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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Martina Calore

Assistant Professor

Dr Martina Calore has graduated in Biotechnology with specialisation in Human Genetics at Padova University. Subsequently, she obtained her PhD in Cardiovascular Sciences in Padova. During these years, she acquired a wide experience on genetic analyses performed both with traditional methods and with next generation sequencing (NGS) and on the interpretation of the variants detected in patients affected with inherited cardiomyopathies. She also focussed on the identification of novel genes involved in arrhythmogenic cardiomyopathy (ACM) by coupling genetic and functional studies. After her PhD, she collaborated with BMR genomics (Padova, Italy) in a project aimed at developing a technical and analytical strategy to analyze by NGS a panel of genes involved in different cardiomyopathies. In 2015, thanks to a Marie Sklodowska-Curie fellowship, she started working in the Department of Cardiology of Maastricht University under the supervision of Prof. Leon de Windt in order to investigate the role of microRNAs in the pathogenesis of ACM.

Since 2018, she has been Assistant Professor at Maastricht University. Her research is focussed on the generation of novel in vivo and in vitro models for ACM in order to study the pathogenic mechanisms of the disease and to develop novel therapeutic strategies. She supervises PhD students and is involved in teaching in the courses of Genetics and Molecular Biology at Maastricht Science Program and Human Genetics, Reproduction and Prenatal Development at the Faculty of Health, Medicine and Life Sciences.

Martina-calore

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.234
T: +31(0)43 388 43 01

  • 2024
    • Léger, L., Aalders, J., Heymans, N., Van Acker-Verberckt, K., De Bleeckere, L., Coucke, P., Menten, B., Bauce, B., Vitiello, L., Rampazzo, A., Calore, M., & van Hengel, J. (2024). Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing. Stem Cell Research, 81, Article 103537. https://doi.org/10.1016/j.scr.2024.103537
    • Vencato, S., Romanato, C., Rampazzo, A., & Calore, M. (2024). Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes. International Journal of Molecular Sciences, 25(11), Article 6208. https://doi.org/10.3390/ijms25116208
  • 2021
    • Sacchetto, C., Mohseni, Z., Colpaert, R. M. W., Vitiello, L., De Bortoli, M., Vonhogen, I. G. C., Xiao, K., Poloni, G., Lorenzon, A., Romualdi, C., Bariani, R., Mazzotti, E., Daliento, L., Bauce, B., Corrado, D., Thum, T., Rampazzo, A., de Windt, L. J., & Calore, M. (2021). Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Cells, 10(10), Article 2578. https://doi.org/10.3390/cells10102578
    • Schreurs, J., Sacchetto, C., Colpaert, R. M. W., Vitiello, L., Rampazzo, A., & Calore, M. (2021). Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases. International Journal of Molecular Sciences, 22(20), Article 10985. https://doi.org/10.3390/ijms222010985
    • Colpaert, R. M. W., & Calore, M. (2021). Epigenetics and microRNAs in cardiovascular diseases. Genomics, 113(2), 540-551. https://doi.org/10.1016/j.ygeno.2020.12.042
  • 2020
    • Vonhogen, I. G. C., Mohseni, Z., Winkens, B., Xiao, K., Thum, T., Calore, M., Martins, P. A. D. C., de Windt, L. J., Spaanderman, M. E. A., & Ghossein-Doha, C. (2020). Circulating miR-216a as a biomarker of metabolic alterations and obesity in women. Non-Coding rna research, 5(3), 144-152. https://doi.org/10.1016/j.ncrna.2020.08.001
    • Sacchetto, C., Vitiello, L., de Windt, L. J., Rampazzo, A., & Calore, M. (2020). Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures. International Journal of Molecular Sciences, 21(9), Article 3404. https://doi.org/10.3390/ijms21093404
    • De Bortoli, M., Vio, R., Basso, C., Calore, M., Minervini, G., Angelini, A., Melacini, P., Vitiello, L., Vazza, G., Thiene, G., Tosatto, S., Corrado, D., Iliceto, S., Rampazzo, A., & Calore, C. (2020). Novel Missense Variant in MYL2 Gene Associated With Hypertrophic Cardiomyopathy Showing High Incidence of Restrictive Physiology. Circulation: Genomic and Precision Medicine, 13(2), Article 002824. https://doi.org/10.1161/circgen.119.002824
  • 2019
    • Sacchetto, C., Sequeira, V., Bertero, E., Dudek, J., Maack, C., & Calore, M. (2019). Metabolic Alterations in Inherited Cardiomyopathies. Journal of Clinical Medicine, 8(12), Article 2195. https://doi.org/10.3390/jcm8122195
    • Calore, M., Poloni, G., Postma, A. V., Lorenzon, A., Minervini, G., Vazza, G., Li Mura, I. E. A., Telatin, A., Zara, I., Simionati, B., Ponti, J., Occhi, G., Vitiello, L., Bauce, B., Tosatto, S. C. E., van Tintelen, P. J., Rampazzo, A., & De Bortoli, M. (2019). Next Generation Sequencing identifies novel variants in TJP1, TP63 and PPP1R13L genes in Arrhythmogenic Cardiomyopathy patients. European Journal of Human Genetics, 27, 1304-1305. https://doi.org/10.1038/s41431-019-0494-2
    • Calore, M., Lorenzon, A., Vitiello, L., Poloni, G., Beffagna, G., Dazzo, E., Polishchuk, R., Sabatelli, P., Doliana, R., Carnevale, D., Lembo, G., Bonaldo, P., de Windt, L. J., Braghetta, P., & Rampazzo, A. (2019). A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt/b-catenin signaling and miRNA dysregulation. European Journal of Human Genetics, 27, 842-842.
    • Colpaert, R. M. W., & Calore, M. (2019). MicroRNAs in Cardiac Diseases. Cells, 8(7), Article 737. https://doi.org/10.3390/cells8070737
    • Poloni, G., Calore, M., Rigato, I., Marras, E., Minervini, G., Mazzotti, E., Lorenzon, A., Li Mura, I. E. A., Telatin, A., Zara, I., Simionati, B., Marra, M. P., Ponti, J., Occhi, G., Vitiello, L., Daliento, L., Thiene, G., Basso, C., Corrado, D., ... De Bortoli, M. (2019). A targeted next-generation gene panel reveals a novel heterozygous nonsense variant in the TP63 gene in patients with arrhythmogenic cardiomyopathy. Heart Rhythm, 16(5), 773-780. https://doi.org/10.1016/j.hrthm.2018.11.015
    • Calore, M., Lorenzon, A., Vitiello, L., Poloni, G., Khan, M. A. F., Beffagna, G., Dazzo, E., Sacchetto, C., Polishchuk, R., Sabatelli, P., Doliana, R., Carnevale, D., Lembo, G., Bonaldo, P., De Windt, L., Braghetta, P., & Rampazzo, A. (2019). A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation. Cardiovascular Research, 115(4), 739-751. https://doi.org/10.1093/cvr/cvy253
    • Raso, A., Dirkx, E., Philippen, L. E., Fernandez-Celis, A., De Majo, F., Sampaio-Pinto, V., Sansonetti, M., Juni, R., el Azzouzi, H., Calore, M., Bitsch, N., Olieslagers, S., Oerlemans, M. I. F. J., Huibers, M. M., de Weger, R. A., Reckman, Y. J., Pinto, Y. M., Zentilin, L., Zacchigna, S., ... De Windt, L. J. (2019). Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure. Molecular Therapy, 27(3), 584-599. https://doi.org/10.1016/j.ymthe.2018.11.011
  • 2018
    • Mohseni, Z., Spaanderman, M. E. A., Oben, J., Calore, M., Derksen, E., Al-Nasiry, S., De Windt, L. J., & Ghossein-Doha, C. (2018). Cardiac remodeling and pre-eclampsia: an overview of microRNA expression patterns. Ultrasound in Obstetrics & Gynecology, 52(3), 310-317. https://doi.org/10.1002/uog.17516
    • De Majo, F., & Calore, M. (2018). Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart. Non-coding RNA research, 3(1), 20-28. https://doi.org/10.1016/j.ncrna.2018.02.003
  • 2017
    • Lorenzon, A., Calore, M., Poloni, G., De Windt, L. J., Braghetta, P., & Rampazzo, A. (2017). Wnt/beta-catenin pathway in arrhythmogenic cardiomyopathy. Oncotarget, 8(36), 60640-60655. https://doi.org/10.18632/oncotarget.17457
    • Calore, M. (2017). The PRKAG2 gene and hypertrophic cardiomyopathy: an energetically imbalanced relationship. American Journal of Physiology-heart and Circulatory Physiology, 313(2), H248-H250. https://doi.org/10.1152/ajpheart.00316.2017
  • 2016
    • Poloni, G., De Bortoli, M., Calore, M., Rampazzo, A., & Lorenzon, A. (2016). Arrhythmogenic right-ventricular cardiomyopathy: molecular genetics into clinical practice in the era of next generation sequencing. Journal of Cardiovascular Medicine, 17(6), 399-407. https://doi.org/10.2459/JCM.0000000000000385
  • 2015
    • Calore, M., De Windt, L. J., & Rampazzo, A. (2015). Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases. Journal of Molecular and Cellular Cardiology, 89, 27-34. https://doi.org/10.1016/j.yjmcc.2015.10.028
    • Calore, M., & De Windt, L. J. (2015). Longing for Naiades in Heart Failure. Journal of the American College of Cardiology, 66(18), 2016-2018. https://doi.org/10.1016/j.jacc.2015.08.868
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