Publications
- 2024
- Wynants, L., Broers, N., Platteel, T., Venekamp, R., Barten, D., Leers, M., Verheij, T., Stassen, P., Cals, J., & de Bont, E. (2024). Development and validation of a risk prediction model for hospital admission in COVID-19 patients presenting to primary care. European Journal of General Practice, 30(1), Article 2339488. https://doi.org/10.1080/13814788.2024.2339488
- Mokhtar, S. B. A., Viljoen, J., van der Kallen, C. J. H., Berendschot, T. T. J. M., Dagnelie, P. C., Albers, J. D., Soeterboek, J., Scarpa, F., Colonna, A., van der Heide, F. C. T., van Greevenbroek, M. M. J., Bosm, H., Kroon, A. A., Nuijts, R. M. M. A., Gijs, M., Lakerveld, J., Malik, R. A., Webers, C. A. B., Stehouwer, C. D. A., & Koster, A. (2024). Greater exposure to PM<inf>2.5</inf> and PM<inf>10</inf> was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study. Environmental Health, 23(1), Article 70. https://doi.org/10.1186/s12940-024-01110-1
- van Hilten, A., van Rooij, J., Heijmans, B. T., ’t Hoen, P. A. C., Meurs, J. V., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., ... BIOS Consortium (2024). Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data. NPJ systems biology and applications, 10(1), Article 81. https://doi.org/10.1038/s41540-024-00405-w
- Stangl, T. A., Wiepjes, C. M., Smit, R. A. J., van Hylckama Vlieg, A., Lamb, H. J., van der Velde, J. H. P. M., Winters van Eekelen, E., Boone, S. C., Brouwers, M. C. G. J., Rosendaal, F. R., den Heijer, M., Heijboer, A. C., & de Mutsert, R. (2024). Association Between Low Sex Hormone-Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: results from observational and Mendelian randomization analyses. Diabetes, 73(11), 1793-1804. https://doi.org/10.2337/db23-0982
- Meisters, R., Koster, A., Albers, J., Sezer, B., van Greevenbroek, M., de Galan, B., & Bosma, H. (2024). Early life socioeconomic inequalities and type 2 diabetes incidence: Longitudinal analyses in the Maastricht study. Diabetes Research and Clinical Practice, 217, Article 111855. https://doi.org/10.1016/j.diabres.2024.111855
- van Hulten, V., Souverein, P. C., Starup-Linde, J., Viggers, R., Klungel, O. H., Vestergaard, P., Brouwers, M. C. J. G., van den Bergh, J. P., & Driessen, J. H. M. (2024). The association of type 2 diabetes-related characteristics with fracture risk at different sites. Diabetes Obesity & Metabolism, 26(11), 4887-4896. https://doi.org/10.1111/dom.15884
- van Oeteren, M. A. J., Simons, N., Simons, P. I. H. G., van de Waarenburg, M. P. H., Kooi, M. E., Feskens, E. J. M., van der Ploeg, E. M. C. L., Van den Eynde, M. D. G., Houben, A. J. H. M., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2024). Fructose restriction has beneficial effects on adipose tissue distribution but not on serum adipokine levels: Post-hoc analysis of a double-blind randomized controlled trial. Clinical Obesity, Article 12714. Advance online publication. https://doi.org/10.1111/cob.12714
- Coral, D. E., Smit, F., Farzaneh, A., Gieswinkel, A., Tajes, J. F., Sparsø, T., Delfin, C., Bauvain, P., Wang, K., Temprosa, M., De Cock, D., Blanch, J., Fernández-Real, J. M., Ramos, R., Ikram, M. K., Gomez, M. F., Kavousi, M., Panova-Noeva, M., Wild, P. S., ... Franks, P. W. (2024). Subclassification of obesity for precision prediction of cardiometabolic diseases. Nature Medicine. https://doi.org/10.1038/s41591-024-03299-7
- Soeterboek, J., Deckers, K., van Boxtel, M. P. J., Backes, W. H., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Jansen, J. F. A., Koster, A., Schram, M. T., Stehouwer, C. D. A., Wesselius, A., Lakerveld, J., Bosma, H., & Köhler, S. (2024). Association of ambient air pollution with cognitive functioning and markers of structural brain damage: The Maastricht study. Environment International, 192, Article 109048. https://doi.org/10.1016/j.envint.2024.109048
- Chan, J. A., Koster, A., Lakerveld, J., Schram, M. T., van Greevenbroek, M., & Bosma, H. (2024). Associations of neighborhood social cohesion and changes in BMI-The Maastricht Study. European Journal of Public Health, 34(5), 949-954. https://doi.org/10.1093/eurpub/ckae109
- Beran, M., Jansen, W. J., Oomens, J. E., Moonen, J. E. F., Slagboom, P. E., Huisman, M., Kok, A. A. L., Nooyens, A. C. J., Verschuren, W. M. M., Stehouwer, C. D. A., Schalkwijk, C., Kohler, S., Beekman, M., Slagboom, P. E., Wolters, F. J., Ikram, M. A., Vallerga, C. L., van Meurs, J. B. J., Ghanbari, M., ... NCDC Consortium (2024). Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis. Alzheimer's & Dementia. Advance online publication. https://doi.org/10.1002/alz.14272
- van den Kerkhof, M., de Jong, J. J. A., Voorter, P. H. M., Postma, A., Kroon, A. A., van Oostenbrugge, R. J., Jansen, J. F. A., & Backes, W. H. (2024). Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study. Hypertension, 81(10), 2162-2172. https://doi.org/10.1161/HYPERTENSIONAHA.123.22617
- Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2024). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology. Advance online publication. https://doi.org/10.1007/s12035-024-04552-3
- Holthuijsen, D. D. B., van Roekel, E. H., Bours, M. J. L., Ueland, P. M., Breukink, S. O., Janssen-Heijnen, M. L. G., Keulen, E. T. P., Brezina, S., Gigic, B., Peoples, A. R., Ulrich, C. M., Ulvik, A., Weijenberg, M. P., & Eussen, S. J. P. M. (2024). Longitudinal associations of plasma kynurenines and ratios with fatigue and quality of life in colorectal cancer survivors up to 12 months post-treatment. International Journal of Cancer, 155(7), 1172-1190. https://doi.org/10.1002/ijc.34992
- Zhao, X., Schalkwijk, C., Kroon, A., Schram, M. T., Stehouwer, C., & Houben, A. (2024). Different Measures of Hyperglycemia Are Negatively Associated With Skin Microvascular Flowmotion: The Maastricht Study. Microcirculation, 31(7), Article e12882. https://doi.org/10.1111/micc.12882
- Sun, D., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., Kelly, J., Schalkwijk, C. G., & Wouters, K. (2024). Methylglyoxal mediates the association between 2-hour plasma glucose and HbA1c with inflammation: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism. Advance online publication. https://doi.org/10.1210/clinem/dgae640
- Ward, R. A., Forget, G., Lindekilde, N., Deschênes, S. S., Pouwer, F., Schmitz, N., Schram, M., & Burns, R. J. (2024). Anger Expression Styles, Cynical Hostility, and the Risk for the Development of Type 2 Diabetes or Diabetes-Related Heart Complications: Secondary Analysis of the Health and Retirement Study. Psychosomatic medicine, Article 10.1097/PSY.0000000000001344. https://doi.org/10.1097/PSY.0000000000001344
- Sezer, B., Albers, J., Meisters, R., Schram, M. T., Köhler, S., Stehouwer, C. D. A., Koster, A., & Bosma, H. (2024). Do poor psychosocial resources mediate health inequalities in type 2 diabetes mellitus? Findings from the Maastricht study. European Journal of Public Health, Article ckae139. https://doi.org/10.1093/eurpub/ckae139
- Van Hulten, V., Driessen, J. H. M., Andersen, S., Kvist, A., Viggers, R., Bliuc, D., Center, J. R., Brouwers, M. C. J. G., Vestergaard, P., & van den Bergh, J. P. (2024). Fracture risk revisited: Bone mineral density T-score and fracture risk in type 2 diabetes. Diabetes Obesity & Metabolism, 26(11), 5325-5335. https://doi.org/10.1111/dom.15890
- Adam, S., Maas, S. L., Huchzermeier, R., Rakateli, L., Abschlag, K., Hohl, M., Liao, L., Bartneck, M., Teunissen, M., Wouters, K., Santovito, D., Jankowski, J., Biessen, E. A. L., & van der Vorst, E. P. C. (2024). The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis. EBioMedicine, 107, Article 105293. https://doi.org/10.1016/j.ebiom.2024.105293
- Van Hulten, V., Sarodnik, C., Driessen, J. H. M., Viggers, R., Rasmussen, N. H., Geusens, P. P. M. M., Schaper, N., Schram, M. T., De Galan, B. E., Koster, A., Bours, S. P. G., Vestergaard, P., Stehouwer, C. D. A., & van den Bergh, J. P. (2024). Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes: the Maastricht study. JBMR plus, 8(9), Article ziae086. https://doi.org/10.1093/jbmrpl/ziae086
- Buziau, A. M., Oosterveer, M. H., Wouters, K., Bos, T., Tolan, D. R., Agius, L., Ford, B. E., Cassiman, D., Stehouwer, C. D. A., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2024). Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in ALDOB deficiency. Molecular Metabolism, 87, Article 101984. https://doi.org/10.1016/j.molmet.2024.101984
- Veldhuizen, G. P., Alnazer, R. M., Kroon, A. A., Spaanderman, M. E. A., & de Leeuw, P. W. (2024). Variable effect of the post-partum menstrual cycle on aldosterone and renin in women with recent preeclampsia. Journal of Human Hypertension, 38(9), 649-654. https://doi.org/10.1038/s41371-024-00926-1
- Beran, M., Twait, E. L., Smit, A. P., Posthuma, M. F., van Dijk, D., Rabanal, K. M., Rosado, D., Flores, R. J., Qian, C. L., Samuel, S. S., Ying, G., Mayeux, R., van Sloten, T. T., Schram, M. T., Manly, J. J., Geerlings, M. I., & Vonk, J. M. J. (2024). The Association of Sociodemographic Factors With Total and Item-Level Semantic Fluency Metrics. Neuropsychology, 38(7), 665-678. https://doi.org/10.1037/neu0000955
- D'Haese, S., Claes, L., Jaeken, E., Deluyker, D., Evens, L., Heeren, E., Haesen, S., Vastmans, L., Lambrichts, I., Wouters, K., Schalkwijk, C. G., Hansen, D., Eijnde, B. O., & Bito, V. (2024). Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. International Journal of Molecular Sciences, 25(15), Article 8508. https://doi.org/10.3390/ijms25158508
- Geraets, A. F. J., Schram, M. T., Jansen, J. F. A., Kohler, S., van Boxtel, M. P. J., Eussen, S. J. P. M., Koster, A., Stehouwer, C. D. A., Bosma, H., & Leist, A. K. (2024). The associations of socioeconomic position with structural brain damage and connectivity and cognitive functioning: The Maastricht Study. Social Science & Medicine, 355, Article 117111. https://doi.org/10.1016/j.socscimed.2024.117111
- Li, J., Roshelli Baker, J., Aglago, E. K., Zhao, Z., Jiao, L., Freisling, H., Hughes, D. J., Eriksen, A. K., Tjønneland, A., Severi, G., Katzke, V., Kaaks, R., Schulze, M. B., Masala, G., Pala, V., Pasanisi, F., Tumino, R., Padroni, L., Vermeulen, R. C. H., ... Fedirko, V. (2024). Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients. International Journal of Cancer, 155(11), 1982-1995. Advance online publication. https://doi.org/10.1002/ijc.35114
- Vangrieken, P., Al-Nasiry, S., Remels, A. H. V., Schiffers, P. M. H., Janssen, E., Nass, S., Scheijen, J. L. J. M., Spaanderman, M. E. A., & Schalkwijk, C. G. (2024). Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications. Hypertension, 81(7), 1537-1549. https://doi.org/10.1161/HYPERTENSIONAHA.123.22633
- Brakenridge, C. J., Koster, A., de Galan, B. E., Carver, A., Dumuid, D., Dzakpasu, F. Q. S., Eussen, S. J. P. M., Savelberg, H. H. C. M., Bosma, H., Owen, N., Schaper, N. C., Healy, G. N., & Dunstan, D. W. (2024). Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study. Diabetologia, 67(7), 1356-1367. https://doi.org/10.1007/s00125-024-06145-0
- Dagnelie, P. C., Willems, P. C., & Jorgensen, N. R. (2024). Nutritional status as independent prognostic factor of outcome and mortality until five years after hip fracture: a comprehensive prospective study. Osteoporosis International, 35(7), 1273-1287. https://doi.org/10.1007/s00198-024-07088-3
- Weijers, J., Prins, M. L. M., van Dam, D. G. H. A., van Nieuwkoop, C., Alsma, J., Haak, H. R., V Uffen, J. W., Kaasjager, K. A. H., Kremers, M. N. T., Nanayakkara, P. W. B., Stassen, P. M., Groeneveld, G. H., & AcuteCare@Home Study Group (2024). Patients' Perspectives and Feasibility of Home Monitoring in Acute Care: The AcuteCare@Home Flash Mob Study. Telemedicine and E-health. Advance online publication. https://doi.org/10.1089/tmj.2024.0166
- Truin, L. S., Kohler, S., Heger, I. S., van Boxtel, M. P. J., Schram, M. T., Backes, W. H., Jansen, J. F. A., van Dongen, M. M. C. J. M., de Vries, N. K., de Vries, H., Eussen, S. J. P. M., Stehouwer, C. D. A., de Vugt, M. E., & Deckers, K. (2024). Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study. British Journal of Psychiatry, 224(6), 189-197. https://doi.org/10.1192/bjp.2023.159
- van Dam, P. M. E. L., Pena, R. E. L., Mommertz, J. A., Borggreve, H. F., van Loon, N. P. H., Zelis, N., Westerman, D., Henry, R. M. A., Posthouwer, D., Cals, J. W. L., & Stassen, P. M. (2024). Acute internal medicine physicians' clinical intuition based on acute care telephone referral: A prospective study. PLOS ONE, 19(6), Article e0305566. https://doi.org/10.1371/journal.pone.0305566
- Debras, C., Cordova, R., Mayén, A.-L., Maasen, K., Knaze, V., Eussen, S. J., Schalkwijk, C. G., Huybrechts, I., Tjønneland, A., Halkjær, J., Katzke, V., Bajracharya, R., Schulze, M. B., Masala, G., Pala, V., Pasanisi, F., Macciotta, A., Petrova, D., Castañeda, J., ... Freisling, H. (2024). Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults. British Journal of Nutrition, 131(11), 1902-1914. https://doi.org/10.1017/S0007114524000503
- Rombaut, B., Schepers, M., Tiane, A., Mussen, F., Koole, L., Kessels, S., Trippaers, C., Jacobs, R., Wouters, K., Willems, E., Veggel, L. V., Koulousakis, P., Deluyker, D., Bito, V., Prickaerts, J., Wens, I., Brône, B., van den Hove, D. L. A., & Vanmierlo, T. (2024). Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice. Cells, 13(12), Article 1000. https://doi.org/10.3390/cells13121000
- Brouwers, M. C., & Cassiman, D. (2024). Rare monogenic causes of steatotic liver disease masquerading as MASLD. Journal of Hepatology, 80(6), e252-e253. https://doi.org/10.1016/j.jhep.2024.02.025
- Mateus, P., Moonen, J., Beran, M., Jaarsma, E., van der Landen, S. M., Heuvelink, J., Birhanu, M., Harms, A. G. J., Bron, E., Wolters, F. J., Cats, D., Mei, H., Oomens, J., Jansen, W., Schram, M. T., Dekker, A., & Bermejo, I. (2024). Data harmonization and federated learning for multi-cohort dementia research using the OMOP common data model: A Netherlands consortium of dementia cohorts case study. Journal of biomedical informatics, 155, Article 104661. https://doi.org/10.1016/j.jbi.2024.104661
- DeJong, N. R., Jansen, J. F. A., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Koster, A., Eussen, S. J. P. M., de Galan, B. E., Backes, W. H., & Köhler, S. (2024). Brain structure and connectivity mediate the association between lifestyle and cognition: The Maastricht Study. Brain Communications, 6(3), Article fcae171. https://doi.org/10.1093/braincomms/fcae171
- Chong, M. Y., Frenken, K. G., Eussen, S. J. P. M., Koster, A., Pot, G. K., Breukink, S. O., Janssen-Heijnen, M., Keulen, E. T. P., Bijnens, W., Buffart, L. M., Meijer, K., Scheer, F. A. J. L., Steindorf, K., de Vos-Geelen, J., Weijenberg, M. P., van Roekel, E. H., & Bours, M. J. L. (2024). Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment. International Journal of Behavioral Nutrition and Physical Activity, 21(1), Article 51. https://doi.org/10.1186/s12966-024-01601-x
- Lear, R., Metcalf, B., Hillsdon, M., Bond, B., Koster, A., Vandercappellen, E., de Galan, B., Berendschot, T. T. J. M., Houben, A., Kooman, J., Kroon, A. A., Bosma, H., Eussen, S. J. P. M., & Pulsford, R. (2024). Associations of between- and within-day patterns of physical activity accumulation with arterial stiffness and indices of microvascular health—Evidence from The Maastricht study. Scandinavian Journal of Medicine & Science in Sports, 34(5), Article e14649. https://doi.org/10.1111/sms.14649
- den Brok, E. J., Svensson, C. H., Panagiotou, M., van Greevenbroek, M. M. J., Mertens, P. R., Vazeou, A., Mitrakou, A., Makrilakis, K., Franssen, G. H. L. M., van Kuijk, S., Proennecke, S., Mougiakakou, S., Pedersen-Bjergaard, U., de Galan, B. E., & Melissa Consortium (2024). The effect of bolus advisors on glycaemic parameters in adults with diabetes on intensive insulin therapy: A systematic review with meta-analysis. Diabetes Obesity & Metabolism, 26(5), 1950-1961. https://doi.org/10.1111/dom.15521
- Chan, J. A., Bosma, H., Lakerveld, J., Schram, M. T., van Greevenbroek, M., & Koster, A. (2024). Social cohesion and associations with sedentary time, physical activity and dietary quality in The Maastricht Study. Preventive Medicine, 183, Article 107970. https://doi.org/10.1016/j.ypmed.2024.107970
- Claassen, L., Ritter, L. M., Latten, G. H. P., Zelis, N., Cals, J. W. L., & Stassen, P. M. (2024). From symptom onset to ED departure: understanding the acute care chain for patients with undifferentiated complaints. International Journal of Emergency Medicine, 17(1), Article 55. https://doi.org/10.1186/s12245-024-00629-x
- Chong, M. Y., Eussen, S. J. P. M., van Roekel, E. H., Pot, G. K., Koster, A., Breukink, S. O., Janssen-Heijnen, M. L. G., Keulen, E. T. P., Stehouwer, C. D. A., Weijenberg, M. P., & Bours, M. J. L. (2024). Longitudinal associations of circadian eating patterns with sleep quality, fatigue, and inflammation in colorectal cancer survivors up to 24 months post-treatment. British Journal of Nutrition, 131(7), 1166-1180. https://doi.org/10.1017/S0007114523002714
- Werkman, N. C. C., García-Sáez, G., Nielen, J. T. H., Tapia-Galisteo, J., Somolinos-Simón, F. J., Hernando, M. E., Wang, J., Jiu, L., Goettsch, W. G., van der Kallen, C. J. H., Koster, A., Schalkwijk, C. G., de Vries, H., de Vries, N. K., Eussen, S. J. P. M., Driessen, J. H. M., & Stehouwer, C. D. A. (2024). Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study. Diabetologia, 67(4), 690-702. https://doi.org/10.1007/s00125-023-06082-4
- Baylan, U., Baidoshvili, A., Simsek, S., Schalkwijk, C. G., Niessen, H., & Krijnen, P. (2024). Increased accumulation of the advanced glycation endproduct Ne(carboxymethyl) lysine in the intramyocardial vasculature in patients with epicarditis. International Journal of Experimental Pathology, 105(2), 48-51. https://doi.org/10.1111/iep.12499
- Ren, Z., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2024). Relationship between educational attainment and non-alcoholic fatty liver disease: A two-sample Mendelian randomization study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 56(4), 565-570. https://doi.org/10.1016/j.dld.2023.11.040
- van Gennip, A. C. E., Gupta, M. D., Houben, A. J. H. M., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Koster, A., Wesselius, A., Eussen, S. J. P. M., Schalkwijk, C. G., de Galan, B. E., Köhler, S., Schram, M. T., Stehouwer, C. D. A., & van Sloten, T. T. (2024). Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study. Psychological Medicine, 1-10. Advance online publication. https://doi.org/10.1017/S0033291724000618
- van Doorn, W. P. T. M., Helmich, F., van Dam, P. M. E. L., Jacobs, L. H. J., Stassen, P. M., Bekers, O., & Meex, S. J. R. (2024). Explainable Machine Learning Models for Rapid Risk Stratification in the Emergency Department: A Multicenter Study. Journal of Applied Laboratory Medicine, 9(2), 212-222. Article jfad094. https://doi.org/10.1093/jalm/jfad094
- Betz, M. W., Hendriks, F. K., Houben, A. J. H. M., Van Den Eynde, M. D. G., Verdijk, L. B., Van Loon, L. J. C., & Snijders, T. (2024). Type II Muscle Fiber Capillarization Is an Important Determinant of Post-Exercise Microvascular Perfusion in Older Adults. Gerontology, 70(3), 290-301. https://doi.org/10.1159/000535831