Publications
- 2024
- Velt, M. J. H., Crijns, H. J. G. M., van Gelder, I. C., Linz, D., van de Lande, M. E., Ten Cate, H., Spronk, H. M. H., de Melis, M., Rienstra, M., & Mulder, B. A. (2024). Dynamic biomarker profiles in patients with paroxysmal atrial fibrillation: Assessing the differences between sinus rhythm and acute atrial fibrillation episode. International Journal of Cardiology, 417, Article 132526. https://doi.org/10.1016/j.ijcard.2024.132526
- Jooss, N. J., Diender, M. G., Fernandez, D. I., Huang, J., Heubel-Moenen, F. C. J., van der Veer, A., Kuijpers, M. J. E., Poulter, N. S., Henskens, Y. M. C., te Loo, M., & Heemskerk, J. W. M. (2024). Restraining of glycoprotein VI- and integrin a2ß1-dependent thrombus formation by platelet PECAM1. Cellular and Molecular Life Sciences, 81(1), Article 44. https://doi.org/10.1007/s00018-023-05058-2
- Battaglini, D., Kelly, T. L., Griffee, M., Fanning, J., Premraj, L., Whitman, G., Porto, D. B., Arora, R., Thomson, D., Pelosi, P., White, N. M., Bassi, G. L., Suen, J., Fraser, J. F., Robba, C., Cho, S. M., Al-Dabbous, T., Alfoudri, H., Shamsah, M., ... Mariani, S. (2024). Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries. Heart & Lung, 68, 131-144. https://doi.org/10.1016/j.hrtlng.2024.06.015
- Chai, J., Wu, J., Yang, J., Ye, T., Gao, Y., Zeng, B., Xiong, W., Kotsyfakis, M., Dijkgraaf, I., Liu, J., Chen, X., & Xu, X. (2024). Cath-HG improves the survival rates and symptoms in LPS-induced septic mice due to its multifunctional properties. International Immunopharmacology, 143(Pt 1), Article 113332. Advance online publication. https://doi.org/10.1016/j.intimp.2024.113332
- De Caterina, R., Ten Cate, H., & Pengo, V. (2024). Non-vitamin K oral anticoagulants in valvular heart disease before surgery: a tale of bridging vs. no bridging. European Heart Journal. Advance online publication. https://doi.org/10.1093/eurheartj/ehae615
- Ranalli, P., & Ten Cate, H. (2024). Venous Thromboembolism Prophylaxis after hematopoietic cell transplantation: still a challenge for haematologists and haemostasiologists. Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1055/a-2434-5010
- Bunge, J. J. H., Mariani, S., Meuwese, C., van Bussel, B. C. T., Di Mauro, M., Wiedeman, D., Saeed, D., Pozzi, M., Loforte, A., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Buscher, H., Salazar, L., Meyns, B., Herr, D., Matteucci, S., Sponga, S., ... Post-Cardiotomy Extracorporeal Life Support (PELS-1) Investigators (2024). Characteristics and Outcomes of Prolonged Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery: The Post-Cardiotomy Extracorporeal Life Support (PELS-1) Cohort Study. Critical Care Medicine, 52(10), e490-e502. https://doi.org/10.1097/CCM.0000000000006349
- D'Italia, G., Schroen, B., & Cosemans, J. M. E. M. (2024). Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities. Esc heart failure, Article 15090. https://doi.org/10.1002/ehf2.15090
- Lips, N., Singh, A., Weir, D., & Karapinar-Carkit, F. (2024). Comparing the performance of multiple trigger tools in identifying medication-related hospital readmissions. Journal of the American Geriatrics Society, Article 19216. https://doi.org/10.1111/jgs.19216
- Bülow Anderberg, S., Huckriede, J., Hultström, M., Larsson, A., de Vries, F., Lipcsey, M., Nicolaes, G. A. F., & Frithiof, R. (2024). Association of corticosteroid therapy with reduced acute kidney injury and lower NET markers in severe COVID-19: an observational study. Intensive Care Medicine Experimental, 12(1), 85. Article 85. https://doi.org/10.1186/s40635-024-00670-3
- Koenen, R. R. (2024). Carbamylation-A Pathologic Posttranslational Modification Affecting Platelet and Von Willebrand Factor Function during Uremic Kidney Disease. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0044-1791550
- de Jong, M. J., Saadan, H., van der Hooft, B. H. M., Hellenbrand, D. L. S., Brüggemann, R. A. G., Ten Cate, H., van Kuijk, S. M. J., van Geel, R. M. J. M., Henskens, Y. M. C., Winckers, K., & Magdelijns, F. J. H. (2024). Intra-Individual Variability of Direct Oral Anticoagulant Levels in Frail Older Patients upon, during, and after Acute Hospitalization: the DOAC-FRAIL Study. Journal of the American Medical Directors Association, 25(12), Article 105280. Advance online publication. https://doi.org/10.1016/j.jamda.2024.105280
- Hupperetz, R. D., Iding, A. F., van Laanen, J., Brans, R., Notten, P., Tick, L. W., Vleming, L.-J., Jie, A., Planken, N., Wittens, C. H. A., Ten Cate, H., & Ten Cate-Hoek, A. J. (2024). Patency and reflux in relation to post-thrombotic syndrome: a subanalysis of the Ultrasound-Accelerated Catheter-Directed Thrombolysis Versus Anticoagulation for the Prevention of Post-Thrombotic Syndrome trial. Journal of Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1016/j.jtha.2024.08.022
- Sommerfeld, L. C., Holmes, A. P., Yu, T. Y., O'Shea, C., Kavanagh, D. M., Pike, J. M., Wright, T., Syeda, F., Aljehani, A., Kew, T., Cardoso, V. R., Kabir, S. N., Hepburn, C., Menon, P. R., Broadway-Stringer, S., O'Reilly, M., Witten, A., Fortmueller, L., Lutz, S., ... Fabritz, L. (2024). Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse. Journal of Physiology, 602(18), 4409-4436. https://doi.org/10.1113/JP284597
- Graafsma, J., van de Garde, E. M. W., Derijks, H. J., Hoge, R. H. L., Klopotowska, J. E., Karapinar-Carkit, F., van den Bemt, P. M. L. A., & Dutch CDSS-efficiency study group (2024). Efficiency of computerized clinical decision support systems involving anticoagulants: A flashmob study in Dutch hospital pharmacies. British Journal of Clinical Pharmacology, Article 16236. https://doi.org/10.1111/bcp.16236
- Veugen, J. M. J., Schoenmakers, T., van Loo, I. H. M., Haagmans, B. L., Leers, M. P. G., Lamers, M. M., Lucchesi, M., van Bussel, B. C. T., van Mook, W. N. K. A., Nuijts, R. M. M. A., Savelkoul, P. H. M., Dickman, M. M., & Wolffs, P. F. G. (2024). Advancing COVID-19 diagnostics: rapid detection of intact SARS-CoV-2 using viability RT-PCR assay. Microbiology spectrum, 12(9), e0016024. https://doi.org/10.1128/spectrum.00160-24
- Vroemen, W. H. M., Denessen, E. J. S., van Doorn, W. P. T. M., Pelzer, K. E. J. M., Hackeng, T. M., Litjens, E. J. R., Henskens, Y. M. C., van der Sande, F. M., Wodzig, W. K. W. H., Kooman, J. P., Bekers, O., de Boer, D., & Mingels, A. M. A. (2024). Differences in Cardiac Troponin T Composition in Myocardial Infarction and End-Stage Renal Disease Patients: A Blood Tube Effect?Journal of Applied Laboratory Medicine, 9(5), 989-1000. https://doi.org/10.1093/jalm/jfae052
- van de Koolwijk, A. F., Delnoij, T. S. R., Suverein, M. M., Essers, B. A. B., Hermanides, R. C., Otterspoor, L. C., Elzo Kraemer, C. V., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C. A., Dos Reis Miranda, D., Akin, S., de Metz, J., van der Horst, I. C. C., Winkens, B., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial. Resuscitation Plus, 19, Article 100669. https://doi.org/10.1016/j.resplu.2024.100669
- Keulen, G. M., Huckriede, J., Wichapong, K., & Nicolaes, G. A. F. (2024). Histon activities in the extracellular environment: regulation and prothrombotic implications. Current Opinion in Hematology, 31(5), 230-237. https://doi.org/10.1097/MOH.0000000000000827
- Mohammad, A. K., Hugtenburg, J. G., Vanhommerig, J. W., van den Bemt, P. M. L. A., Denig, P., & Karapinar-Carkit, F. (2024). Identifying and quantifying potentially problematic prescribing cascades in clinical practice: A mixed-methods study. Journal of the American Geriatrics Society. Advance online publication. https://doi.org/10.1111/jgs.19191
- Ghossein, M. A., de Kok, J. W. T. M., Eerenberg, F., van Rosmalen, F., Boereboom, R., Duisberg, F., Verharen, K., Sels, J. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., Meex, S. J. R., van Kuijk, S. M. J., van Stipdonk, A. M. W., Ghossein, C., Prinzen, F. W., van der Horst, I. C. C., Vernooy, K., van Bussel, B. C. T., & Driessen, R. G. H. (2024). Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort. Annals of Noninvasive Electrocardiology, 29(5), Article e70001. https://doi.org/10.1111/anec.70001
- de Kok, J., van Bussel, B. C. T., van der Horst, I., & van Rosmalen, F. (2024). Improved reporting of selection processes in clinical database research; author's reply. Journal of Clinical Epidemiology, 173, Article 111394. https://doi.org/10.1016/j.jclinepi.2024.111394
- Diaz, R. V., Munsch, G., Iglesias, M. J., Robles, A. P., Ibrahim-Kosta, M., Nourse, J., Khan, E., Castoldi, E., Saut, N., Boland, A., Germain, M., Deleuze, J.-F., Odeberg, J., Morange, P.-E., Danckwardt, S., Tregouët, D.-A., & Goumidi, L. (2024). Plasma levels of Complement components C5 and C9 are associated with thrombin generation. Journal of Thrombosis and Haemostasis, 22(9), 2531-2542. https://doi.org/10.1016/j.jtha.2024.04.026
- Heines, S. J. H., de Jongh, S. A. M., de Jongh, F. H. C., Segers, R. P. J., Gilissen, K. M. H., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2024). A novel positive end-expiratory pressure titration using electrical impedance tomography in spontaneously breathing acute respiratory distress syndrome patients on mechanical ventilation: an observational study from the MaastrICCht cohort. Journal of Clinical Monitoring and Computing. Advance online publication. https://doi.org/10.1007/s10877-024-01212-8
- Gulikers, J. L., Otten, L.-S., Hendriks, L. E. L., Winckers, K., Henskens, Y., Leentjens, J., van den Heuvel, M. M., Ter Heine, R., Croes, S., Piet, B., & van Geel, R. M. J. M. (2024). Proactive monitoring of drug-drug interactions between direct oral anticoagulants and small-molecule inhibitors in patients with non-small cell lung cancer. British Journal of Cancer, 131(3), 481-490. https://doi.org/10.1038/s41416-024-02744-1
- Rahman, R. N., Polinder, S., Nikolik, B., Hoek, A. E., Janssen, M. J. A., Schuit, S. C. E., van den Bemt, P. M. L. A., & Karapinar-Carkit, F. (2024). Medication reviews by emergency department pharmacists in patients hospitalised for an adverse drug event: a cost study. BMC Health Services Research, 24(1), Article 975. https://doi.org/10.1186/s12913-024-11346-9
- Heuts, S., Bova, R., Romeo, J. L. R., Vriesendorp, P. A., Van Der Horst, I. C. C., Segers, P., Maessen, J. G., Gollman-Tepeköylü, C., Van 't Hof, A. W. J., Bidar, E., & Lux, A. (2024). The prognostic impact of unplanned invasive coronary angiography following coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery, 66(2), Article ezae304. https://doi.org/10.1093/ejcts/ezae304
- Romeo, J. L., Vriesendorp, P. A., Gerritsen, K., Nader, M., Mahtab, E., Maessen, J. G., van 't Hof, A. W. J., Gollmann-Tepeköylü, C., van Rosmalen, F., van der Horst, I. C. C., Mingels, A. M. A., & Heuts, S. (2024). Modeling creatine-kinase MB concentrations following coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. Advance online publication. https://doi.org/10.1016/j.jtcvs.2024.08.019
- Al Ali, L., Meijers, W. C., Beldhuis, I. E., Groot, H. E., Lipsic, E., van Veldhuisen, D. J., Voors, A. A., van der Horst, I. C. C., de Boer, R. A., & van der Harst, P. (2024). Association of fibrotic markers with diastolic function after STEMI. Scientific Reports, 14(1), Article 19122. https://doi.org/10.1038/s41598-024-69926-y
- Bels, J. L. M., Thiessen, S., van Gassel, R. J. J., Beishuizen, A., De Bie Dekker, A., Fraipont, V., Lamote, S., Ledoux, D., Scheeren, C., De Waele, E., van Zanten, A. R. H., Bormans-Russell, L., van Bussel, B. C. T., Dictus, M. M. J., Fivez, T., Harks, I., van der Horst, I. C. C., Jonckheer, J., Marechal, H., ... PRECISe study team (2024). Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands. Lancet, 404(10453), 659-669. https://doi.org/10.1016/S0140-6736(24)01304-7
- Bels, J. L. M., Thiessen, S., van Gassel, R. J. J., Beishuizen, A., Dekker, A. D. B., Fraipont, V., Lamote, S., Ledoux, D., Scheeren, C., De Waele, E., van Zanten, A. R. H., Bormans-Russell, L., van Bussel, B. C. T., Dictus, M. M. J., Fivez, T., Harks, I., van der Horst, I. C. C., Jonckheer, J., Marechal, H., ... PRECISe study team (2024). Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlledtrial in Belgium and the Netherlands. Lancet, 404(10453), 659-669. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01304-7/fulltext
- Baidildinova, G., Ten Cate, V., Panova-Noeva, M., Dahlen, B., Gieswinkel, A., von Ungern-Sternberg, S., Rapp, S., Strauch, K., Beutel, M. E., Pfeiffer, N., Lackner, K. J., Münzel, T., Ten Cate, H., Wild, P. S., & Jurk, K. (2024). Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study. Blood advances, 8(15), 3870-3874. https://doi.org/10.1182/bloodadvances.2023012538
- van der Mee, F. A. M., Schaper, F., Jansen, J., Bons, J. A. P., Meex, S. J. R., & Cals, J. W. L. (2024). Enhancing Patient Understanding of Laboratory Test Results: Systematic Review of Presentation Formats and Their Impact on Perception, Decision, Action, and Memory. Journal of Medical Internet Research, 26, Article e53993. https://doi.org/10.2196/53993
- Reyat, J. S., Sommerfeld, L. C., O'Reilly, M., Cardoso, V. R., Thiemann, E., Khan, A. O., O'Shea, C., Harder, S., Müller, C., Barlow, J., Stapley, R. J., Chua, W., Kabir, S. N., Grech, O., Hummel, O., Hübner, N., Kääb, S., Mont, L., Hatem, S. N., ... Fabritz, L. (2024). PITX2 deficiency leads to atrial mitochondrial dysfunction. Cardiovascular Research. Advance online publication. https://doi.org/10.1093/cvr/cvae169
- Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., & Schotten, U. (2024). Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery. Heart Rhythm. Advance online publication. https://doi.org/10.1016/j.hrthm.2024.08.014
- Chiarini, G., Mariani, S., Schaefer, A.-K., van Bussel, B. C. T., Di Mauro, M., Wiedemann, D., Saeed, D., Pozzi, M., Botta, L., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Buscher, H., Salazar, L., Meyns, B., Herr, D., Matteucci, S., ... Post-Cardiotomy Extracorporeal Life Support (PELS-1) Investigators (2024). Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study. Critical Care, 28(1), Article 265. https://doi.org/10.1186/s13054-024-05047-2
- Haisma, B., Schols, S. E. M., van Oerle, R. G. M., Verbeek-Knobbe, K., Hellenbrand, D., Verwoerd, E. J., Heubel-Moenen, F. C. J. I., Stroobants, A. K., Meijer, D., Rijpma, S. R., & Henskens, Y. M. C. (2024). Comparative analysis of thrombin generation platforms for patients with coagulation factor deficiencies: A comprehensive assessment. Thrombosis Research, 240, Article 109045. https://doi.org/10.1016/j.thromres.2024.109045
- Luu, I. H. Y., Appelboom, Y., Willems, J. I. A., Gielen, R. J. C. A. M., Lobbes, M. B. I., Külcü, K., ten Cate, H., Peeters, J., Palmen, J., Buijs, J., Jie, K. S. G., van Kampen, R. J. W., Mostard, G. J. M., & van Twist, D. J. L. (2024). Deferring diagnostic evaluation of suspected deep vein thrombosis using direct oral anticoagulant or low-molecular-weight heparin as a single dose anticoagulant: A prospective real-world study in a regionwide care pathway. Thrombosis Research, 240, Article 109059. https://doi.org/10.1016/j.thromres.2024.109059
- Monegatti, S., Martinelli, N., Friso, S., Spronk, H. M., & Ten Cate, H. (2024). Mechanisms and management of thrombosis in cancer: focus on gastrointestinal malignancies. Journal of Pharmacology and Experimental Therapeutics, 390(2). https://doi.org/10.1124/jpet.124.002203
- Hesselink, G., Verhage, R., Westerhof, B., Verweij, E., Fuchs, M., Janssen, I., van der Meer, C., van der Horst, I. C. C., de Jong, P., van der Hoeven, J. G., & Zegers, M. (2024). Reducing administrative burden by implementing a core set of quality indicators in the ICU: a multicentre longitudinal intervention study. BMJ Quality and Safety, Article bmjqs-2024-017481. Advance online publication. https://doi.org/10.1136/bmjqs-2024-017481
- Mencke, R., Al Ali, L., de Koning, M.-S. L. Y., Pasch, A., Minnion, M., Feelisch, M., van Veldhuisen, D. J., van der Horst, I. C. C., Gansevoort, R. T., Bakker, S. J. L., de Borst, M. H., van Goor, H., van der Harst, P., Lipsic, E., & Hillebrands, J.-L. (2024). Serum Calcification Propensity Is Increased in Myocardial Infarction and Hints at a Pathophysiological Role Independent of Classical Cardiovascular Risk Factors. Arteriosclerosis Thrombosis and Vascular Biology, 44(8), 1884-1894. https://doi.org/10.1161/ATVBAHA.124.320974
- Falke, C., Karapinar, F., Bouvy, M., Emmelot, M., Belitser, S., Boland, B., O'Mahony, D., Murphy, K. D., Haller, M., Salari, P., Schwenkglenks, M., Rodondi, N., Egberts, T., & Knol, W. (2024). The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy. European Geriatric Medicine. https://doi.org/10.1007/s41999-024-01036-4
- Willers, V., Krumeich, J. R. L., Hulshof, A.-M., Buise, M. P., van der Horst, I. C. C., Henskens, Y. M. C., van Bussel, B. C. T., & Kuiper, G. J. A. J. M. (2024). Comparison of the Quantra QPlus and ROTEM Goal-Directed Transfusion Protocols in Cardiothoracic Surgery Patients: A Prospective Observational Study. Journal of Cardiothoracic and Vascular Anesthesia, 38(11), 2559-2566. Advance online publication. https://doi.org/10.1053/j.jvca.2024.07.046
- de Kok, J. W. T. M., van Bussel, B. C. T., Schnabel, R., van Herpt, T. T. W., Driessen, R. G. H., Meijs, D. A. M., Goossens, J. A., Mertens, H. J. M. M., van Kuijk, S. M. J., Wynants, L., van der Horst, I. C. C., & van Rosmalen, F. (2024). Corrigendum to Table 0; documenting the steps to go from clinical database to research dataset Journal of Clinical Epidemiology Volume 170 (2024) 111342. Journal of Clinical Epidemiology, 172, Article 111436. https://doi.org/10.1016/j.jclinepi.2024.111436
- Rademakers, T., Manca, M., Jin, H., Orban, T., Perisic, L. M., Frissen, H. J. M., Rühle, F., Hautvast, P., van Rijssel, J., van Kuijk, K., Mees, B. M. E., Peutz-Kootstra, C. J., Heeneman, S., Daemen, M. J. A. P., Pasterkamp, G., Stoll, M., van Zandvoort, M. A. M. J., Hedin, U., Dequiedt, F., ... Biessen, E. A. L. (2024). Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype. Angiogenesis, 27(3), 461-474. https://doi.org/10.1007/s10456-024-09921-z
- Schreuder, M., Jourdi, G., Veizaj, D., Poole, D. A., Cheung, K. L., Poenou, G., Verhoef, D., Thomassen, S., Janssen, L. F. H., Stepanian, A., Hackeng, T. M., Gaussem, P., Reitsma, P. H., Geerke, D. P., Siguret, V., & Bos, M. H. A. (2024). Minimally Modified Human Blood Coagulation Factor X to Bypass Direct Factor Xa Inhibitors. Journal of Thrombosis and Haemostasis, 22(8), 2211-2226. https://doi.org/10.1016/j.jtha.2024.04.022
- Kruik-Kollöffel, W. J., Moltman, G. A. W., Wu, M. D., Braaksma, A., Karapinar, F., & Boucherie, R. J. (2024). Optimisation of medication reconciliation using queueing theory: a computer experiment. International Journal of Clinical Pharmacy, 46(4), 881-888. https://doi.org/10.1007/s11096-024-01722-0
- Heuts, S., Ubben, J. F. H., Kawczynski, M. J., Gabrio, A., Suverein, M. M., Delnoij, T. S. R., Kavalkova, P., Rob, D., Komárek, A., van der Horst, I. C. C., Maessen, J. G., Yannopoulos, D., Belohlávek, J., Lorusso, R., & van de Poll, M. C. G. (2024). Extracorporeal cardiopulmonary resuscitation versus standard treatment for refractory out-of-hospital cardiac arrest: a Bayesian meta-analysis. Critical Care, 28(1), Article 217. https://doi.org/10.1186/s13054-024-05008-9
- Ippel, H., Miller, M. C., Dings, R. P. M., Ludwig, A.-K., Gabius, H.-J., & Mayo, K. H. (2024). Cysteine Oxidation in Human Galectin-1 Occurs Sequentially via a Folded Intermediate to a Fully Oxidized Unfolded Form. International Journal of Molecular Sciences, 25(13), Article 6956. https://doi.org/10.3390/ijms25136956