central Diagnostic Laboratory of Maastrcith UMC+. He graduated in 2002 with specialisation in both molecular biology and epidemiology at Maastricht University. During his PhD at the Department of Internal Medicine in Maastricht, he worked on the cardiovascular genetics including type 2 diabetes and hyperlipidemia. Subsequently, he worked as acardiovascular research fellow at San Diego State University (2006) and at New York University (2008-2009).

His current research is focussed on cardiac markers,combining epidemiology, cell biology, analytical chemistry, and patient studies to improve the diagnosis and treatment of cardiovascular diseases.

Steven-meex

Central Diagnostic Laboratory
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
Room number: 5.E2.002
T: +31(0)43 387 47 09

  • 2017
    • Hilderink, J. M., Rennenberg, R. J. M. W., Vanmolkot, F. H. M., Bekers, O., Koopmans, R. P., & Meex, S. J. R. (2017). Labtracker plus , a medical smartphone app for the interpretation of consecutive laboratory results: an external validation study. BMJ Open, 7(9), Article 015854. https://doi.org/10.1136/bmjopen-2017-015854
    • Kimenai, D. M., Martens, R. J. H., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Schaper, N. C., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Sep, S. J. S., van Suijlen, J. D. E., Kroon, A. A., Bekers, O., van Dieijen-Visser, M. P., Henry, R. M. A., & Meex, S. J. R. (2017). Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study. Scientific Reports, 7(1), Article 6610. https://doi.org/10.1038/s41598-017-06978-3
    • van der Linden, N., Streng, A. S., Bekers, O., Wodzig, W. K. W. H., Meex, S. J. R., & de Boer, D. (2017). Large Variation in Measured Cardiac Troponin T Concentrations after Standard Addition in Serum or Plasma of Different Individuals. Clinical Chemistry, 63(7), 1300-1302. https://doi.org/10.1373/clinchem.2017.272435
    • Hilderink, J. M., Klinkenberg, L. J. J., Aakre, K. M., de Wit, N. C. J., Henskens, Y. M. C., van der Linden, N., Bekers, O., Rennenberg, R. J. M. W., Koopmans, R. P., & Meex, S. J. R. (2017). Within-day biological variation and hour-to-hour reference change values for hematological parameters. Clinical Chemistry and Laboratory Medicine, 55(7), 1013-1024. https://doi.org/10.1515/cclm-2016-0716
    • Van Der Linden, N., Streng, A. S., Wodzig, W. K. W. H., Bekers, O., & Meex, S. J. R. (2017). Better, higher, lower, faster: increasingly rapid clinical decision making using high-sensitivity cardiac troponin assays. Journal of Laboratory and Precision Medicine, 2, Article 14. https://doi.org/10.21037/jlpm.2017.04.03
    • Martens, R. J. H., Kimenai, D. M., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Bekers, O., Dagnelie, P. C., van der Kallen, C. J. H., Kroon, A. A., Leunissen, K. M. L., van der Sande, F. M., Schaper, N. C., Sep, S. J. S., Schram, M. T., van Suijlen, J. D., van Dieijen-Visser, M. P., Meex, S. J. R., & Henry, R. M. A. (2017). Estimated Glomerular Filtration Rate and Albuminuria Are Associated with Biomarkers of Cardiac Injury in a Population-Based Cohort Study: The Maastricht Study. Clinical Chemistry, 63(4), 887-897. https://doi.org/10.1373/clinchem.2016.266031
  • 2016
    • Peeters, F. E. C. M., Van der Linden, N., Thomassen, A. L. L., Crijns, H. J. G. M., Meex, S. J. R., & Kietselaer, B. L. J. H. (2016). Clinical and echocardiographic determinants in bicuspid aortic dilatation Results from a longitudinal observational study. Medicine, 95(52), Article e5699. https://doi.org/10.1097/MD.0000000000005699
    • Klinkenberg, L. J. J., Wildi, K., van der Linden, N., Kouw, I. W. K., Niens, M., Twerenbold, R., Gimenez, M. R., Puelacher, C., Neuhaus, J. D., Hillinger, P., Nestelberger, T., Boeddinghaus, J., Grimm, K., Sabti, Z., Bons, J. A. P., van Suijlen, J. D. E., Tan, F. E. S., ten Kate, J., Bekers, O., ... Meex, S. J. R. (2016). Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction. Clinical Chemistry, 62(12), 1602-1611. https://doi.org/10.1373/clinchem.2016.257485
    • van der Linden, N., Klinkenberg, L. J. J., Bekers, O., van Loon, L. J. C., van Dieijen-Visser, M. P., Zeegers, M. P., & Meex, S. J. R. (2016). Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population A meta-analysis. Medicine, 95(52), Article e5703. https://doi.org/10.1097/MD.0000000000005703
    • van der Linden, N., Cornelis, T., Klinkenberg, L. J. J., Kimenai, D. M., Hilderink, J. M., Litjens, E. J. R., Kooman, J. P., Bekers, O., van Dieijen-Visser, M. P., & Meex, S. J. R. (2016). Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction. International Journal of Cardiology, 221, 287-288. https://doi.org/10.1016/j.ijcard.2016.06.268
    • Marsch, E., Demandt, J. A. F., Theelen, T. L., Tullemans, B. M. E., Wouters, K., Boon, M. R., van Dijk, T. H., Gijbels, M. J., Dubois, L. J., Meex, S. J. R., Mazzone, M., Hung, G., Fisher, E. A., Biessen, E. A. L., Daemen, M. J. A. P., Rensen, P. C. N., Carmeliet, P., Groen, A. K., & Sluimer, J. C. (2016). Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. European Heart Journal, 37(39), 2993-2997. https://doi.org/10.1093/eurheartj/ehw156
    • Klinkenberg, L. J. J., Luyten, P., van der Linden, N., Urgel, K., Snijders, D. P. C., Knackstedt, C., Dennert, R., Kietselaer, B. L. J. H., Mingels, A., Cardinaels, E. P. M., Peeters, F. E. C. M., van Suijlen, J. D. E., ten Kate, J., Marsch, E., Theelen, T. L., Sluimer, J. C., Wouters, K., Bekers, O., Bekkers, B., ... Meex, S. J. R. (2016). Cardiac Troponin T and I Release After a 30-km Run. American Journal of Cardiology, 118(2), 281-287. https://doi.org/10.1016/j.amjcard.2016.04.030
    • Muris, A.-H., Smolders, J., Rolf, L., Klinkenberg, L. J. J., van der Linden, N., Meex, S., Damoiseaux, J., & Hupperts, R. (2016). Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up. PLOS ONE, 11(6), Article e0156122. https://doi.org/10.1371/journal.pone.0156122
    • Huskens, D., Roest, M., Remijn, J. A., Konings, J., Kremers, R. M. W., Bloemen, S., Schurgers, E., Selmeczi, A., Kelchtermans, H., van Meel, R., Meex, S. J., Kleinegris, M.-C., de Groot, P. G., Urbanus, R. T., Ninivaggi, M., & de Laat, B. (2016). Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men. Thrombosis and Haemostasis, 115(6), 1109-1119. https://doi.org/10.1160/TH15-10-0821
    • Kimenai, D. M., Henry, R. M. A., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Stehouwer, C. D. A., van Suijlen, J. D. E., Niens, M., Bekers, O., Sep, S. J. S., Schaper, N. C., van Dieijen-Visser, M. P., & Meex, S. J. R. (2016). Direct comparison of clinical decision limits for cardiac troponin T and I. Heart, 102(8), 610-616. https://doi.org/10.1136/heartjnl-2015-308917
    • Hilderink, J. M., Koopmans, R. P., Rennenberg, R. J. M. W., Van Dieijen-Visser, M. P., & Meex, S. J. R. (2016). Echte verandering of natuurlijke schommeling?Nederlands Tijdschrift voor Geneeskunde, 160(32), Article D132A.
    • Klinkenberg, L. J. J., Bekers, O., & Meex, S. J. R. (2016). Update: Europese NSTEMI richtlijn 2015. Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 41(1), 49-53.
  • 2015
    • van der Linden, N., Klinkenberg, L. J., Leenders, M., Tieland, M., Verdijk, L., Niens, M., van Suijlen, J. D. E., de Groot, L. C., Bekers, O., van Loon, L. J., van Dieijen-Visser, M. P., & Meex, S. J. R. (2015). The effect of exercise training on the course of cardiac troponin T and I levels: three independent training studies. Scientific Reports, 5, Article 18320. https://doi.org/10.1038/srep18320
    • Hilderink, J. M., Koopmans, R., Rennenberg, R., van Dieijen-Visser, M. P., & Meex, S. J. R. (2015). Calculating the probability of change between two consecutive laboratory test results. BMJ, 351, Article h5552.
  • 2014
    • van der Linden, N., Klinkenberg, L. J. J., Meex, S. J. R., Beckers, E. A. M., de Wit, N. C. J., & Prinzen, L. (2014). Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation. European Journal of Haematology, 93(2), 150-156. https://doi.org/10.1111/ejh.12319
    • Streng, A. S., Jacobs, L. H. J., Schwenk, R. W., Cardinaels, E. P. M., Meex, S. J. R., Glatz, J. F. C., Wodzig, W. K. W. H., & van Dieijen-Visser, M. P. (2014). Cardiac troponin in ischemic cardiomyocytes: Intracellular decrease before onset of cell death. Experimental and Molecular Pathology, 96(3), 339-345. https://doi.org/10.1016/j.yexmp.2014.02.012
    • Klinkenberg, L. J. J., van Dijk, J. W., Tan, F. E. S., van Loon, L. J. C., van Dieijen-Visser, M. P., & Meex, S. J. R. (2014). Circulating Cardiac Troponin T Exhibits a Diurnal Rhythm. Journal of the American College of Cardiology, 63(17), 1788-1795. https://doi.org/10.1016/j.jacc.2014.01.040
    • Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., ... Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023
  • 2012
    • Klinkenberg, L. J., Res, P. T., van Loon, L. J. C., van Dieijen-Visser, M. P., & Meex, S. J. R. (2012). Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk?International Journal of Cardiology, 158(1), 129-131. https://doi.org/10.1016/j.ijcard.2012.04.050
    • Cardinaels, E. P., Mingels, A. M., Jacobs, L. H., Meex, S. J., Bekers, O., & van Dieijen-Visser, M. P. (2012). A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: The challenges that lie ahead. Clinical Chemistry and Laboratory Medicine, 50(5), 791-806. https://doi.org/10.1515/cclm-2011-0895
    • van Dieijen-Visser, M. P., Mingels, A. M., Jacobs, L. H., Cardinaels, E. P., Wodzig, K. W. H., Bekers, O., Klinkenberg, L. J., & Meex, S. J. R. (2012). Troponin, the best there is!Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 37, 15-18.
  • 2011
    • Meex, S. J. R., Andreo, U., Sparks, J. D., & Fisher, E. A. (2011). Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?Journal of Lipid Research, 52(1), 152-158. https://doi.org/10.1194/jlr.D008888
  • 2008
    • Meex, S. J., van Vliet-Ostaptchouk, J. V., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schalkwijk, C. G., Feskens, E. J. M., Blaak, E. E., Wijmenga, C., Hofker, M. H., Stehouwer, C. D., & de Bruin, T. W. (2008). Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians. Molecular Genetics and Metabolism, 94(3), 352-355. https://doi.org/10.1016/j.ymgme.2008.03.011
  • 2007
    • Meex, S. J., van Greevenbroek, M. M. J., Ayoubi, T. A., Vlietinck, R., van Vliet-Ostaptchouk, J. V., Hofker, M. H., Vermeulen, V. M., Schalkwijk, C. G., Feskens, E. J., Boer, J. M., Stehouwer, C. D., van der Kallen, C. J. H., & de Bruin, T. W. (2007). Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. Journal of Clinical Endocrinology & Metabolism, 92(7), 2720-2725. https://doi.org/10.1210/jc.2006-2280
  • 2005
    • Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
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