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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Frits Prinzen

Professor

Frits Prinzen is emeritus professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 330 scientific articles, with >10,000 citations and H-index of 56.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Frits-prinzen
Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2024
    • Beela, A. S., Manetti, C. A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2024). The mechanistic interaction between mechanical dyssynchrony and filling pressure in cardiac resynchronization therapy candidates. European Heart Journal Cardiovascular Imaging, Article jeae286. Advance online publication. https://doi.org/10.1093/ehjci/jeae286
    • van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal. Advance online publication. https://doi.org/10.1093/eurheartj/ehae718
    • Rijks, J. H. J., Heckman, L., Westra, S., Cornelussen, R., Ghosh, S., Curila, K., Smisek, R., Grieco, D., Bressi, E., Nguyen, U. C., Lumens, J., van Stipdonk, A. M. W., Linz, D., Prinzen, F. W., Luermans, J. G. L. M., & Vernooy, K. (2024). Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods. Journal of Cardiovascular Electrophysiology, Article 16435. https://doi.org/10.1111/jce.16435
    • Beela, A. S., Rijks, J. H. J., Manetti, C. A., Vernooy, K., van Stipdonk, A. M. W., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2024). Left bundle branch block criteria in the 2021 ESC guidelines on CRT: A step back in identifying CRT candidates?European Heart Journal Cardiovascular Imaging, 25(9), e213-e215. https://doi.org/10.1093/ehjci/jeae164
    • Ghossein, M. A., de Kok, J. W. T. M., Eerenberg, F., van Rosmalen, F., Boereboom, R., Duisberg, F., Verharen, K., Sels, J. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., Meex, S. J. R., van Kuijk, S. M. J., van Stipdonk, A. M. W., Ghossein, C., Prinzen, F. W., van der Horst, I. C. C., Vernooy, K., van Bussel, B. C. T., & Driessen, R. G. H. (2024). Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort. Annals of Noninvasive Electrocardiology, 29(5), Article e70001. https://doi.org/10.1111/anec.70001
    • Brandt, Y., Lubrecht, J. M., Adriaans, B. P., Aben, J.-P., Gerretsen, S. C., Ghossein-Doha, C., Spaanderman, M. E. A., Prinzen, F. W., & Kooi, M. E. (2024). Quantification of left ventricular myocardial strain: Comparison between MRI tagging, MRI feature tracking, and ultrasound speckle tracking. NMR in Biomedicine, 37(9), Article e5164. https://doi.org/10.1002/nbm.5164
    • Bressi, E., Sedlacek, K., Curila, K., Cano, O., Luermans, J. G. L. M., Rijks, J. H. J., Meiburg, R., Smits, K. C., Nguyen, U. C., De Ruvo, E., Calo, L., Kron, J., Ellenbogen, K. A., Prinzen, F., Vernooy, K., & Grieco, D. (2024). Clinical impact and predictors of periprocedural myocardial injury among patients undergoing left bundle branch area pacing. Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-024-01863-2
    • Aydeniz, E., van Rosmalen, F., de Kok, J., Martens, B., Mingels, A. M. A., Canakci, M. E., Mihl, C., Vernooy, K., Prinzen, F. W., Wildberger, J. E., van der Horst, I. C. C., van Bussel, B. C. T., & Driessen, R. G. H. (2024). The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort. Intensive Care Medicine Experimental, 12(1), Article 26. https://doi.org/10.1186/s40635-024-00611-0
    • Leinveber, P., Halamek, J., Curila, K., Prinzen, F., Lipoldova, J., Matejkova, M., Smisek, R., Plesinger, F., Nagy, A., Novak, M., Viscor, I., Vondra, V., & Jurak, P. (2024). Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern. Scientific Reports, 14(1), Article 5681. https://doi.org/10.1038/s41598-024-55789-w
    • Nguyên, U. C., Vernooy, K., & Prinzen, F. W. (2024). Quest for the ideal assessment of electrical ventricular dyssynchrony in cardiac resynchronization therapy. Journal of Molecular and Cellular Cardiology Plus, 7, Article 100061. https://doi.org/10.1016/j.jmccpl.2024.100061
    • Nguyên, U. C., Rijks, J. H. J., Plesinger, F., Rademakers, L. M., Luermans, J., Smits, K. C., van Stipdonk, A. M. W., Prinzen, F. W., Vernooy, K., Halamek, J., Curila, K., & Jurak, P. (2024). Ultra-High-Frequency ECG in Cardiac Pacing and Cardiac Resynchronization Therapy: From Technical Concept to Clinical Application. Journal of Cardiovascular Development and Disease, 11(3), Article 76. https://doi.org/10.3390/jcdd11030076
    • Nguyên, U. C., Prinzen, F. W., & Vernooy, K. (2024). Left ventricular lead placement in cardiac resynchronization therapy: Current data and potential explanations for the lack of benefit. Heart Rhythm, 21(2), 197-205. https://doi.org/10.1016/j.hrthm.2023.10.003
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
    • Dural, M., Ghossein, M. A., Gerrits, W., Daniels, F., Meine, M., Maass, A. H., Rienstra, M., Prinzen, F. W., Vernooy, K., & van Stipdonk, A. M. W. (2024). Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy. EP Europace, 26(1), Article euad370. https://doi.org/10.1093/europace/euad370
  • 2023
    • Wouters, P. C., Zweerink, A., van Everdingen, W. M., Ghossein, M. A., de Roest, G. J., Cramer, M. J., Doevendans, P. A. F. M., Vernooy, K., Prinzen, F. W., Allaart, C. P., & Meine, M. (2023). Prognostic implications of invasive hemodynamics during cardiac resynchronization therapy: stroke work outperforms dP/dt<inf>max</inf>Heart Rhythm O2, 4(12), 777-783. https://doi.org/10.1016/j.hroo.2023.11.003
    • Westphal, P., Luo, H., Shahmohammadi, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2023). Machine learning–powered, device-embedded heart sound measurement can optimize AV delay in patients with CRT. Heart Rhythm, 20(9), 1316-1324. https://doi.org/10.1016/j.hrthm.2023.05.025
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499. https://doi.org/10.1152/japplphysiol.00181.2023
    • Ellenbogen, K. A., Auricchio, A., Burri, H., Gold, M. R., Leclercq, C., Leyva, F., Linde, C., Jastrzebski, M., Prinzen, F., & Vernooy, K. (2023). The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal. EP Europace, 25(8), 1-16. Article euad168. https://doi.org/10.1093/europace/euad168
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908. https://doi.org/10.3390/jcm12154908
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144. https://doi.org/10.1093/europace/euad144
    • Petras, A., Gsell, M. A. F., Augustin, C. M., Rodriguez-Padilla, J., Jung, A., Strocchi, M., Prinzen, F. W., Niederer, S. A., Plank, G., & Vigmond, E. J. (2023). Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology. Computers in Biology and Medicine, 156(1), Article 106696. https://doi.org/10.1016/j.compbiomed.2023.106696
    • Rijks, J., Ghossein, M. A., Wouters, P. C., Dural, M., Maass, A. H., Meine, M., Kloosterman, M., Luermans, J., Prinzen, F. W., Vernooy, K., & van Stipdonk, A. M. W. (2023). Comparison of the relation of the ESC 2021 and ESC 2013 definitions of left bundle branch block with clinical and echocardiographic outcome in cardiac resynchronization therapy. Journal of Cardiovascular Electrophysiology, 34(4), 1006-1014. https://doi.org/10.1111/jce.15882
    • Luo, H., Westphal, P., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Cornelussen, R. N., Delhaas, T., & Prinzen, F. W. (2023). Heart sound-derived systolic time intervals for atrioventricular delay optimization in cardiac resynchronization therapy. Heart Rhythm, 20(4), 572-579. https://doi.org/10.1016/j.hrthm.2022.12.031
    • Kircanski, B., Boveda, S., Prinzen, F., Sorgente, A., Anic, A., Conte, G., & Burri, H. (2023). Corrigendum: Conduction system pacing in everyday clinical practice: EHRA physician survey. EP Europace, 25(3), 1199-1199. Article euad037. https://doi.org/10.1093/europace/euad037
    • Curila, K., Jurak, P., Prinzen, F., Jastrzebski, M., Waldauf, P., Halamek, J., Tothova, M., Znojilova, L., Smisek, R., Kach, J., Poviser, L., Linkova, H., Plesinger, F., Moskal, P., Viscor, I., Vondra, V., Leinveber, P., & Osmancik, P. (2023). Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing. Frontiers in Cardiovascular Medicine, 10(1), Article 1140988. https://doi.org/10.3389/fcvm.2023.1140988
    • Wouters, P. C., van de Leur, R. R., Vessies, M. B., van Stipdonk, A. M. W., Ghossein, M. A., Hassink, R. J., Doevendans, P. A., van der Harst, P., Maass, A. H., Prinzen, F. W., Vernooy, K., Meine, M., & van Es, R. (2023). Electrocardiogram-based deep learning improves outcome prediction following cardiac resynchronization therapy. European Heart Journal, 44(8), 680–692. https://doi.org/10.1093/eurheartj/ehac617
    • Nies, H. M. J. M., Gommers, S., Bijvoet, G. P., Heckman, L. I. B., Prinzen, F. W., Vogel, G., Van de Heyning, C. M., Chiribiri, A., Wildberger, J. E., Mihl, C., & Holtackers, R. J. (2023). Histopathological validation of semi-automated myocardial scar quantification techniques for dark-blood late gadolinium enhancement magnetic resonance imaging. European Heart Journal Cardiovascular Imaging, 24(3), 364-372. https://doi.org/10.1093/ehjci/jeac107
    • Kircanski, B., Boveda, S., Prinzen, F., Sorgente, A., Anic, A., Conte, G., & Burri, H. (2023). Conduction system pacing in everyday clinical practice: EHRA physician survey. EP Europace, 25(2), 682-687. https://doi.org/10.1093/europace/euac201
    • Maffessanti, F., Jadczyk, T., Wilczek, J., Conte, G., Caputo, M. L., Biernat, J., Cybulska, M., Caluori, G., Regoli, F., Krause, R., Wojakowski, W., Prinzen, F. W., Auricchio, A., & Golba, K. S. (2023). Electromechanical factors associated with favourable outcome in cardiac resynchronization therapy. EP Europace, 25(2), 546-553. https://doi.org/10.1093/europace/euac157
    • Luo, H., Weerts, J., Bekkers, A., Achten, A., Lievens, S., Smeets, K., van Empel, V., Delhaas, T., & Prinzen, F. W. (2023). Association between phonocardiography and echocardiography in heart failure patients with preserved ejection fraction. European Heart Journal - Digital Health, 4(1), 4-11. https://doi.org/10.1093/ehjdh/ztac073
    • Prinzen, F. W., Lumens, J., Duchenne, J., & Vernooy, K. (2023). Erratum to: Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 12, Article e19. https://doi.org/10.15420/aer.2023.12.er1
    • van Nieuwenhoven, F. A., Schroen, B., Barile, L., van Middendorp, L., Prinzen, F. W., & Auricchio, A. (2023). Plasma Extracellular Vesicles as Liquid Biopsy to Unravel the Molecular Mechanisms of Cardiac Reverse Remodeling Following Resynchronization Therapy?Journal of Clinical Medicine, 12(2), Article 665. https://doi.org/10.3390/jcm12020665
  • 2022
    • Wouters, P. C., van Everdingen, W. M., Vernooy, K., Geelhoed, B., Allaart, C. P., Rienstra, M., Maass, A. H., Vos, M. A., Prinzen, F. W., Meine, M., & Cramer, M. J. (2022). Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy?European Heart Journal Cardiovascular Imaging, 23(12), 1628-1635. https://doi.org/10.1093/ehjci/jeab264
    • Shahmohammadi, M., Huberts, W., Luo, H. X., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2022). Hemodynamics-driven mathematical model of third heart sound generation. Frontiers in physiology, 13, Article 847164. https://doi.org/10.3389/fphys.2022.847164
    • Ploeg, M. C., Munts, C., Seddiqi, T., ten Brink, T. J. L., Breemhaar, J., Moroni, L., Prinzen, F. W., & van Nieuwenhoven, F. A. (2022). Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor beta 1. Bioengineering, 9(10), Article 551. https://doi.org/10.3390/bioengineering9100551
    • Luo, H., Lamata, P., Bazin, S., Bautista, T., Barclay, N., Shahmohammadi, M., Lubrecht, J. M., Delhaas, T., & Prinzen, F. W. (2022). Smartphone as an electronic stethoscope: factors influencing heart sound quality. European Heart Journal - Digital Health, 3(3), 473-480. https://doi.org/10.1093/ehjdh/ztac044
    • Verzaal, N. J., van Deursen, C. J. M., Pezzuto, S., Wecke, L., van Everdingen, W. M., Vernooy, K., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2022). Synchronization of repolarization after cardiac resynchronization therapy: A combined clinical and modeling study. Journal of Cardiovascular Electrophysiology, 33(8), 1837-1846. https://doi.org/10.1111/jce.15581
    • Bouwmeester, S., Mast, T., Prinzen, F., Dekker, L., & Houthuizen, P. (2022). Predictive value of left atrial remodeling for response to cardiac resynchronization therapy. Journal of Ultrasonography, 22(90), E168-E173. https://doi.org/10.15557/JoU.2022.0027
    • Bouwmeester, S., van Loon, T., Ploeg, M., Mast, T. P., Verzaal, N. J., van Middendorp, L. B., Strik, M., van Nieuwenhoven, F. A., Dekker, L. R., Prinzen, F. W., Lumens, J., & Houthuizen, P. (2022). Left atrial remodeling in mitral regurgitation: A combined experimental-computational study. PLOS ONE, 17(7), Article e0271588. https://doi.org/10.1371/journal.pone.0271588
    • Bouwmeester, S., Mast, T. P., Keulards, D. C. J., de Lepper, A. G. W., Herold, I. H. F., Dekker, L. R., Prinzen, F. W., & Houthuizen, P. (2022). Left atrial reverse remodeling predicts long-term survival after cardiac resynchronization therapy. Journal of Echocardiography, 20(2), 115-123. https://doi.org/10.1007/s12574-021-00559-0
    • Rijks, J., Luermans, J., Heckman, L., van Stipdonk, A. M. W., Prinzen, F., Lumens, J., & Vernooy, K. (2022). Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing. Cardiac Electrophysiology Clinics, 14(2), 181-189. https://doi.org/10.1016/j.ccep.2021.12.010
    • Westphal, P., Luo, H. X., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2022). Left Ventricular Pressure Estimation Using Machine Learning-Based Heart Sound Classification. Frontiers in Cardiovascular Medicine, 9, Article 763048. https://doi.org/10.3389/fcvm.2022.763048
    • Prinzen, F. W., Auricchio, A., Mullens, W., Linde, C., & Huizar, J. F. (2022). Electrical management of heart failure: from pathophysiology to treatment. European Heart Journal, 43(20), 1917-1927. https://doi.org/10.1093/eurheartj/ehac088
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
    • Salden, F. C. W. M., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Atrioventricular dromotropathy: an important substrate for complete resynchronization therapy-Authors' reply. EP Europace, 24(5), 868-869. https://doi.org/10.1093/europace/euac037
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. https://doi.org/10.1093/europace/euab248
    • Ghossein, M. A., Driessen, R. G. H., van Rosmalen, F., Sels, J.-W. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., van Stipdonk, A. M. W., Prinzen, F. W., Ghossein-Doha, C., van Kuijk, S. M. J., van der Horst, I. C. C., Vernooy, K., & van Bussel, B. C. T. (2022). Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort). American Journal of Cardiology, 170, 118-127. https://doi.org/10.1016/j.amjcard.2022.01.030
    • Heckman, L. I. B., Luermans, J. G. L. M., Jastrzębski, M., Weijs, B., Van Stipdonk, A. M. W., Westra, S., den Uijl, D., Linz, D., Mafi-Rad, M., Prinzen, F. W., & Vernooy, K. (2022). A single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristics. Netherlands Heart Journal, 30(5), 249-257. https://doi.org/10.1007/s12471-022-01679-7
    • Ghossein, M. A., van Stipdonk, A. M., Prinzen, F. W., & Vernooy, K. (2022). Vectorcardiographic QRS area as a predictor of response to cardiac resynchronization therapy. Journal of Geriatric Cardiology, 19(1), 9-20. https://doi.org/10.11909/j.issn.1671-5411.2022.01.003
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