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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Kristiaan Wouters

Associate professor

Dr Kristiaan Wouters has studied Biomedical Sciences at Hasselt University (Belgium). In 2003, he started his PhD research at the Dept. of Molecular Genetics at Maastricht University on the role of macrophages and inflammation in nonalcoholic fatty liver disease. After obtaining his PhD in 2008, he worked as a post-doc in the laboratory of Prof. Bart Staels at the Pasteur Institute in Lille, France, on the role of macrophage polarisation in obesity, diabetes, and atherosclerosis. Kristiaan has returned to Maastricht at the Dept. of Internal Medicine as tenure track researcher setting up his research group 'Translational Immunometabolism'. Since 2019, he has been appointed as Associate Professor.

The group focusses on the immunological events in adipose tissue during obesity and the impact of these events on cardiometabolic complications, such as type 2 diabetes, cardiovascular disease and nonalcoholic fatty liver disease, with a specific focus on the interplay between metabolism and inflammation in innate immune cells.

Current projects focus on the role of reactive dicarbonyls formed during glycolysis on immune cell function in cardiometabolic diseases, and on multivariate analysis of flow cytometry data.

 

 

Kristiaan-wouters

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H5.310
T: +31(0)43 388 42 33

  • 2015
    • Legein, B., Janssen, E. M., Theelen, T. L., Gijbels, M. J., Walraven, J., Klarquist, J. S., Hennies, C. M., Wouters, K., Seijkens, T. T. P., Wijnands, E., Sluimer, J. C., Lutgens, E., Zenke, M., Hildner, K., Biessen, E. A. L., & Temmerman, L. (2015). Ablation of CD8 alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Scientific Reports, 5, Article 15414. https://doi.org/10.1038/srep15414
    • Hannou, S. A., Wouters, K., Paumelle, R., & Staels, B. (2015). Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?Trends in Endocrinology and Metabolism, 26(4), 176-184. https://doi.org/10.1016/j.tem.2015.01.008
  • 2014
    • Hanssen, N. M. J., Brouwers, O., Gijbels, M. J., Wouters, K., Wijnands, E., Cleutjens, J. P. M., De Mey, J. G., Miyata, T., Biessen, E. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE(-/-) mice with or without diabetes. Cardiovascular Research, 104(1), 160-170. https://doi.org/10.1093/cvr/cvu189
    • Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., de Kleijn, D. P., Stehouwer, C. D. A., Pasterkamp, G., & Schalkwijk, C. G. (2014). Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. European Heart Journal, 35(17), 1137-1146. https://doi.org/10.1093/eurheartj/eht402
  • 2013
    • Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E., Custers, K., Peters, T., Hazebroek, M., Stoger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schurmann, N., Vigorito, E., Thum, T., Stassen, F. R., Yin, X., ... Schroen, B. L. (2013). Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure. Circulation, 128(13), 1420-1432. https://doi.org/10.1161/CIRCULATIONAHA.112.001357
  • 2012
    • Tailleux, A., Wouters, K., & Staels, B. (2012). Roles of PPARs in NAFLD: potential therapeutic targets. Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides, 1821(5), 809-18. https://doi.org/10.1016/j.bbalip.2011.10.016
    • Bieghs, V., Verheyen, F., van Gorp, P. J., Hendrikx, T., Wouters, K., Lutjohann, D., Gijbels, M. J., Febbraio, M., Binder, C. J., Hofker, M. H., & Sverdlov, R. (2012). Internalization of modified lipids by cd36 and sr-a leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells. PLOS ONE, 7(3), Article e34378. https://doi.org/10.1371/journal.pone.0034378
    • Wouters, K., Cudejko, C., Gijbels, M. J. J., Fuentes, L., Bantubungi, K., Vanhoutte, J., Dievart, R., Paquet, C., Bouchaert, E., Hannou, S. A., Gizard, F., Tailleux, A., de Winther, M. P. J., Staels, B., & Paumelle, R. (2012). Bone Marrow p16(INK4a)-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development. PLOS ONE, 7(3), e32440. https://doi.org/10.1371/journal.pone.0032440
    • Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., de Bakker, J., Binder, C. J., Lutjohann, D., Staels, B., Hofker, M. H., & Sverdlov, R. (2012). LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLOS ONE, 7(1), Article e30668. https://doi.org/10.1371/journal.pone.0030668
  • 2011
    • Cudejko, C., Wouters, K., Fuentes, L., Hannou, S. A., Paquet, C., Bantubungi, K., Bouchaert, E., Vanhoutte, J., Fleury, S., Remy, P., Tailleux, A., Chinetti-Gbaguidi, G., Dombrowicz, D., Staels, B., & Paumelle, R. (2011). p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages. Blood, 118(9), 2556-66. https://doi.org/10.1182/blood-2010-10-313106
    • Lalloyer, F., Wouters, K., Baron, M., Caron, S., Vallez, E., Vanhoutte, J., Bauge, E., Sverdlov, R., Hofker, M., Staels, B., & Tailleux, A. (2011). Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. Arteriosclerosis Thrombosis and Vascular Biology, 31(7), 1573-1579. https://doi.org/10.1161/ATVBAHA.110.220525
  • 2010
    • Bieghs, V., Wouters, K., van Gorp, P. J., Gijbels, M. J. J., de Winther, M. P. J., Binder, C. J., Lutjohann, D., Febbraio, M., Moore, K. J., van Bilsen, M., Hofker, M. H., & Shiri-Sverdlov, R. (2010). Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology, 138(7), 2477-2486. https://doi.org/10.1053/j.gastro.2010.02.051
    • Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lutjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Sverdlov, R. (2010). Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice.Febs Letters, 584(5), 1001-1005. https://doi.org/10.1016/j.febslet.2010.01.046
  • 2008
    • Wouters, K., van Gorp, P. J. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lutjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., van Bilsen, M., Sverdlov, R., & Hofker, M. H. (2008). Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology, 48(2), 474-486. https://doi.org/10.1002/hep.22363
    • Vanschoonbeek, K., Wouters, K., van der Meijden, P. E., van Gorp, P. J. J., Feijge, M. A., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P., & Heemskerk, J. W. (2008). Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.Arteriosclerosis Thrombosis and Vascular Biology, 28(11), 2023-2029. https://doi.org/10.1161/ATVBAHA.107.156992
  • 2006
    • Shiri-Sverdlov, R., Wouters, K., van Gorp, P. J. J., Gijbels, M. J. J., Noel, B., Buffat, L., Staels, B., Maeda, N., van Bilsen, M., & Hofker, M. H. (2006). Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. Journal of Hepatology, 44(4), 732-741. https://doi.org/10.1016/j.jhep.2005.10.033
  • 2005
    • Wouters, K. A. M., Shiri-Sverdlov, R., van Gorp, P. J. J., van Bilsen, M., & Hofker, M. H. (2005). Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice. Clinical Chemistry and Laboratory Medicine, 43(5), 470-479. https://doi.org/10.1515/CCLM.2005.085
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