• 2016
    • Sörensen, B., Houben, B., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Sep, S. J. S., Dagnelie, P. C., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2016). Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction The Maastricht Study. Circulation, 134(18), 1339-1352. https://doi.org/10.1161/CIRCULATIONAHA.116.023446
    • Wentink, M. Q., Hackeng, T. M., Tabruyn, S. P., Puijk, W. C., Schwamborn, K., Altschuh, D., Meloen, R. H., Schuurman, T., Griffioen, A. W., & Timmerman, P. (2016). Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12532-12537. https://doi.org/10.1073/pnas.1610258113
    • Boersma, R. S., Hamulyak, K., van Oerle, R., Tuinenburg, A., Ten Cate - Hoek, A., & Schouten, H. C. (2016). Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies. Clinical and Applied Thrombosis-Hemostasis, 22(8), 779-784. https://doi.org/10.1177/1076029615579098
    • Iotchkova, V., Huang, J., Morris, J. A., Jain, D., Barbieri, C., Walter, K., Min, J. L., Chen, L., Astle, W., Cocca, M., Deelen, P., Elding, H., Farmaki, A.-E., Franklin, C. S., Franberg, M., Gaunt, T. R., Hofman, A., Jiang, T., Kleber, M. E., ... Soranzo, N. (2016). Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics, 48(11), 1303-1312. https://doi.org/10.1038/ng.3668
    • Zentai, C., Solomon, C., van der Meijden, P. E. J., Spronk, H. M. H., Schnabel, J., Rossaint, R., & Grottke, O. (2016). Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model. Clinical and Applied Thrombosis-Hemostasis, 22(8), 749-759. https://doi.org/10.1177/1076029615584662
    • Radu, C. M., Spiezia, L., Bulato, C., Gavasso, S., Campello, E., Sartorello, F., Castoldi, E., & Simioni, P. (2016). Endocytosis of exogenous factor V by ex-vivo differentiated megakaryocytes from patients with severe parahaemophilia. British Journal of Haematology, 175(3), 517-524. https://doi.org/10.1111/bjh.14262
    • de Waard, E. A. C., Koster, A., Melai, T., van Geel, T. A., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Köhler, S., Savelberg, H. H. C. M., Geusens, P. P. M. M., & van den Bergh, J. P. W. (2016). The association between glucose metabolism status, diabetes severity and a history of fractures and recent falls in participants of 50 years and older-the Maastricht Study. Osteoporosis International, 27(11), 3207-3216. https://doi.org/10.1007/s00198-016-3645-0
    • Janssen, E. P. C. J., Köhler, S., Stehouwer, C. D. A., Schaper, N. C., Dagnelie, P. C., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Verhey, F. R., & Schram, M. T. (2016). The Patient Health Questionnaire-9 as a Screening Tool for Depression in Individuals with Type 2 Diabetes Mellitus: The Maastricht Study. Journal of the American Geriatrics Society, 64(11), E201-E206. https://doi.org/10.1111/jgs.14388
    • Haas, S., ten Cate, H., Accetta, G., Angchaisuksiri, P., Bassand, J.-P., Camm, A. J., Corbalan, R., Darius, H., Fitzmaurice, D. A., Goldhaber, S. Z., Goto, S., Jacobson, B., Kayani, G., Mantovani, L. G., Misselwitz, F., Pieper, K., Schellong, S. M., Stepinska, J., Turpie, A. G. G., ... Kakkar, A. K. (2016). Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry. PLOS ONE, 11(10), Article e0164076. https://doi.org/10.1371/journal.pone.0164076
    • van der Linden, N., Cornelis, T., Klinkenberg, L. J. J., Kimenai, D. M., Hilderink, J. M., Litjens, E. J. R., Kooman, J. P., Bekers, O., van Dieijen-Visser, M. P., & Meex, S. J. R. (2016). Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction. International Journal of Cardiology, 221, 287-288. https://doi.org/10.1016/j.ijcard.2016.06.268
    • Marsch, E., Demandt, J. A. F., Theelen, T. L., Tullemans, B. M. E., Wouters, K., Boon, M. R., van Dijk, T. H., Gijbels, M. J., Dubois, L. J., Meex, S. J. R., Mazzone, M., Hung, G., Fisher, E. A., Biessen, E. A. L., Daemen, M. J. A. P., Rensen, P. C. N., Carmeliet, P., Groen, A. K., & Sluimer, J. C. (2016). Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. European Heart Journal, 37(39), 2993-2997. https://doi.org/10.1093/eurheartj/ehw156
    • Bassand, J.-P., Accetta, G., Camm, A. J., Cools, F., Fitzmaurice, D. A., Fox, K. A. A., Goldhaber, S. Z., Goto, S., Haas, S., Hacke, W., Kayani, G., Mantovani, L. G., Misselwitz, F., ten Cate, H., Turpie, A. G. G., Verheugt, F. W. A., & Kakkar, A. K. (2016). Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF. European Heart Journal, 37(38), 2882-2889A. https://doi.org/10.1093/eurheartj/ehw233
    • Evans, D. S., Avery, C. L., Nalls, M. A., Li, G., Barnard, J., Smith, E. N., Tanaka, T., Butler, A. M., Buxbaum, S. G., Alonso, A., Arking, D. E., Berenson, G. S., Bis, J. C., Buyske, S., Carty, C. L., Chen, W., Chung, M. K., Cummings, S. R., Deo, R., ... Sotoodehnia, N. (2016). Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Human Molecular Genetics, 25(19), 4350-4368. https://doi.org/10.1093/hmg/ddw284
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Henry, R. M. A., Reesink, K. D., Kroon, A. A., Koster, A., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2016). Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study. Atherosclerosis, 253, 186-193. https://doi.org/10.1016/j.atherosclerosis.2016.07.912
    • Posma, J. J. N., Posthuma, J. J., & Spronk, H. M. H. (2016). Coagulation and non-coagulation effects of thrombin. Journal of Thrombosis and Haemostasis, 14(10), 1908-1916. https://doi.org/10.1111/jth.13441
    • Solari, F. A., Mattheij, N. J. A., Burkhart, J. M., Swieringa, F., Collins, P. W., Cosemans, J. M. E. M., Sickmann, A., Heemskerk, J. W. M., & Zahedi, R. P. (2016). Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome. Molecular & Cellular Proteomics, 15(10), 3154-3169. https://doi.org/10.1074/mcp.M116.060368
    • Caolo, V., Vries, M., Zupancich, J., Houben, M., Mihov, G., Wagenaar, A., Swennen, G., Nossent, Y., Quax, P., Suylen, D., Dijkgraaf, I., Molin, D., Hackeng, T., & Post, M. (2016). CXCL1 microspheres: a novel tool to stimulate arteriogenesis. Drug Delivery, 23(8), 2919-2926. https://doi.org/10.3109/10717544.2015.1120366
    • van Erning, F. N., Zanders, M. M., Kuiper, J. G., van Herk-Sukel, M. P., Maas, H. A., Vingerhoets, R. W., Zimmerman, D. D., de Feyter, E. P., van de Poll, M. E., & Lemmens, V. E. (2016). Drug dispensings among elderly in the year before colon cancer diagnosis versus matched cancer-free controls. Journal of Clinical Pharmacy and Therapeutics, 41(5), 538-545. https://doi.org/10.1111/jcpt.12434
    • Amin, N., Allebrandt, K. V., van der Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, F. M., Byrne, E. M., Oole, E., Kolcic, I., Chen, T.-H., Evans, D. S., Coresh, J., ... van Duijn, C. M. (2016). Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics, 24(10), 1488-1495. https://doi.org/10.1038/ejhg.2016.31
    • Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M.-H., Chen, T. C., Chen, Y.-D. I., Chung, J., Miglianico, F. D. G., Eriksson, J., Ferrucci, L., ... Kaplan, R. C. (2016). Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell, 15(5), 811-824. https://doi.org/10.1111/acel.12490
    • Regn, M., Laggerbauer, B., Jentzsch, C., Ramanujam, D., Ahles, A., Sichler, S., Calzada-Wack, J., Koenen, R. R., Braun, A., Nieswandt, B., & Engelhardt, S. (2016). Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. Journal of Molecular and Cellular Cardiology, 99, 57-64. https://doi.org/10.1016/j.yjmcc.2016.08.010
    • Cheung, Y. W., Middeldorp, S., Prins, M. H., Pap, A. F., Lensing, A. W. A., Hoek - ten Cate, A., Villalta, S., Milan, M., Beyer-Westendorf, J., Verhamme, P., Bauersachs, R. M., & Prandoni, P. (2016). Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis A post-hoc analysis. Thrombosis and Haemostasis, 116(4), 733-738. https://doi.org/10.1160/TH16-01-0041
    • van Eupen, M. G. A., Schram, M. T., van Sloten, T. T., Scheijen, J., Sep, S. J. S., van der Kallen, C. J., Dagnelie, P. C., Koster, A., Schaper, N., Henry, R. M. A., Kroon, A. A., Smit, A. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016). Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study. Hypertension, 68(4), 956-963. https://doi.org/10.1161/HYPERTENSIONAHA.116.07446
    • Sabrkhany, S., Griffioen, A. W., Pineda, S., Sanders, L., Mattheij, N., van Geffen, A., Aarts, M. J., Heemskerk, J. W. M., Oude Egbrink, M., & Kuijpers, M. J. E. (2016). Sunitinib uptake inhibits platelet function in cancer patients. European Journal of Cancer, 66, 47-54. https://doi.org/10.1016/j.ejca.2016.07.016
    • ten Cate, V., ten Cate, H., & Verheugt, F. W. A. (2016). The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Netherlands Heart Journal, 24(10), 574-580. https://doi.org/10.1007/s12471-016-0874-y
    • Koenen, R. R. (2016). The prowess of platelets in immunity and inflammation. Thrombosis and Haemostasis, 116(4), 605-612. https://doi.org/10.1160/TH16-04-0300
    • van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X. C., Leach, I. M., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikainen, L. P., Polasek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., ... Isaacs, A. (2016). 52 Genetic Loci Influencing Myocardial Mass. Journal of the American College of Cardiology, 68(13), 1435-1448. https://doi.org/10.1016/j.jacc.2016.07.729
    • Willems, S. M., Cornes, B. K., Brody, J. A., Morrison, A. C., Lipovich, L., Dauriz, M., Chen, Y., Liu, C.-T., Rybin, D. V., Gibbs, R. A., Muzny, D., Pankow, J. S., Psaty, B. M., Boerwinkle, E., Rotter, J. I., Siscovick, D. S., Vasan, R. S., Kaplan, R. C., Isaacs, A., ... Meigs, J. B. (2016). Association of the IGF1 gene with fasting insulin levels. European Journal of Human Genetics, 24(9), 1337-1343. https://doi.org/10.1038/ejhg.2016.4
    • Dargaud, Y., Jourdy, Y., Le Quellec, S., Hemker, H., Lindhout, T., Castoldi, E., & Negrier, C. (2016). Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C > A mutation. British Journal of Haematology, 174(6), 993-996. https://doi.org/10.1111/bjh.13833
    • Montero, D., Houben, B., Koster, A., Muris, D. M. J., Schram, M. T., Gronenschild, E. H., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schaper, N. C., Dagnelie, P. C., van Geel, T. A. C. M., Kremers, S. P. J., Savelberg, H. H. C. M., & Stehouwer, C. D. A. (2016). Physical Activity Is Associated With Glucose Tolerance Independent of Microvascular Function: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 101(9), 3324-3332. https://doi.org/10.1210/jc.2016-1526
    • van Bussel, B. C. T., & Koopmans, R. P. (2016). Trousseau's sign at the emergency department. BMJ case Reports, 2016. https://doi.org/10.1136/bcr-2016-216270
    • Arning, A., Jeibmann, A., Koehnemann, S., Brokinkel, B., Ewelt, C., Berger, K., Wellmann, J., Nowak-Goettl, U., Stummer, W., Stoll, M., & Holling, M. (2016). ADAMTS genes and the risk of cerebral aneurysm. Journal of Neurosurgery, 125(2), 269-274. https://doi.org/10.3171/2015.7.JNS154
    • van Dooren, F. E. P., Schram, M. T., Schalkwijk, C. G., Stehouwer, C. D. A., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J. H., Koster, A., Sep, S. J. S., Denollet, J., Verhey, F. R. J., & Pouwer, F. (2016). Associations of low grade inflammation and endothelial dysfunction with depression - The Maastricht Study. Brain Behavior and Immunity, 56, 390-396. https://doi.org/10.1016/j.bbi.2016.03.004
    • Fitzmaurice, D. A., Accetta, G., Haas, S., Kayani, G., Lucas Luciardi, H., Misselwitz, F., Pieper, K., ten Cate, H., Turpie, A. G. G., & Kakkar, A. K. (2016). Comparison of international normalized ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonists. British Journal of Haematology, 174(4), 610-623. https://doi.org/10.1111/bjh.14084
    • ten Cate, H. (2016). Insight MicroRNA studies can help to reveal underlying biological mechanisms that are operational in DVT and its resolution... MicroRNA and venous thrombosis. Thrombosis and Haemostasis, 116(2), 205-205. https://doi.org/10.1160/TH16-06-0473
    • Ippel, H., Miller, M. C., Vertesy, S., Zheng, Y., Javier Canada, F., Suylen, D., Umemoto, K., Romano, C., Hackeng, T., Tai, G., Leffler, H., Kopitz, J., Andre, S., Kuebler, D., Jimenez-Barbero, J., Oscarson, S., Gabius, H.-J., & Mayo, K. H. (2016). Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR. Glycobiology, 26(8), 888-903. https://doi.org/10.1093/glycob/cww021
    • Rühle, F., & Stoll, M. (2016). Long non-coding RNA Databases in Cardiovascular Research. Genomics, Proteomics and Bioinformatics, 14(4), 191–199. https://doi.org/10.1016/j.gpb.2016.03.001
    • ten Cate, H., & Hemker, H. (2016). Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?Journal of the American Heart Association, 5(8), Article e003553. https://doi.org/10.1161/JAHA.116.003553
    • Klinkenberg, L. J. J., Luyten, P., van der Linden, N., Urgel, K., Snijders, D. P. C., Knackstedt, C., Dennert, R., Kietselaer, B. L. J. H., Mingels, A., Cardinaels, E. P. M., Peeters, F. E. C. M., van Suijlen, J. D. E., ten Kate, J., Marsch, E., Theelen, T. L., Sluimer, J. C., Wouters, K., Bekers, O., Bekkers, B., ... Meex, S. J. R. (2016). Cardiac Troponin T and I Release After a 30-km Run. American Journal of Cardiology, 118(2), 281-287. https://doi.org/10.1016/j.amjcard.2016.04.030
    • Loeffen, R. A., van Oerle, R., Leers, M. P. G., Kragten, J. A., Crijns, H., Spronk, H. M. H., & ten Cate, H. (2016). Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events. PLOS ONE, 11(7), Article e0158355. https://doi.org/10.1371/journal.pone.0158355
    • Smulders, M. W., Kietselaer, B. L. J. H., Schalla, S., Bucerius, J., Jaarsma, C., van Dieijen-Visser, M. P., Mingels, A. M. A., Brunner-La Rocca, H., Post, M., Das, M., Crijns, H. J. G. M., Wildberger, J. E., & Bekkers, B. (2016). Acute chest pain in the high-sensitivity cardiac troponin era: A changing role for noninvasive imaging?American Heart Journal, 177, 102-111. https://doi.org/10.1016/j.ahj.2016.03.025
    • Godschalk, T. C., Konings, J., Govers-Riemslag, J., ten Berg, J. M., Hackeng, C. M., & ten Cate, H. (2016). Fibrin clot formation and fibrinolysis in patients with a history of coronary stent thrombosis. Thrombosis Research, 143, 58-62. https://doi.org/10.1016/j.thromres.2016.04.026
    • Zentai, C., van der Meijden, P. E. J., Braunschweig, T., Hueck, N., Honickel, M., Spronk, H. M. H., Rossaint, R., & Grottke, O. (2016). Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury. Anesthesia and Analgesia, 123(1), 38-48. https://doi.org/10.1213/ANE.0000000000001379
    • Pezeshkpoor, B., Castoldi, E., Mahler, A., Hanel, D., Mueller, J., Hamedani, N. S., Biswas, A., Oldenburg, J., & Pavlova, A. (2016). Identification and functional characterization of a novel F5 mutation (Ala512Val, FVBonn) associated with activated protein C resistance. Journal of Thrombosis and Haemostasis, 14(7), 1353-1363. https://doi.org/10.1111/jth.13339
    • van Beers, J. J. B. C., van Egmond, L. T., Wetzels, R. J. H., Verhezen, P. W. M., Beckers, E. A. M., van Oerle, R., Spronk, H. M. H., Straat, R. J. M. H. E., & Henskens, Y. M. C. (2016). Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma. Vox Sanguinis, 111(1), 33-42. https://doi.org/10.1111/vox.12395
    • van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., ... van Duijn, C. M. (2016). Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics, 53(7), 441-449. https://doi.org/10.1136/jmedgenet-2015-103439
    • Van Poucke, S., Zhang, Z., Roest, M., Vukicevic, M., Beran, M., Lauwereins, B., Zheng, M.-H., Henskens, Y., Lance, M., & Marcus, A. (2016). Normalization methods in time series of platelet function assays A SQUIRE compliant study. Medicine, 95(28). https://doi.org/10.1097/MD.0000000000004188
    • Linssen, P. B. C., Henry, R. M. A., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., Brunner-La Rocca, H., & Stehouwer, C. D. A. (2016). Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study. Diabetes & Vascular Disease Research, 13(4), 278-285. https://doi.org/10.1177/1479164116640680
    • Claes, G. R. F., van Tienen, F. H. J., Lindsey, P., Krapels, I. P. C., van den Enden, A., Hoos, M., Barrois, Y. E. G., Janssen, J., Paulussen, A. D. C., Sels, J.-W. E. M., Kuijpers, S. H. H., van Tintelen, J. P., van den Berg, M. P., Heesen, W. F., Garcia-Pavia, P., Perrot, A., Christiaans, I., Salemink, S., Marcelis, C. L. M., ... van den Wijngaard, A. (2016). Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers. European Heart Journal, 37(23), 1815-1822. https://doi.org/10.1093/eurheartj/ehv522
    • Simeoni, I., Stephens, J. C., Hu, F., Deevi, S. V. V., Megy, K., Bariana, T. K., Lentaigne, C., Schulman, S., Sivapalaratnam, S., Vries, M. J. A., Westbury, S. K., Greene, D., Papadia, S., Alessi, M.-C., Attwood, A. P., Ballmaier, M., Baynam, G., Bermejo, E., Bertoli, M., ... Turro, E. (2016). A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood, 127(23), 2791-2803. https://doi.org/10.1182/blood-2015-12-688267