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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Uli Schotten

Professor

Professor Uli Schotten studied medicine at the universities of Aachen, Glasgow, and Valetta. After four years of training in cardiology at the University Hospital of Aachen, he joined the Department of Physiology at Maastricht University in 1998, first as a scholar of the Academy of Sciences of North-Rhine Westfalia and from 1999 on as a staff member of the department. He defended his thesis 'Mechanisms of Atrial Paralysis in Atrial Fibrillation' at Maastricht University in 2003, and received his habilitation in Experimental Cardiology at the University Hospital in Aachen in 2004. Since 2007, he is Principal Investigator at CARIM. In 2011, he was appointed Professor of Cardiac Electrophysiology and became chairman of the Department of Physiology in 2019.

His research interests include cellular and integrated actions of antiarrhythmic drugs, the development of substrates for the perpetuation of atrial fibrillation, invasive and non-invasive quantification of the substrate of atrial fibrillation, interaction between atrial fibrillation and activation of the coagulation system, and three-dimensional computer models of atrial fibrillation. He is coordinator of the CVON network RACE V and PI in numerous national and international research networks. He was member of the European task force for the development of the ESC guidelines for management of atrial fibrillation in 2010, 2012, and 2016. Furthermore, he is member of the Executive Committee of the Network of Competence for Atrial Fibrillation (AFNET), co-founder of the Maastricht University spin-off company YourRhythmics BV, and acts as the chairman of the Strategic board of CARIM.

Uli-schotten

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.130
T: +31(0)43 388 12 00

  • 2021
    • Hermans, B. J. M., Zink, M. D., van Rosmalen, F., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Pulmonary vein isolation in a real-world population does not influence QTc interval. EP Europace, 23, I48-I54. https://doi.org/10.1093/europace/euaa390
    • Linz, B., Hohl, M., Lang, L., Wong, D. W. L., Nickel, A. G., De La Torre, C., Sticht, C., Wirth, K., Boor, P., Maack, C., Speer, T., Jespersen, T., Schotten, U., Sanders, P., Bohm, M., & Linz, D. (2021). Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm, 18(3), 455-464. https://doi.org/10.1016/j.hrthm.2020.10.011
    • Heijman, J., Linz, D., & Schotten, U. (2021). Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annual Review of Physiology, 83, 83-106. https://doi.org/10.1146/annurev-physiol-031720-085307
    • Fenner, M. F., Gatta, G., Sattler, S., Kuiper, M., Hesselkilde, E. M., Adler, D. M. T., Smerup, M., Schotten, U., Sorensen, U., Diness, J. G., Jespersen, T., Verheule, S., Van Hunnik, A., & Buhl, R. (2021). Inhibition of Small-Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation. Frontiers in physiology, 12, Article 614483. https://doi.org/10.3389/fphys.2021.614483
    • Simons, S. O., Elliott, A., Sastry, M., Hendriks, J. M., Arzt, M., Rienstra, M., Kalman, J. M., Heidbuchel, H., Nattel, S., Wesseling, G., Schotten, U., van Gelder, I. C., Franssen, F. M. E., Sanders, P., Crijns, H. J. G. M., & Linz, D. (2021). Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective. European Heart Journal, 42(5), 532-540. https://doi.org/10.1093/eurheartj/ehaa822
    • Sobota, V., Gatta, G., van Hunnik, A., van Tuijn, I., Kuiper, M., Milnes, J., Jespersen, T., Schotten, U., & Verheule, S. (2021). The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats. Frontiers in Pharmacology, 11, Article 608410. https://doi.org/10.3389/fphar.2020.608410
    • Auricchio, A., Ozkartal, T., Salghetti, F., Neumann, L., Pezzuto, S., Gharaviri, A., Demarchi, A., Caputo, M. L., Regoli, F., De Asmundis, C., Chierchia, G. B., Brugada, P., Klersy, C., Moccetti, T., Schotten, U., & Conte, G. (2021). Short P-Wave Duration is a Marker of Higher Rate of Atrial Fibrillation Recurrences after Pulmonary Vein Isolation: New Insights into the Pathophysiological Mechanisms Through Computer Simulations. Journal of the American Heart Association, 10(2), Article 018572. https://doi.org/10.1161/JAHA.120.018572
    • Gharaviri, A., Pezzuto, S., Potse, M., Verheule, S., Conte, G., Krause, R., Schotten, U., & Auricchio, A. (2021). Left Atrial Appendage Electrical Isolation Reduces Atrial Fibrillation Recurrences A Simulation Study. Circulation-Arrhythmia and Electrophysiology, 14(1), Article e009230. https://doi.org/10.1161/CIRCEP.120.009230
  • 2020
    • Piccini, J. P., Todd, D. M., Massaro, T., Lougee, A., Haeusler, K. G., Blank, B., de Bono, J. P., Callans, D. J., Elvan, A., Fetsch, T., Van Gelder, I., Gentlesk, P., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H., Mont, L., Nielsen, J. C., Noelker, G., ... Kirchhof, P. (2020). Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation. Heart, 106(24), 1919-1926. https://doi.org/10.1136/heartjnl-2020-316612
    • Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U., & Verheule, S. (2020). JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling. Scientific Reports, 10(1), Article 20074. https://doi.org/10.1038/s41598-020-76932-3
    • Sutanto, H., Lyon, A., Lumens, J., Schotten, U., Dobrev, D., & Heijman, J. (2020). Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Progress in Biophysics & Molecular Biology, 157, 54-75. https://doi.org/10.1016/j.pbiomolbio.2020.02.008
    • Zeemering, S., van Hunnik, A., van Rosmalen, F., Bonizzi, P., Scaf, B., Delhaas, T., Verheule, S., & Schotten, U. (2020). A Novel Tool for the Identification and Characterization of Repetitive Patterns in High-Density Contact Mapping of Atrial Fibrillation. Frontiers in physiology, 11, Article 570118. https://doi.org/10.3389/fphys.2020.570118
    • Vagos, M. R., Arevalo, H., Heijman, J., Schotten, U., & Sundnes, J. (2020). A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics. Frontiers in physiology, 11, Article 556156. https://doi.org/10.3389/fphys.2020.556156
    • Kirchhof, P., Camm, A. J., Goette, A., Brandes, A., Eckardt, L., Elvan, A., Fetsch, T., van Gelder, I. C., Haase, D., Haegeli, L. M., Hamann, F., Heidbuchel, H., Hindricks, G., Kautzner, J., Kuck, K. H., Mont, L., Ng, G. A., Rekosz, J., Schoen, N., ... EAST-AFNET 4 Trial Investigators (2020). Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. New England Journal of Medicine, 383(14), 1305-1316. https://doi.org/10.1056/NEJMoa2019422
    • Zink, M. D., Chua, W., Zeemering, S., di Biase, L., Antoni, B. D., David, C., Hindricks, G., Haeusler, K. G., Al-Khalidi, H. R., Piccini, J. P., Mont, L., Nielsen, J. C., Escobar, L. A., de Bono, J., Van Gelder, I. C., de Potter, T., Scherr, D., Themistoclakis, S., Todd, D., ... Schotten, U. (2020). Predictors of recurrence of atrial fibrillation within the first 3 months after ablation. EP Europace, 22(9), 1337-1344. https://doi.org/10.1093/europace/euaa132
    • Bonizzi, P., Meste, O., Zeemering, S., Karel, J., Lankveld, T., Crijns, H., Schotten, U., & Peeters, R. (2020). A novel framework for noninvasive analysis of short-term atrial activity dynamics during persistent atrial fibrillation. Medical & Biological Engineering & Computing, 58(9), 1933-1945. https://doi.org/10.1007/s11517-020-02190-0
    • Fenner, M. F., Carstensen, H., Nissen, S. D., Hesselkilde, E. M., Lunddahl, C. S., Jensen, M. A. H., Loft-Andersen, A. V., Sather, S. M., Platonov, P., El-Haou, S., Jackson, C., Tang, R., Kirby, R., Ford, J., Schotten, U., Milnes, J., Sorensen, U. S., Jespersen, T., & Buhl, R. (2020). Effect of selective I K,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation. British Journal of Pharmacology, 177(16), 3778-3794. https://doi.org/10.1111/bph.15100
    • De With, R. R., Erkuner, O., Rienstra, M., Nguyen, B.-O., Korver, F. W. J., Linz, D., Ten, H. C., Spronk, H., Kroon, A. A., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., de Groot, J. R., Elvan, A., de Melis, M., Scheerder, C. O. S., Al-Jazairi, M. I. H., Schotten, U., ... RACE V Investigators (2020). Temporal patterns and short-term progression of paroxysmal atrial fibrillation data from RACE V. EP Europace, 22(8), 1162-1172. https://doi.org/10.1093/europace/euaa123
    • Manninger, M., Zweiker, D., Dobrovnik, M., van Hunnik, A., Rohrer, U., Zirngast, B., Herbst, V., Maechler, H., Schotten, U., Zirlik, A., & Scherr, D. (2020). Acute hyperglycaemia is not associated with the development of atrial fibrillation in healthy pigs. Scientific Reports, 10(1), Article 11881. https://doi.org/10.1038/s41598-020-68897-0
    • Kloosterman, M., Chua, W., Fabritz, L., Al-Khalidi, H. R., Schotten, U., Nielsen, J. C., Piccini, J. P., Di Biase, L., Hausler, K. G., Todd, D., Mont, L., Van Gelder, I. C., Kirchhof, P., & AXAFA-AFNET 5 Investigators (2020). Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5. EP Europace, 22(7), 1026-1035. https://doi.org/10.1093/europace/euaa015
    • Linz, B., Hohl, M., Mishima, R., Saljic, A., Lau, D. H., Jespersen, T., Schotten, U., Sanders, P., & Linz, D. (2020). Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats. IJC Heart & Vasculature, 28, Article 100534. https://doi.org/10.1016/j.ijcha.2020.100534
    • Gharaviri, A., Bidar, E., Potse, M., Zeemering, S., Verheule, S., Pezzuto, S., Krause, R., Maessen, J. G., Auricchio, A., & Schotten, U. (2020). Epicardial Fibrosis Explains Increased Endo-Epicardial Dissociation and Epicardial Breakthroughs in Human Atrial Fibrillation. Frontiers in physiology, 11, Article 68. https://doi.org/10.3389/fphys.2020.00068
  • 2019
    • Linz, D., Baumert, M., Desteghe, L., Kadhim, K., Vernooy, K., Kalman, J. M., Dobrev, D., Arzt, M., Sastry, M., Crijns, H. J. G. M., Schotten, U., Cowie, M. R., McEvoy, R. D., Heidbuchel, H., Hendriks, J., Sanders, P., & Lau, D. H. (2019). Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring. IJC Heart and Vasculature, 24, 1-7. Article 100424. https://doi.org/10.1016/j.ijcha.2019.100424
    • Linz, D., Elliott, A. D., Hohl, M., Malik, V., Schotten, U., Dobrev, D., Nattel, S., Boehm, M., Floras, J., Lau, D. H., & Sanders, P. (2019). Role of autonomic nervous system in atrial fibrillation. International Journal of Cardiology, 287, 181-188. https://doi.org/10.1016/j.ijcard.2018.11.091
    • Hohl, M., Erb, K., Lang, L., Ruf, S., Hübschle, T., Dhein, S., Linz, W., Elliott, A. D., Sanders, P., Zamyatkin, O., Böhm, M., Schotten, U., Sadowski, T., & Linz, D. (2019). Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion. JACC: Basic to Translational Science, 4(3), 332-344. https://doi.org/10.1016/j.jacbts.2019.01.008, https://doi.org/10.1016/j.jacbts.2019.01.008
    • Chua, W., Easter, C. L., Guasch, E., Sitch, A., Casadei, B., Crijns, H. J. G. M., Haase, D., Hatem, S., Kaab, S., Mont, L., Schotten, U., Sinner, M. F., Hemming, K., Deeks, J. J., Kirchhof, P., & Fabritz, L. (2019). Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset. BMC Cardiovascular disorders, 19(1), Article 120. https://doi.org/10.1186/s12872-019-1105-4
    • Conte, G., Schotten, U., & Auricchio, A. (2019). The Atrial Phenotype of the Inherited Primary Arrhythmia Syndromes. Arrhythmia & Electrophysiology Review, 8(1), 42-46. https://doi.org/10.15420/aer.2019.4.2
    • Dudink, E., Florijn, B., Weijs, B., Duijs, J., Luermans, J., Peeters, F., Schurgers, L., Wildberger, J., Schotten, U., Bijkerk, R., Crijns, H. J., & van Zonneveld, A. J. (2019). Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles. MicroRNA (Shāriqah, United Arab Emirates), 8(2), 127-134. https://doi.org/10.2174/2211536608666181122125208
  • 2018
    • Dudink, E. A. M. P., Weijs, B., Tull, S., Luermans, J. G. L. M., Fabritz, L., Chua, W., Rienstra, M., Van Gelder, I. C., Schotten, U., Kirchhof, P., & Crijns, H. J. G. M. (2018). The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation. Journal of Atrial Fibrillation, 11(4). https://doi.org/10.4022/jafib.2058
    • Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Krause, R., Auricchio, A., Kuijpers, N. H. L., & Schotten, U. (2018). Effect of Na+-channel blockade on the three-dimensional substrate of atrial fibrillation in a model of endo-epicardial dissociation and transmural conduction. EP Europace, 20(Suppl. 3), iii69-iii76. https://doi.org/10.1093/europace/euy236
    • Pezzuto, S., Gharaviri, A., Schotten, U., Potse, M., Conte, G., Caputo, M. L., Regoli, F., Krause, R., & Auricchio, A. (2018). Beat-to-beat P-wave morphological variability in patients with paroxysmal atrial fibrillation: an in silico study. EP Europace, 20, 26-35. https://doi.org/10.1093/europace/euy227
    • Podziemski, P., Zeemering, S., Kuklik, P., van Hunnik, A., Maesen, B., Maessen, J., Crijns, H. J., Verheule, S., & Schotten, U. (2018). Rotors Detected by Phase Analysis of Filtered, Epicardial Atrial Fibrillation Electrograms Colocalize With Regions of Conduction Block. Circulation-Arrhythmia and Electrophysiology, 11(10), Article e005858. https://doi.org/10.1161/CIRCEP.117.005858
    • Zhao, J., Schotten, U., Smaill, B., & Verheule, S. (2018). Loss of Side-to-Side Connections Affects the Relative Contributions of the Sodium and Calcium Current to Transverse Propagation Between Strands of Atrial Myocytes. Frontiers in physiology, 9(SEP), Article 1212. https://doi.org/10.3389/fphys.2018.01212
    • Manninger, M., Zweiker, D., van Hunnik, A., Alogna, A., Prassl, A. J., Schipke, J., Zeemering, S., Zirngast, B., Schonleitner, P., Schwarzl, M., Herbst, V., Thon-Gutschi, E., Huber, S., Rohrer, U., Ebner, J., Brussee, H., Pieske, B. M., Heinzel, F. R., Verheule, S., ... Scherr, D. (2018). Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation. Heart Rhythm, 15(9), 1328-1336. https://doi.org/10.1016/j.hrthm.2018.05.016
    • Kirchhof, P., Haeusler, K. G., Blank, B., De Bono, J., Callans, D., Elvan, A., Fetsch, T., Van Gelder, I. C., Gentlesk, P., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H. R., Massaro, T., Mont, L., Nielsen, J. C., Nolker, G., Piccini, J. P., De Potter, T., ... Di Biase, L. (2018). Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation. European Heart Journal, 39(32), 2942-2955. https://doi.org/10.1093/eurheartj/ehy176
    • van Hunnik, A., Zeemering, S., Podziemski, P., Simons, J., Gatta, G., Hannink, L., Maesen, B., Kuiper, M., Verheule, S., & Schotten, U. (2018). Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns. Frontiers in physiology, 9(JUL), Article 947. https://doi.org/10.3389/fphys.2018.00947
    • Zeemering, S., Lankveld, T. A. R., Bonizzi, P., Limantoro, I., Bekkers, S. C. A. M., Crijns, H. J. G. M., & Schotten, U. (2018). The electrocardiogram as a predictor of successful pharmacological cardioversion and progression of atrial fibrillation. EP Europace, 20(7), E96-E104. https://doi.org/10.1093/europace/eux234
    • Erkuner, O., Rienstra, M., Van Gelder, I. C., Schotten, U., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2018). Stroke risk in patients with device-detected atrial high-rate episodes. Netherlands Heart Journal, 26(4), 177-181. https://doi.org/10.1007/s12471-017-1047-3
    • Kotecha, D., Breithardt, G., Camm, A. J., Lip, G. Y. H., Schotten, U., Ahlsson, A., Arnar, D., Atar, D., Auricchio, A., Bax, J., Benussi, S., Blomstrom-Lundqvist, C., Borggrefe, M., Boriani, G., Brandes, A., Calkins, H., Casadei, B., Castella, M., Chua, W., ... Kirchhof, P. (2018). Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. EP Europace, 20(3), 395-407. https://doi.org/10.1093/europace/eux318
    • Zink, M. D., Marx, N., Crijns, H. J. G. M., & Schotten, U. (2018). Opportunities and challenges of large-scale screening for atrial fibrillation. Herzschrittmachertherapie und Elektrophysiologie, 29(1), 57-61. https://doi.org/10.1007/s00399-017-0550-y
    • Conte, G., Caputo, M. L., Volders, P. G. A., Luca, A., Mainardi, L., Schotten, U., Corino, V. D. A., Regoli, F., Zeemering, S., Zink, M., Yazdani, S., Kappenberger, L., Moccetti, T., Vesin, J.-M., & Auricchio, A. (2018). Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation. International Journal of Cardiology, 253, 66-70. https://doi.org/10.1016/j.ijcard.2017.09.214
    • Kotecha, D., Chua, W. W. L., Fabritz, L., Hendriks, J., Casadei, B., Schotten, U., Vardas, P., Heidbuchel, H., Dean, V., Kirchhof, P., & European Society Cardiology ESC; CATCH ME Consortium; EHRA (2018). European Society of Cardiology smartphone and tablet applications for patients with atrial fibrillation and their health care providers. EP Europace, 20(2), 225-233. https://doi.org/10.1093/europace/eux299
    • van Hunnik, A., Nasrallah, H., Lau, D. H., Kuiper, M., Verheule, S., & Schotten, U. (2018). Vernakalant does not alter early repolarization or contractility in normal and electrically remodelled atria. EP Europace, 20(1), 140-148. https://doi.org/10.1093/europace/eux025
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