Publications
- 2015
- Loeffen, R., Winckers, K., Ford, I., Jukema, J. W., Robertson, M., Stott, D. J., Spronk, H. M., ten Cate, H., & Lowe, G. D. (2015). Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 70(8), 982-988. https://doi.org/10.1093/gerona/glu228
- Driessen, J. H. M., Henry, R. M. A., van Onzenoort, H. A. W., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G. M., & de Vries, F. (2015). Bone Fracture Risk is Not Associated with the Use of Glucagon-Like Peptide-1 Receptor Agonists: A Population-Based Cohort Analysis. Calcified Tissue International, 97(2), 104-112. https://doi.org/10.1007/s00223-015-9993-5
- Spauwen, P. J. J., van Boxtel, M. P. J., Verhey, F. R. J., Kohler, S., Sep, S. J. S., Koster, A., Dagnelie, P. C., Henry, R. M. A., Schaper, N. C., van der Kallen, C. J. H., Schram, M. T., Kroon, A. A., & Stehouwer, C. D. A. (2015). Both Low and High 24-Hour Diastolic Blood Pressure Are Associated With Worse Cognitive Performance in Type 2 Diabetes: The Maastricht Study. Diabetes Care, 38(8), 1473-1480. https://doi.org/10.2337/dc14-2502
- Swieringa, F., Lance, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Van Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M., & Van der Meijden, P. E. J. (2015). Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding. Journal of Thrombosis and Haemostasis, 13(8), 1503-1513. https://doi.org/10.1111/jth.13007
- Vajen, T., Mause, S. F., & Koenen, R. R. (2015). Microvesicles from platelets: novel drivers of vascular inflammation. Thrombosis and Haemostasis, 114(2), 228-236. https://doi.org/10.1160/TH14-11-0962
- Konings, J., Hoving, L. R., Ariens, R. S., Hethershaw, E. L., Ninivaggi, M., Hardy, L. J., de Laat, B., ten Cate, H., Philippou, H., & Govers-Riemslag, J. W. P. (2015). The role of activated coagulation factor XII in overall clot stability and fibrinolysis. Thrombosis Research, 136(2), 474-480. https://doi.org/10.1016/j.thromres.2015.06.028
- Loeffen, R., Godschalk, T. C., van Oerle, R., Spronk, H. M. H., Hackeng, C. M., ten Berg, J. M., & ten Cate, H. (2015). The hypercoagulable profile of patients with stent thrombosis. Heart, 101(14), 1126-1132. https://doi.org/10.1136/heartjnl-2014-306685
- van Sloten, T. T., Czernichow, S., Houben, A. J., Protogerou, A. D., Henry, R. M., Muris, D. M., Schram, M. T., Sep, S. J., Dagnelie, P. C., van der Kallen, C. J., Schaper, N. C., Blacher, J., Hercberg, S., Levy, B. I., & Stehouwer, C. D. (2015). Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study. American Journal of Hypertension, 28(7), 868-876. https://doi.org/10.1093/ajh/hpu246
- ENGAGE Consortium (2015). Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. Plos Genetics, 11(7), Article e1005230. https://doi.org/10.1371/journal.pgen.1005230
- den Exter, P. L., van Es, J., Kroft, L. J. M., Erkens, P. M. G., Douma, R. A., Mos, I. C. M., Jonkers, G., Hovens, M. M. C., Durian, M. F., ten Cate, H., Beenen, L. F. M., Kamphuisen, P. W., & Huisman, M. V. (2015). Thromboembolic resolution assessed by CT pulmonary angiography after treatment for acute pulmonary embolism. Thrombosis and Haemostasis, 114(1), 26-34. https://doi.org/10.1160/TH14-10-0842
- Spronk, H. M. H., Braunschweig, T., Rossaint, R., Wuest, D. C., van Oerle, R., Lauritzen, B., Tolba, R., & Grottke, O. (2015). Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia. PLOS ONE, 10(6), Article e0113979. https://doi.org/10.1371/journal.pone.0113979
- Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A.-K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J. M., van Leeuwen, E. M., ... Boomsma, D. I. (2015). Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nature Communications, 6, 7208. https://doi.org/10.1038/ncomms8208
- Mastenbroek, T. G., Van Geffen, J. P., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2015). Acute and persistent platelet and coagulant activities in atherothrombosis. Journal of Thrombosis and Haemostasis, 13(S1), S272-S280. https://doi.org/10.1111/jth.12972
- van Sloten, T. T., Protogerou, A. D., Henry, R. M. A., Schram, M. T., Launer, L. J., & Stehouwer, C. D. A. (2015). Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 53, 121-130. https://doi.org/10.1016/j.neubiorev.2015.03.011
- WiN Study Group (2015). CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease. Journal of Thrombosis and Haemostasis, 13(6), 956-66. https://doi.org/10.1111/jth.12927
- Kuijpers, M. J. E., Mattheij, N. J. A., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M. P. C., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M. E. M., Lutgens, E., & Heemskerk, J. W. M. (2015). Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and I kappa B Kinase alpha. Arteriosclerosis Thrombosis and Vascular Biology, 35(6), 1374-1381. https://doi.org/10.1161/ATVBAHA.114.305127
- Swieringa, F., Kuijpers, M. J. E., Lamers, M. M. E., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2015). Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow. Haematologica-the Hematology Journal, 100(6), 748-756. https://doi.org/10.3324/haematol.2014.116863
- Grottke, O., & ten Cate, H. (2015). Reply to Faraoni D, Fenger-Eriksen C, Gillard S et al. Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. Pediatric Anesthesia, 25(6), 646-647. https://doi.org/10.1111/pan.12650
- Surakka, I., Horikoshi, M., Mägi, R., Sarin, A.-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hägg, S., Hottenga, J.-J., Isaacs, A., Ladenvall, C., Beekman, M., ... Ripatti, S. (2015). The impact of low-frequency and rare variants on lipid levels. Nature Genetics, 47(6), 589-97. https://doi.org/10.1038/ng.3300
- Hu, Q., van Gaal, E. V. B., Brundel, P., Ippel, H., Hackeng, T., Rijcken, C. J. F., Storm, G., Hennink, W. E., & Prakash, J. (2015). A novel approach for the intravenous delivery of leuprolide using core-cross-linked polymeric micelles. Journal of Controlled Release, 205, 98-108. https://doi.org/10.1016/j.jconrel.2014.12.023
- Hermanns, M. I., Grossmann, V., Spronk, H. M. H., Schulz, A., Juenger, C., Laubert-Reh, D., Mazur, J., Gori, T., Zeller, T., Pfeiffer, N., Beutel, M., Blankenberg, S., Muenzel, T., Lackner, K. J., Hoek - ten Cate, A. J., ten Cate, H., & Wild, P. S. (2015). Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. International Journal of Cardiology, 187(1), 166-174. https://doi.org/10.1016/j.ijcard.2015.03.330
- van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Zarzycka, B., Beckers, L., den Toom, M., Gijbels, M. J. J., Chatzigeorgiou, A., Weber, C., de Winther, M. P. J., Chavakis, T., Nicolaes, G. A. F., & Lutgens, E. (2015). Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. International Journal of Obesity, 39(5), 782-790. https://doi.org/10.1038/ijo.2014.198
- Geenen, I. L. A., Molin, D. G. M., van den Akker, N. M. S., Jeukens, F., Spronk, H. M., Schurink, G. W. H., & Post, M. J. (2015). Endothelial cells (ECs) for vascular tissue engineering: venous ECs are less thrombogenic than arterial ECs. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 564-576. https://doi.org/10.1002/term.1642
- Knapen, M. H. J., Braam, L. A. J. L. M., Drummen, N. E., Bekers, O., Hoeks, A. P. G., & Vermeer, C. (2015). Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women A double-blind randomised clinical trial. Thrombosis and Haemostasis, 113(5), 1135-1144. https://doi.org/10.1160/TH14-08-0675
- Nagy, R. A., van Montfoort, A. P. A., Dikkers, A., van Echten-Arends, J., Homminga, I., Land, J. A., Hoek - ten Cate, A., & Tietge, U. J. F. (2015). Presence of bile acids in human follicular fluid and their relation with embryo development in modified natural cycle IVF. Human Reproduction, 30(5), 1102-1109. https://doi.org/10.1093/humrep/dev034
- Posthuma, J. J., van der Meijden, P. E. J., ten Cate, H., & Spronk, H. M. H. (2015). Short- and Long-term exercise induced alterations in haemostasis: a review of the literature. Blood Reviews, 29(3), 171-178. https://doi.org/10.1016/j.blre.2014.10.005
- Zarzycka, B., Nicolaes, G. A. F., & Lutgens, E. (2015). Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis. Expert Review of Clinical Pharmacology, 8(3), 297-313. https://doi.org/10.1586/17512433.2015.1025052
- Whyte, C. S., Swieringa, F., Mastenbroek, T. G., Lionikiene, A. S., Lance, M. D., van der Meijden, P. E. J., Heemskerk, J. W. M., & Mutch, N. J. (2015). Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow. Blood, 125(16), 2568-2578. https://doi.org/10.1182/blood-2014-09-599480
- Vries, M. H. M., Wagenaar, A., Verbruggen, S. E. L., Molin, D. G. M., Dijkgraaf, I., Hackeng, T., & Post, M. J. (2015). CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis, 18(2), 163-171. https://doi.org/10.1007/s10456-014-9454-1
- Ippel, H., Miller, M. C., Berbis, M. A., Suylen, D., Andre, S., Hackeng, T. M., Canada, F. J., Weber, C., Gabius, H.-J., Jimenez-Barbero, J., & Mayo, K. H. (2015). H-1, C-13, and N-15 backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3. Biomolecular Nmr Assignments, 9(1), 59-63. https://doi.org/10.1007/s12104-014-9545-3
- Plompen, E. P. C., Hansen, B. E., Schouten, J. N. L., Darwish Murad, S., Loth, D. W., Brouwer, W. P., Isaacs, A., Taimr, P., Hofman, A., van Duijn, C. M., Uitterlinden, A. G., Stricker, B. H. C., Leebeek, F. W. G., & Janssen, H. L. A. (2015). Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study. Gut, 64(4), 692-4. https://doi.org/10.1136/gutjnl-2014-308398
- Kicken, C., Van Poucke, S., Marcus, A. E., Lance, M. D., & Henskens, Y. (2015). Response of platelet concentrates to pressure and temperature changes without impairment of the in vitro function. Thrombosis Research, 135(4), 679-683. https://doi.org/10.1016/j.thromres.2015.01.004
- Strijkers, R. H. W., de Wolf, M. A. F., Arnoldussen, C. W. K. P., Timbergen, M. J. M., de Graaf, R., Hoek - ten Cate, A. J., & Wittens, C. H. A. (2015). Venous In-stent Thrombosis Treated by Ultrasound Accelerated Catheter Directed Thrombolysis. European Journal of Vascular and Endovascular Surgery, 49(4), 440-447. https://doi.org/10.1016/j.ejvs.2015.01.006
- Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., Luan, J., Kutalik, Z., Sanna, S., van der Meer, P., Tanaka, T., Wang, F., Westra, H.-J., Franke, L., Mihailov, E., ... Whitfield, J. B. (2015). Correction: Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications, 6, 6542. https://doi.org/10.1038/ncomms7542
- van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D. J., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., ... van Duijn, C. (2015). Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nature Communications, 6, 6065. https://doi.org/10.1038/ncomms7065
- van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015). A Healthy Diet is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease. Journal of Nutrition, 145(3), 532-540. https://doi.org/10.3945/jn.114.201236
- Nuzzo, F., Bulato, C., Nielsen, B. I., Lee, K., Wielders, S. J., Simioni, P., Key, N. S., & Castoldi, E. (2015). Characterization of an apparently synonymous F5 mutation causing aberrant splicing and factor V deficiency. Haemophilia, 21(2), 241-248. https://doi.org/10.1111/hae.12554
- GARFIELD-AF Investigators, & ten Cate, H. (2015). Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation. Circulation : Cardiovascular Quality and Outcomes, 8(2), S12-S20. https://doi.org/10.1161/CIRCOUTCOMES.114.001556
- van Geffen, J. P., Kleinegris, M.-C., Verdoold, R., Baaten, C. C. F. M. J., Cosemans, J. M. E. M., Clemetson, K. J., ten Cate, H., Roest, M., de Laat, B., & Heemskerk, J. W. M. (2015). Normal Platelet Activation Profile in Patients with Peripheral Arterial Disease on Aspirin. Thrombosis Research, 135(3), 513-520. https://doi.org/10.1016/j.thromres.2014.12.029
- Eijgenraam, P., Meertens, N., van den Ham, R., ten Cate, H., & Hoek - ten Cate, A. (2015). The effect of clinical decision support on adherence to thrombosis prophylaxis guidelines in medical patients; A single center experience. Thrombosis Research, 135(3), 464-471. https://doi.org/10.1016/j.thromres.2014.12.012
- Dargaud, Y., Scoazec, J. Y., Wielders, S. J. H., Trzeciak, C., Hackeng, T. M., Negrier, C., Hemker, H. C., Lindhout, T., & Castoldi, E. (2015). Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation. Blood, 125(9), 1497-1501. https://doi.org/10.1182/blood-2014-10-604553
- van Bussel, F. C. G., van Bussel, B. C. T., Hoeks, A. P. G., op 't Roodt, J., Henry, R. M. A., Ferreira, I., Vanmolkot, F. H. M., Schalkwijk, C. G., Stehouwer, C. D. A., & Reesink, K. D. (2015). A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery. PLOS ONE, 10(2), Article e0115977. https://doi.org/10.1371/journal.pone.0115977
- Musumeci, L., Kuijpers, M. J., Gilio, K., Hego, A., Theatre, E., Maurissen, L., Vandereyken, M., Diogo, C. V., Lecut, C., Guilmain, W., Bobkova, E. V., Eble, J. A., Dahl, R., Drion, P., Rascon, J., Mostofi, Y., Yuan, H., Sergienko, E., Chung, T. D. Y., ... Rahmouni, S. (2015). Dual-Specificity Phosphatase 3 Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis. Circulation, 131(7), 656-U194. https://doi.org/10.1161/CIRCULATIONAHA.114.010186
- Karshovska, E., Zhao, Z., Blanchet, X., Schmitt, M. M. N., Bidzhekov, K., Soehnlein, O., von Hundelshausen, P., Mattheij, N. J., Cosemans, J. M. E. M., Megens, R. T. A., Koeppel, T. A., Schober, A., Hackeng, T. M., Weber, C., & Koenen, R. R. (2015). Hyperreactivity of Junctional Adhesion Molecule A-Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice. Circulation Research, 116(4), 587-599. https://doi.org/10.1161/CIRCRESAHA.116.304035
- Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J. C., ... Speliotes, E. K. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. https://doi.org/10.1038/nature14177
- Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., Strawbridge, R. J., Pers, T. H., Fischer, K., Justice, A. E., Workalemahu, T., Wu, J. M. W., Buchkovich, M. L., Heard-Costa, N. L., Roman, T. S., Drong, A. W., Song, C., Gustafsson, S., Day, F. R., ... Mohlke, K. L. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. https://doi.org/10.1038/nature14132
- Zarzycka, B., Seijkens, T., Nabuurs, S. B., Ritschel, T., Grommes, J., Soehnlein, O., Schrijver, R., van Tiel, C. M., Hackeng, T. M., Weber, C., Giehler, F., Kieser, A., Lutgens, E., Vriend, G., & Nicolaes, G. A. F. (2015). Discovery of Small Molecule CD40-TRAF6 Inhibitors. Journal of Chemical Information and Modeling, 55(2), 294-307. https://doi.org/10.1021/ci500631e
- Jainandunsing, S., Özcan, B., Rietveld, T., van Miert, J. N. I., Isaacs, A. J., Langendonk, J. G., de Rooij, F. W. M., & Sijbrands, E. J. G. (2015). Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes. Acta Diabetologica, 52(1), 11-9. https://doi.org/10.1007/s00592-014-0588-9
- Du, J., Wichapong, K., Hackeng, T. M., & Nicolaes, G. A. F. (2015). Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding. Thrombosis and Haemostasis, 113(2), 373-384. https://doi.org/10.1160/TH14-02-0180