• 2017
    • Baaten, C. C. F. M. J., ten Cate, H., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2017). Platelet populations and priming in hematological diseases. Blood Reviews, 31(6), 389-399. https://doi.org/10.1016/j.blre.2017.07.004
    • Honickel, M., Braunschweig, T., Rossaint, R., Stoppe, C., ten Cate, H., & Grottke, O. (2017). Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma. Anesthesiology, 127(5), 852-861. https://doi.org/10.1097/ALN.0000000000001856
    • Vroemen, W. H. M., de Boer, D., Streng, A. S., Bekers, O., & Wodzig, W. K. W. H. (2017). Thrombin Activation via Serum Preparation Is Not the Root Cause for Cardiac Troponin T Degradation. Clinical Chemistry, 63(11), 1768-1769. https://doi.org/10.1373/clinchem.2017.279182
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Dagnelie, P. C., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2017). Cardiovascular risk factors as determinants of retinal and skin microvascular function: The Maastricht Study. PLOS ONE, 12(10), Article e0187324. https://doi.org/10.1371/journal.pone.0187324
    • Olie, R. H., Meertens, N. E. L., Henskens, Y. M. C., & ten Cate, H. (2017). Empirically Reduced Dosages of Tinzaparin in Patients with Moderate-to-Severe Renal Insufficiency Lead to Inadequate Anti-Xa Levels. The Nephron Journals, 137(2), 113-123. https://doi.org/10.1159/000477474
    • Nuzzo, F., Beshlawi, I., Wali, Y., & Castoldi, E. (2017). High incidence of intracranial bleeding in factor V-deficient patients with homozygous F5 splicing mutations. British Journal of Haematology, 179(1), 163-166. https://doi.org/10.1111/bjh.14195
    • Raffa, G. M., Gelsomino, S., Sluijpers, N., Meani, P., Alenizy, K., Natour, E., Bidar, E., Johnson, D. M., Makhoul, M., Heuts, S., Lozekoot, P., Kats, S., Schreurs, R., Delnoij, T., Montalti, A., Sels, J. W., Poll, M. V. D., Roekaerts, P., Maessen, J., & Lorusso, R. (2017). In-hospital outcome of post-cardiotomy extracorporeal life support in adult patients: the 2007-2017 Maastricht experience. Critical Care and Resuscitation, 19(Suppl 1), 53-61. http://cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR%20Journal/Previous%20Editions/October%20Supplement%202017/ccr_19_OctSupp_011017-S53-S61.pdf
    • van der Linden, N., Hilderink, J. M., Cornelisa, T., Kimenai, D. M., Klinkenbergb, L. J. J., van Doorn, W. P., Litjens, E. J. R., van Suijlen, J. D. E., van Loon, L. J. C., Bekers, O., Kooman, J. P., & Meex, S. J. R. (2017). Twenty-Four-Hour Biological Variation Profiles of Cardiac Troponin I in Individuals with or without Chronic Kidney Disease. Clinical Chemistry, 63(10), 1655-1656. https://doi.org/10.1373/clinchem.2017.275107
    • Scheepers, L. E. J. M., Boonen, A., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Henry, R. M. A., Kroon, A. A., Stehouwer, C. D. A., & Arts, I. C. W. (2017). Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study. Journal of Hypertension, 35(10), 1968-1975. https://doi.org/10.1097/HJH.0000000000001417
    • Heinig, M., Adriaens, M. E., Schafer, S., van Deutekom, H. W. M., Lodder, E. M., Ware, J. S., Schneider, V., Felkin, L. E., Creemers, E. E., Meder, B., Katus, H. A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N. H., George, A. L., ... Hubner, N. (2017). Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biology, 18(1), Article 170. https://doi.org/10.1186/s13059-017-1286-z
    • van der Linden, N., Cornelis, T., Kimenai, D. M., Klinkenberg, L. J. J., Hilderink, J. M., Luck, S., Litjens, E. J. R., Peeters, F. E. C. M., Streng, A. S., Breidthardt, T., van Loon, L. J. C., Bekers, O., Kooman, J. P., Westermark, P. O., Mueller, C., & Meex, S. J. R. (2017). Origin of Cardiac Troponin T Elevations in Chronic Kidney. Circulation, 136(11), 1073-1075. https://doi.org/10.1161/CIRCULATIONAHA.117.029986
    • Hilderink, J. M., Rennenberg, R. J. M. W., Vanmolkot, F. H. M., Bekers, O., Koopmans, R. P., & Meex, S. J. R. (2017). Labtracker plus , a medical smartphone app for the interpretation of consecutive laboratory results: an external validation study. BMJ Open, 7(9), Article 015854. https://doi.org/10.1136/bmjopen-2017-015854
    • Martens, R. J. H., Geijselaers, S. L. C., Stehouwer, C. D. A., Henry, R. M. A., & Maastricht Study Group (2017). Timing of syncope during blood sampling-The Maastricht Study. European journal of internal medicine, 43, E46-E47. https://doi.org/10.1016/j.ejim.2017.05.024
    • Zhao, Z., Vajen, T., Karshovska, E., Dickhout, A., Schmitt, M. M., Megens, R. T. A., von Hundelshausen, P., Koeppel, T. A., Hackeng, T. M., Weber, C., & Koenen, R. R. (2017). Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. Journal of Cellular and Molecular Medicine, 21(8), 1523-1531. https://doi.org/10.1111/jcmm.13083
    • Christophersen, I. E., Magnani, J. W., Yin, X., Barnard, J., Weng, L.-C., Arking, D. E., Niemeijer, M. N., Lubitz, S. A., Avery, C. L., Duan, Q., Felix, S. B., Bis, J. C., Kerr, K. F., Isaacs, A., Mueller-Nurasyid, M., Mueller, C., North, K. E., Reiner, A. P., Tinker, L. F., ... Ellinor, P. T. (2017). Fifteen Genetic Loci Associated With the Electrocardiographic P Wave. Circulation : Cardiovascular Genetics, 10(4), Article 001667. https://doi.org/10.1161/CIRCGENETICS.116.001667
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Reesink, K. D., Dagnelie, P. C., Schaper, N. C., Schalkwijk, C. G., Schram, M. T., & Stehouwer, C. D. A. (2017). Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study. Diabetes Care, 40(8), e103-e105. https://doi.org/10.2337/dc17-0574
    • van der Huller, T., van Es, N., den Exter, P. L., van Es, J., Mos, I. C. M., Douma, R. A., Kruip, M. J. H. A., Hovens, M. M. C., ten Woldes, M., Nijkeuter, M., ten Cate, H., Kamphuisen, P. W., BuIler, H. R., Huisman, M. V., & Klok, F. A. (2017). Is a normal computed tomography pulmonary angiography safe to rule out acute pulmonary embolism in patients with a likely clinical probability?Thrombosis and Haemostasis, 117(8), 1622-1629. https://doi.org/10.1160/TH17-02-0076
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., ten Cate-Hoek, A., & Burden, A. M. (2017). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. British Journal of Clinical Pharmacology, 83(8), 1835-1843. https://doi.org/10.1111/bcp.13264
    • Van der Velde, J. H. P. M., Koster, A., Van der Berg, J. D., Sep, S. J. S., Van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Eussen, S. J. P. M., Van Dongen, M. C. J. M., Stehouwer, C. D. A., Schaper, N. C., & Savelberg, H. H. C. M. (2017). Sedentary Behavior, Physical Activity, and Fitness-The Maastricht Study. Medicine and Science in Sports and Exercise, 49(8), 1583-1591. https://doi.org/10.1249/MSS.0000000000001262
    • de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., & van den Bergh, J. P. W. (2017). The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study. Bone, 101, 156-161. https://doi.org/10.1016/j.bone.2017.05.004
    • Elissen, A. M. J., Hertroijs, D. F. L., Schaper, N. C., Bosma, H., Dagnelie, P. C., Henry, R. M., van der Kallen, C. J., Koster, A., Schram, M. T., Stehouwer, C. D. A., Schouten, J. S. A. G., Berendschot, T. T. J. M., & Ruwaard, D. (2017). Differences in biopsychosocial profiles of diabetes patients by level of glycaemic control and health-related quality of life: The Maastricht Study. PLOS ONE, 12(7), Article e0182053. https://doi.org/10.1371/journal.pone.0182053
    • Kimenai, D. M., Martens, R. J. H., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Schaper, N. C., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Sep, S. J. S., van Suijlen, J. D. E., Kroon, A. A., Bekers, O., van Dieijen-Visser, M. P., Henry, R. M. A., & Meex, S. J. R. (2017). Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study. Scientific Reports, 7(1), Article 6610. https://doi.org/10.1038/s41598-017-06978-3
    • Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroeder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., ... Weber, C. (2017). Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies. Circulation, 136(4), 388-403. https://doi.org/10.1161/CIRCULATIONAHA.117.027646
    • Prochaska, J. H., Frank, B., Nagler, M., Lamparter, H., Weisser, G., Schulz, A., Eggebrecht, L., Goebel, S., Arnold, N., Panova-Noeva, M., Hermanns, I., Pinto, A., Konstantinides, S., ten Cate, H., Lackner, K. J., Muenzel, T., Espinola-Klein, C., & Wild, P. S. (2017). Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific Reports, 7(1), Article 4591. https://doi.org/10.1038/s41598-017-04843-x
    • Sabrkhany, S., Kuijpers, M. J. E., van Kuijk, S. M. J., Sanders, L., Pineda, S., Damink, S. W. M. O., Dingemans, A.-M. C., Griffioen, A. W., & Egbrink, M. G. A. O. (2017). A combination of platelet features allows detection of early-stage cancer. European Journal of Cancer, 80, 5-13. https://doi.org/10.1016/j.ejca.2017.04.010
    • Orsini, S., Noris, P., Bury, L., Heller, P. G., Santoro, C., Kadir, R. A., Butta, N. C., Falcinelli, E., Cid, A. R., Fabris, F., Fouassier, M., Miyazaki, K., Luisa Lozano, M., Zuniga, P., Flaujac, C., Podda, G. M., Bermejo, N., Favier, R., Henskens, Y., ... EHA-SWG Thrombocytopenias Platelet (2017). Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. Haematologica-the Hematology Journal, 102(7), 1192-1203. https://doi.org/10.3324/haematol.2016.160754
    • ten Cate, H., Hackeng, T. M., & de Frutos, P. G. (2017). Coagulation factor and protease pathways in thrombosis and cardiovascular disease. Thrombosis and Haemostasis, 117(7), 1265-1271. https://doi.org/10.1160/TH17-02-0079
    • Honickel, M., Spronk, H. M., Rossaint, R., Stoppe, C., van Ryn, J., ten Cate, H., & Grottke, O. (2017). Dose requirements for idarucizumab reversal of dabigatran in a lethal porcine trauma model with continuous bleeding. Thrombosis and Haemostasis, 117(7), 1370-1378. https://doi.org/10.1160/TH16-11-0824
    • Prochaska, J. H., Goebel, S., Keller, K., Coldewey, M., Ullmann, A., Lamparter, H., Schulz, A., Schinzel, H., Bickel, C., Lauterbach, M., Michal, M., Hardt, R., Binder, H., Espinola-Klein, C., Lackner, K. J., Ten Cate, H., Muenzel, T., & Wild, P. S. (2017). e-Health-based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study. Journal of Thrombosis and Haemostasis, 15(7), 1375-1385. https://doi.org/10.1111/jth.13727
    • van der Linden, N., Streng, A. S., Bekers, O., Wodzig, W. K. W. H., Meex, S. J. R., & de Boer, D. (2017). Large Variation in Measured Cardiac Troponin T Concentrations after Standard Addition in Serum or Plasma of Different Individuals. Clinical Chemistry, 63(7), 1300-1302. https://doi.org/10.1373/clinchem.2017.272435
    • Ridger, V. C., Boulanger, C. M., Angelillo-Scherrer, A., Badimon, L., Blanc-Brude, O., Bochaton-Piallat, M.-L., Boilard, E., Buzas, E. I., Caporali, A., Dignat-George, F., Evans, P. C., Lacroix, R., Lutgens, E., Ketelhuth, D. F. J., Nieuwland, R., Toti, F., Tunon, J., Weber, C., Hoefer, I. E., ... Harrison, P. (2017). Microvesicles in vascular homeostasis and diseases Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thrombosis and Haemostasis, 117(7), 1296-1316. https://doi.org/10.1160/TH16-12-0943
    • Hilderink, J. M., Klinkenberg, L. J. J., Aakre, K. M., de Wit, N. C. J., Henskens, Y. M. C., van der Linden, N., Bekers, O., Rennenberg, R. J. M. W., Koopmans, R. P., & Meex, S. J. R. (2017). Within-day biological variation and hour-to-hour reference change values for hematological parameters. Clinical Chemistry and Laboratory Medicine, 55(7), 1013-1024. https://doi.org/10.1515/cclm-2016-0716
    • Schmidt, M., Toplak, A., Quaedflieg, P. J. L. M., Ippel, H., Richelle, G. J. J., Hackeng, T. M., van Maarseveen, J. H., & Nuijens, T. (2017). Omniligase-1: A Powerful Tool for Peptide Head-to-Tail Cyclization. Advanced Synthesis & Catalysis, 359(12), 2050-2055. https://doi.org/10.1002/adsc.201700314
    • van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y.-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Mueller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., ... Munroe, P. B. (2017). Discovery of novel heart rate-associated loci using the Exome Chip. Human Molecular Genetics, 26(12), 2346-2363. https://doi.org/10.1093/hmg/ddx113
    • Arts, M., Soons, Z., Ellis, S. R., Pierzchalski, K. A., Balluff, B., Eijkel, G. B., Dubois, L. J., Lieuwes, N. G., Agten, S. M., Hackeng, T. M., van Loon, L. J. C., Heeren, R. M. A., & Damink, S. W. M. O. (2017). Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. Angewandte Chemie-International Edition, 56(25), 7146-7150. https://doi.org/10.1002/anie.201702669
    • Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J., & Koenen, R. R. (2017). Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype. Journal of Extracellular Vesicles, 6(1), Article 1322454. https://doi.org/10.1080/20013078.2017.1322454
    • Oshagbemi, O. A., Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., Maitland-van der Zee, A. H., de Vries, F., & Franssen, F. M. E. (2017). Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. American Journal of Respiratory and Critical Care Medicine, 195(10), 1402-1404. https://doi.org/10.1164/rccm.201701-0009LE
    • Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G., & Lutgens, E. (2017). Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. Journal of Neuroinflammation, 14(1), Article 105. https://doi.org/10.1186/s12974-017-0875-9
    • Van Der Linden, N., Streng, A. S., Wodzig, W. K. W. H., Bekers, O., & Meex, S. J. R. (2017). Better, higher, lower, faster: increasingly rapid clinical decision making using high-sensitivity cardiac troponin assays. Journal of Laboratory and Precision Medicine, 2, Article 14. https://doi.org/10.21037/jlpm.2017.04.03
    • Kremers, R. M. W., Kleinegris, M.-C., Ninivaggi, M., de Laat, B., ten Cate, H., Koek, G. H., Wagenvoord, R. J., & Hemker, H. C. (2017). Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis. PLOS ONE, 12(5), Article 0177020. https://doi.org/10.1371/journal.pone.0177020
    • Bloemen, S., Zwaveling, S., ten Cate, H., ten Cate-Hoek, A., & de Laat, B. (2017). Prediction of bleeding risk in patients taking vitamin K antagonists using thrombin generation testing. PLOS ONE, 12(5), Article e0176967. https://doi.org/10.1371/journal.pone.0176967
    • Westhoff, C. L., Pike, M. C., Cremers, S., Eisenberger, A., Thomassen, S., & Rosing, J. (2017). Endogenous thrombin potential changes during the first cycle of oral contraceptive use. Contraception, 95(5), 456-463. https://doi.org/10.1016/j.contraception.2017.01.001
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., Henry, R. M. A., Verhey, F. R. J., Kroon, A. A., Schaper, N. C., Dagnelie, P. C., Kallen, C. J. H. V. D., Stehouwer, C. D. A., & Biessels, G. J. (2017). Insulin resistance and cognitive performance in type 2 diabetes - The Maastricht study. Journal of Diabetes and Its Complications, 31(5), 824-830. https://doi.org/10.1016/j.jdiacomp.2017.01.020
    • Meani, P., Gelsomino, S., Natour, E., Johnson, D. M., Rocca, H.-P. B. L., Pappalardo, F., Bidar, E., Makhoul, M., Raffa, G., Heuts, S., Lozekoot, P., Kats, S., Sluijpers, N., Schreurs, R., Delnoij, T., Montalti, A., Sels, J. W., van de Poll, M., Roekaerts, P., ... Lorusso, R. (2017). Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature. European journal of heart failure, 19 Suppl 2, 84-91. https://doi.org/10.1002/ejhf.850
    • Alshaikh, N. A., Rosing, J., Thomassen, M. C. L. G. D., Castoldi, E., Simioni, P., & Hackeng, T. M. (2017). New functional assays to selectively quantify the activated protein C- and tissue factor pathway inhibitor-cofactor activities of protein S in plasma. Journal of Thrombosis and Haemostasis, 15(5), 950-960. https://doi.org/10.1111/jth.13657
    • Veugen, M. G. J., Henry, R. M. A., van Sloten, T. T., Hermeling, E., Brunner-La Rocca, H.-P., Schram, M. T., Dagnelie, P. C., Schalkwijk, C. G., Kroon, A. A., Stehouwer, C. D. A., & Reesink, K. D. (2017). The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study. Journal of Hypertension, 35(5), 1052-1060. https://doi.org/10.1097/HJH.0000000000001298
    • van der Velde, J. H. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Sep, S. J. S., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Reijven, P. L. M., van Geel, T. A. C. M., Stehouwer, C. D. A., Koster, A., & Schaper, N. C. (2017). Sedentary Behavior Is Only Marginally Associated with Physical Function in Adults Aged 40-75 Years - the Maastricht Study. Frontiers in physiology, 8(APR), Article 242. https://doi.org/10.3389/fphys.2017.00242
    • Kleinegris, M.-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J., & ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in Cardiovascular Medicine, 4, Article 23. https://doi.org/10.3389/fcvm.2017.00023
    • Hobbelt, A. H., Spronk, H. M., Crijns, H. J. G. M., Ten Cate, H., Rienstra, M., & Van Gelder, I. C. (2017). Prethrombotic State in Young Very Low- Risk Patients With Atrial Fibrillation. Journal of the American College of Cardiology, 69(15), 1990-1992. https://doi.org/10.1016/j.jacc.2017.01.057
    • von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., ... Weber, C. (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine, 9(384), Article eaah6650. https://doi.org/10.1126/scitranslmed.aah6650