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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2024
    • Velt, M. J. H., Crijns, H. J. G. M., van Gelder, I. C., Linz, D., van de Lande, M. E., Ten Cate, H., Spronk, H. M. H., de Melis, M., Rienstra, M., & Mulder, B. A. (2024). Dynamic biomarker profiles in patients with paroxysmal atrial fibrillation: Assessing the differences between sinus rhythm and acute atrial fibrillation episode. International Journal of Cardiology, 417, Article 132526. https://doi.org/10.1016/j.ijcard.2024.132526
    • Mourmans, S. G. J., Weerts, J., Baumert, M., Aizpurua, A. B., Achten, A., Knackstedt, C., Linz, D., & van Empel, V. P. M. (2024). Prognostic value of hypoxaemic burden from overnight oximetry in heart failure with preserved ejection fraction. Esc heart failure. Advance online publication. https://doi.org/10.1002/ehf2.15116
    • Gawalko, M., Middeldorp, M. E., Saljic, A., Penders, J., Jespersen, T., Albert, C. M., Marcus, G. M., Wong, C. X., Sanders, P., & Linz, D. (2024). Diet and risk of atrial fibrillation: a systematic review. European Heart Journal, 45(40), 4259-4274. Article ehae551. https://doi.org/10.1093/eurheartj/ehae551
    • Joza, J., Burri, H., Andrade, J. G., Linz, D., Ellenbogen, K. A., & Vernooy, K. (2024). Atrioventricular node ablation for atrial fibrillation in the era of conduction system pacing. European Heart Journal, Article ehae656. https://doi.org/10.1093/eurheartj/ehae656
    • Gottlieb, L. A., Mahfoud, F., Stavrakis, S., Jespersen, T., & Linz, D. (2024). Autonomic Nervous System: A Therapeutic Target for Cardiac End-Organ Damage in Hypertension. Hypertension, 81(10), 2027-2037. Article 19460. https://doi.org/10.1161/HYPERTENSIONAHA.123.19460
    • Chaldoupi, S.-M., Nissen, S. D., Vriesendorp, P. A., Jerltorp, K., Farnir, F. I. P., Linz, B., Johannessen, A., Haugdal, M. A., Luermans, J. G. L. M., Saljic, A., Jespersen, T., Hansen, J., & Linz, D. (2024). Focal monopolar pulsed field ablation from within the great cardiac vein for idiopathic premature ventricular contractions after failed radiofrequency ablation. Heart Rhythm, 21(10), 1877-1887. https://doi.org/10.1016/j.hrthm.2024.07.002
    • Bijvoet, G. P., Hermans, B. J. M., Linz, D., Luermans, J. G. L. M., Maesen, B., Nijveldt, R., Mihl, C., Vernooy, K., Wildberger, J. E., Holtackers, R. J., Schotten, U., & Chaldoupi, S.-M. (2024). Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR. JACC: Clinical Electrophysiology, 10(10), 2186-2197. https://doi.org/10.1016/j.jacep.2024.05.017
    • Sandgren, E., Hermans, A. N., Gawalko, M., Betz, K., Sohaib, A., Fung, C. H., Hillmann, H. A., van der Velden, R. M., Verhaert, D., Scherr, D., Sultan, A., Steven, D., Pisters, R., Hemels, M., Lodzinski, P., Chaldoupi, S.-M., Gupta, D., Gruwez, H., Pluymaekers, N. A., ... TeleCheck-AF investigators (2024). Smartphone app-based approximation of time spent with atrial fibrillation and symptoms in patients after catheter ablation: Data from the TeleCheck-AF project. EP Europace, 26(10), Article euae247. https://doi.org/10.1093/europace/euae247
    • Rijks, J. H. J., Heckman, L., Westra, S., Cornelussen, R., Ghosh, S., Curila, K., Smisek, R., Grieco, D., Bressi, E., Nguyen, U. C., Lumens, J., van Stipdonk, A. M. W., Linz, D., Prinzen, F. W., Luermans, J. G. L. M., & Vernooy, K. (2024). Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods. Journal of Cardiovascular Electrophysiology, Article 16435. https://doi.org/10.1111/jce.16435
    • Malik, V., Linz, D., & Sanders, P. (2024). The Role of the Autonomic Nervous System as Both “Trigger and “Substrate” in Atrial Fibrillation. Cardiac Electrophysiology Clinics, 16(3), 271-280. https://doi.org/10.1016/j.ccep.2023.08.003
    • Shahrbabaki, S. S., Dharmaprani, D., Tiver, K. D., Jenkins, E., Strong, C., Tonchev, I., O'Loughlin, L. P., Linz, D., Chapman, D., Lechat, B., Ullah, S., Stone, K. L., Eckert, D. J., Baumert, M., & Ganesan, A. N. (2024). Power-law properties of nocturnal arrhythmia avalanches: a novel marker for incident cardiovascular events. Heart Rhythm. Advance online publication. https://doi.org/10.1016/j.hrthm.2024.08.015
    • Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., & Schotten, U. (2024). Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery. Heart Rhythm. Advance online publication. https://doi.org/10.1016/j.hrthm.2024.08.014
    • Linz, D., & Dobrev, D. (2024). Recent highlights from the International Journal of Cardiology heart & Vasculature: Comprehensive management of atrial fibrillation. IJC Heart and Vasculature, 53, Article 101478. https://doi.org/10.1016/j.ijcha.2024.101478
    • Linz, D., & Hermans, B. J. M. (2024). Remote technical support of nurse-lead electro-anatomic mapping during complex catheter ablation procedures. European Journal of Cardiovascular Nursing. Advance online publication. https://doi.org/10.1093/eurjcn/zvae108
    • Linz, D., & Chaldoupi, S. M. (2024). Early Rhythm Management in Patients With Atrial Fibrillation: From Symptom Control to Adverse Outcome Reduction. JACC: Clinical Electrophysiology, 10(7), 1406-1408. https://doi.org/10.1016/j.jacep.2024.06.003
    • Calvert, P., Mills, M. T., Howarth, K., Aykara, S., Lunt, L., Brewer, H., Green, D., Green, J., Moore, S., Almutawa, J., Linz, D., Lip, G. Y. H., Todd, D., & Gupta, D. (2024). Remote rhythm monitoring using a photoplethysmography smartphone application after cardioversion for atrial fibrillation. European Heart Journal - Digital Health, 5(4), 461-468. Article ztae028. https://doi.org/10.1093/ehjdh/ztae028
    • Ekanem, E., Neuzil, P., Reichlin, T., Kautzner, J., van der Voort, P., Jais, P., Chierchia, G. B., Bulava, A., Blaauw, Y., Skala, T., Fiala, M., Duytschaever, M., Szeplaki, G., Schmidt, B., Massoullie, G., Neven, K., Thomas, O., Vijgen, J., Gandjbakhch, E., ... Et al. (2024). Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nature Medicine, 30(7), 2020-2029. https://doi.org/10.1038/s41591-024-03114-3
    • Wörmann, J., Strik, M., Jurisic, S., Stout, K., Elrefai, M., Becher, N., Schaer, B., van Stipdonk, A., Srinivasan, N. T., Ploux, S., Breitenstein, A., Kron, J., Roberts, P. R., Toennis, T., Linz, D., Dulai, R., Hermes-Laufer, J., Koneru, J., Erküner, Ö., ... Lüker, J. (2024). Occurrence of Premature Battery Depletion in a Large Multicenter Registry of Subcutaneous Cardioverter-Defibrillator Patients. EP Europace, 26(7), Article euae170. https://doi.org/10.1093/europace/euae170
    • Wörmann, J., Strik, M., Jurisic, S., Stout, K., Elrefai, M., Becher, N., Schaer, B., van Stipdonk, A., Srinivasan, N. T., Ploux, S., Breitenstein, A., Kron, J., Roberts, P. R., Toennis, T., Linz, D., Dulai, R., Hermes-Laufer, J., Koneru, J., Erküner, Ö., ... Lüker, J. (2024). Incidence, Implications, and Management of Sense-B-Noise Failure in Subcutaneous Cardioverter-Defibrillator Patients: insights from a large Multicenter Registry. EP Europace, 26(6), Article euae161. https://doi.org/10.1093/europace/euae161
    • Norup Hertel, J., Isaksen, J. L., Jerltorp, K., Dalgas Nissen, S., Hansen, M., Saljic, A., Linz, B., Sattler, S., Ye, C., Overgaard Larsen, J., Nørregaard, M., Chaldoupi, S.-M., Gang, U., Manninger, M., Jespersen, T., & Linz, D. (2024). Catheter-based pulmonary vein isolation fails to prevent transient atrial arrhythmogenic changes related to acute obstructive respiratory events in a porcine model. EP Europace, 26(6), Article euae132. https://doi.org/10.1093/europace/euae132
    • Frausing, M. H. J. P., van de Lande, M., Linz, D., Crijns, H. J. G. M., Tieleman, R. G., Hemels, M. E. W., De Melis, M., Schotten, U., Kronborg, M. B., Nielsen, J. C., Van Gelder, I., & Rienstra, M. (2024). Healthcare utilisation and quality of life according to atrial fibrillation burden, episode frequency and duration. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2024-324016
    • Guenzler, V., Arzt, M., Grimm, M., Ebert, A., Zeman, F., Linz, D., Woehrle, H., Tamisier, R., Cowie, M., & Fisser, C. (2024). Temporal association of ventricular arrhythmias and respiratory events in heart failure patients with central sleep apnoea. Sleep Medicine, 118, 59-62. https://doi.org/10.1016/j.sleep.2024.04.002
    • Betz, K., Linz, D., Duncker, D., & Hillmann, H. A. K. (2024). Charakterisierung der Vorhofflimmerlast mittels Wearables. Herzschrittmachertherapie und Elektrophysiologie, 35(2), 111-117. https://doi.org/10.1007/s00399-024-00995-2
    • Duncker, D., & Linz, D. (2024). eCardiology in der Rhythmologie. Herzschrittmachertherapie und Elektrophysiologie, 35(2), 95-96. https://doi.org/10.1007/s00399-024-01024-y
    • van der Velden, R. M. J., Bonander, C., Crijns, H. J. G. M., Kemp-Gudmundsdottir, K., Engdahl, J., Linz, D., & Svennberg, E. (2024). Adherence to a handheld device-based atrial fibrillation screening protocol is associated with clinical outcomes. Heart, 110(9), 626-634. https://doi.org/10.1136/heartjnl-2023-323522
    • Aydeniz, E., Weberndorfer, V., Brandts, L., Smulders, M. W., van Herpt, T. T. W., Martens, B., Vernooy, K., Linz, D., van der Horst, I. C. C., Wildberger, J. E., van Bussel, B. C. T., Driessen, R. G. H., & Mihl, C. (2024). Pericardial Fat Is Associated With Less Severe Multiorgan Failure Over Time in Patients With Coronavirus Disease-19: The Maastricht Intensive Care COVID Cohort. Journal of Thoracic Imaging, 39(3), W32-W39. https://doi.org/10.1097/RTI.0000000000000732
    • Bijvoet, G. P., Nies, H. M. J. M., Holtackers, R. J., Martens, B. M., Smink, J., Linz, D., Vernooy, K., Wildberger, J. E., Nijveldt, R., Chaldoupi, S. M., & Mihl, C. (2024). Tissue characterization of acute lesions during cardiac magnetic resonance-guided ablation of cavo-tricuspid isthmus-dependent atrial flutter: a feasibility study. European Heart Journal Cardiovascular Imaging, 25(5), 635-644. Article jead334. https://doi.org/10.1093/ehjci/jead334
    • Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., & Schotten, U. (2024). Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery: Prospective RACE V Cohort. JACC: Clinical Electrophysiology, 10(5), 941-955. https://doi.org/10.1016/j.jacep.2024.01.013
    • Hertel, J. N., Linz, B., Isaksen, J., Jerltorp, K., Leonhardt, C., Gottlieb, L., Saljic, A., Jespersen, T., & Linz, D. (2024). Inhibition of the acetylcholine-regulated potassium current prevents transient apnea-related atrial arrhythmogenic changes in a porcine model. Heart Rhythm, 21(5), 622-629. https://doi.org/10.1016/j.hrthm.2024.01.033
    • Steffens, S., Schröder, K., Krüger, M., Maack, C., Streckfuss-Bömeke, K., Backs, J., Backofen, R., Baeßler, B., Devaux, Y., Gilsbach, R., Heijman, J., Knaus, J., Kramann, R., Linz, D., Lister, A. L., Maatz, H., Maegdefessel, L., Mayr, M., Meder, B., ... Kohl, P. (2024). The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clinical research in cardiology, 113(5), 672-679. https://doi.org/10.1007/s00392-023-02303-3
    • Linz, D., Andrade, J. G., Arbelo, E., Boriani, G., Breithardt, G., Camm, A. J., Caso, V., Nielsen, J. C., De Melis, M., De Potter, T., Dichtl, W., Diederichsen, S. Z., Dobrev, D., Doll, N., Duncker, D., Dworatzek, E., Eckardt, L., Eisert, C., Fabritz, L., ... Kirchhof, P. (2024). Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference. EP Europace, 26(4), Article euae070. https://doi.org/10.1093/europace/euae070
    • Kjeldsen, S. T., Nissen, S. D., Saljic, A., Hesselkilde, E. M., Carstensen, H., Sattler, S. M., Jespersen, T., Linz, D., Hopster-Iversen, C., Kutieleh, R., Sanders, P., & Buhl, R. (2024). Structural and electro-anatomical characterization of the equine pulmonary veins: implications for atrial fibrillation. Journal of Veterinary Cardiology, 52, 1-13. https://doi.org/10.1016/j.jvc.2024.01.001
    • Farnir, F., Chaldoupi, S.-M., Farnir, F., Schotten, U., Vernooy, K., Luermans, J., & Linz, D. (2024). Focal point-by-point biphasic monopolar pulsed field ablation for posterior wall isolation. EP Europace, 26(4), Article euae077. https://doi.org/10.1093/europace/euae077
    • Hermans, B., Özgül, O., Wolf, M., Gonçalves Marques, V., van Hunnik, A., Verheule, S., Chaldoupi, M., Linz, D., El Haddad, M., Duytschaever, M., Bonizzi, P., Vernooy, K., Knecht, S., Zeemering, S., & Schotten, U. (2024). Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation. Journal of Molecular and Cellular Cardiology Plus, 7, Article 100064. https://doi.org/10.1016/j.jmccpl.2024.100064
    • Gawalko, M., Betz, K., Hendriks, V., Hermans, A. N. L., van der Velden, R. M. J., Manninger, M., Chaldoupi, S.-M., Hoogervorst, H., Martens, H., Pluymaekers, N. A. H. A., Spreeuwenberg, M. D., Hendriks, J., & Linz, D. (2024). Changes in healthcare utilisation during implementation of remote atrial fibrillation management: TeleCheck-AF project. Netherlands Heart Journal, 32(3), 130-139. https://doi.org/10.1007/s12471-023-01836-6
    • Duncker, D., Billig, H., Frey, N., Geiß, E., Johnson, V., Linz, D., Manteufel, S., Meder, B., Messiha, D., Perings, C. A., Rassaf, T., Sommer, P., Thiele, H., & Breitbart, P. (2024). Professioneller Umgang mit sozialen Medien in der Kardiologie: Positionspapier der Deutschen Gesellschaft für Kardiologie. Die Kardiologie, 18(2), 176-186. https://doi.org/10.1007/s12181-024-00665-0
    • Nies, H. M. J. M., Bijvoet, G. P., Smink, J., Chaldoupi, S.-M., Mihl, C., Linz, D., & Holtackers, R. J. (2024). A comprehensive guide on real-time catheter localization techniques in magnetic resonance imaging-guided ablation therapy for cardiac arrhythmias. European Heart Journal Cardiovascular Imaging, 25(2), 149-151. https://doi.org/10.1093/ehjci/jead325
    • Linz, D., Gawalko, M., Betz, K., Hendriks, J. M., Lip, G. Y. H., Vinter, N., Guo, Y., & Johnsen, S. (2024). Atrial fibrillation: epidemiology, screening and digital health. The Lancet Regional Health – Europe, 37, Article 100786. https://doi.org/10.1016/j.lanepe.2023.100786
    • Betz, K., Giordano, M., Hillmann, H. A. K., Duncker, D., Dobrev, D., & Linz, D. (2024). The impact of Twitter/X promotion on visibility of research articles: Results of the #TweetTheJournal study. IJC Heart and Vasculature, 50, Article 101328. https://doi.org/10.1016/j.ijcha.2023.101328
    • Verhaert, D. V. M., Linz, D., & Maesen, B. (2024). Redo cardiac surgery and atrial fibrillation: the ablation dilemma. Journal of Thoracic Disease, 16(1), 8-11. https://doi.org/10.21037/jtd-23-1741
    • Betz, K., Van Haren, J., Duncker, D., Manninger, M., Lemmink, J., & Linz, D. (2024). Network analysis of the social media activities around the #TeleCheckAF project. European Heart Journal - Digital Health, 5(1), 97-100. https://doi.org/10.1093/ehjdh/ztad066
    • Farnir, F. I. P., Luermans, J. G. L. M., Farnir, F. P. F. J. D. J., Chaldoupi, S. M., & Linz, D. (2024). Impedance drop during focal monopolar pulsed field ablation in the atrium. Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-024-01793-z
    • Nies, H. M. J. M., Linz, D., Bijvoet, G. P., Holtackers, R. J., Luermans, J. G. L. M., van der Velden, K. E. H. M., Wildberger, J. E., Vernooy, K., van Kuijk, S. M. J., Mihl, C., & Chaldoupi, S. M. (2024). Local atrial bipolar electrogram voltage drops during cardiac magnetic resonance guided catheter ablation of typical atrial flutter: Associations with delivered radiofrequency energy and peri-procedural imaging. Heart Rhythm O2. Advance online publication. https://doi.org/10.1016/j.hroo.2024.08.015
    • van der Velden, R. M. J., Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Luermans, J. G. L. M., Meeder, J. G., Heesen, W. F., Lenderink, T., Widdershoven, J. W. M. G., Bucx, J. J. J., Rienstra, M., Kamp, O., van Opstal, J. M., Kirchhof, C. J. H. J., van Dijk, V. F., Swart, H. P., Alings, M., Van Gelder, I. C., Crijns, H. J. G. M., & Linz, D. (2024). Cardioversion strategy impacts rate control during recurrences in patients with paroxysmal atrial fibrillation: A subanalysis of the RACE 7 ACWAS trial. Clinical Cardiology, 47(1), Article e24161. https://doi.org/10.1002/clc.24161
    • Farnir, F., Luermans, J., Manusama, R., den Uijl, D., Chaldoupi, S. M., & Linz, D. (2024). Focal point-by-point pulsed field ablation for the treatment of atrial arrhythmias in patients with challenging anatomy where radiofrequency ablation cannot be applied: A case series. HeartRhythm Case Reports, 10(1), 21-25. https://doi.org/10.1016/j.hrcr.2023.10.012
    • Linz, D., & Chaldoupi, S.-M. (2024). Longitudinal mapping of the bidirectional relationship between atrial fibrillation and cardiac remodeling. Heart Rhythm, 21(1), 16-17. https://doi.org/10.1016/j.hrthm.2023.10.018
    • Hartmann, S., Immanuel, S., McKane, S., Linz, D., Parrino, L., & Baumert, M. (2024). Transvenous phrenic nerve stimulation for treating central sleep apnea may regulate sleep microstructure. Sleep Medicine, 113(1), 70-75. https://doi.org/10.1016/j.sleep.2023.11.005
    • Polman, R., Hurst, J. R., Uysal, O. F., Mandal, S., Linz, D., & Simons, S. (2024). Cardiovascular disease and risk in COPD: a state of the art review. Expert review of cardiovascular therapy, 22(4-5), 177-191. https://doi.org/10.1080/14779072.2024.2333786
  • 2023
    • Mulder, B. A., Khalilian Ekrami, N., Van De Lande, M. E., Nguyen, B.-O., Weberndorfer, V., Crijns, H. J., Geelhoed, B., Blaauw, Y., Hemels, M. E., Tieleman, R. G., Scheerder, C. O., De Melis, M., Schotten, U., Linz, D., Van Gelder, I. C., & Rienstra, M. (2023). Women have less progression of paroxysmal atrial fibrillation: data from the RACE V study. Open Heart, 10(2), Article e002534. https://doi.org/10.1136/openhrt-2023-002534
    • Hermans, B. J. M., Bijvoet, G. P., Holtackers, R. J., Mihl, C., Luermans, J. G. L. M., Maesen, B., Vernooy, K., Linz, D., Chaldoupi, S. M., & Schotten, U. (2023). Multi-modal characterization of the left atrium by a fully automated integration of pre-procedural cardiac imaging and electro-anatomical mapping. IJC Heart and Vasculature, 49(1), Article 101276. https://doi.org/10.1016/j.ijcha.2023.101276
Overview