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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Amée Buziau

Post doc

Dr Amée Buziau obtained her master’s degree Nutrition and Health at Wageningen University & Research. During her studies, she conducted her bachelor internship at the Human Nutrition Unit at The University of Auckland (New Zealand) and her master internship at the School of Public Health at the University of Queensland (Australia). In 2018, she started her PhD research at CARIM under supervision of Prof. Martijn Brouwers, Prof. Coen Stehouwer, and Prof. Casper Schalkwijk. During her PhD-trajectory, she focused on the role of fructose in the pathogenesis of intrahepatic lipid accumulation, for which she employed multiple research methodologies, including genetic epidemiology (Mendelian randomization), nutritional epidemiology, experiments with humans, and mice experiments.

 

In 2023, Amée was awarded the CARIM Postdoctoral Talent Fellowship to fund the first year of her postdoctoral research. This postdoctoral research was performed at the Stem Cell Institute Leuven (Belgium) in the group of Prof. Catherine Verfaillie. Her postdoctoral research focused on generating human induced pluripotent stem cells (hiPSC) and subsequently differentiating these hiPSC into hepatocytes, to further study the mechanisms of fructose-mediated intrahepatic lipid accumulation in vitro. Subsequently, she was granted a 3-year personal Junior Fellowship from the Dutch Diabetes Foundation to study the role of the pentose-phosphate pathway in the pathogenesis of fructose-mediated intrahepatic lipid accumulation by using hiPSC-derived hepatocytes, large epidemiological studies, and genetic epidemiology (Mendelian randomization).

Ame buziau

Department ofInternal Medicine
Universiteitssingl 60, 6229 ER Maastricht 
PO Box 616, 6200 MD Maastricht

  • 2024
    • Buziau, A. M., Oosterveer, M. H., Wouters, K., Bos, T., Tolan, D. R., Agius, L., Ford, B. E., Cassiman, D., Stehouwer, C. D. A., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2024). Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in ALDOB deficiency. Molecular Metabolism, 87, Article 101984. https://doi.org/10.1016/j.molmet.2024.101984
    • Chen, H., Buziau, A. M., Renteria, M. E., Simons, P. I. H. G., & Brouwers, M. C. G. J. (2024). Fructose intake from sugar-sweetened beverages is associated with a greater risk of hyperandrogenism in women: UK Biobank cohort study. European Journal of Endocrinology, 190(1), 104-112. https://doi.org/10.1093/ejendo/lvae006
  • 2023
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2023). Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults. Metabolism open, 18(1), Article 100245. https://doi.org/10.1016/j.metop.2023.100245
    • Buziau, A. M., Blokland, G. A. M., Schalkwijk, C. G., Scheijen, J. L. J. M., Simons, P. I. H. G., Eussen, S. J. P. M., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2023). Comment on Lee et al. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care 2022;45. Diabetes Care, 46(4), E97-E98. https://doi.org/10.2337/dc22-1930
    • Buziau, A. M., Law, P. J., Blokland, G., Schalkwijk, C., Scheijen, J., Simons, P., van der Kallen, C., Eussen, S., Dagnelie, P. C., van Greevenbroek, M., Houlston, R. S., Wesselius, A., Went, M., Stehouwer, C., & Brouwers, M. C. (2023). Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study. Gut, 72(3), 604-606. https://doi.org/10.1136/gutjnl-2021-326299
  • 2022
    • Buziau, A. M., Eussen, S. J. P. M., Kooi, M. E., van der Kallen, C. J. H., van Dongen, M. C. J. M., Schaper, N. C., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Bekers, O., Meex, S. J. R., Schalkwijk, C. G., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes Care, 45(5), 1116-1123. https://doi.org/10.2337/dc21-2123
  • 2020
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Simons, N., Brouwers, M. C. G. J., & Schalkwijk, C. G. (2020). Development and validation of a UPLC-MS/MS method to quantify fructose in serum and urine. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1155, Article 122299. https://doi.org/10.1016/j.jchromb.2020.122299
    • Buziau, A. M., Schalkwijk, C. G., Stehouwer, C. D. A., Tolan, D. R., & Brouwers, M. C. G. J. (2020). Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease. Cellular and Molecular Life Sciences, 77(9), 1709-1719. https://doi.org/10.1007/s00018-019-03348-2
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