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CARIM's Confidential Contact Persons

CARIM's Confidential Contact Persons

27 November 2024

Dr Magdi Nagy (Dept of Biochemistry) and Prof. Peter de Leeuw (Dept of Internal Medicine) have been appointed as CARIM Confidential Contact Persons.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

27 November 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.

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Carim Maastricht
Carim Maastricht

Julie Staals

Professor

Prof.  Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

Julie Staals  has been appointed as professor 'Neurovascular disease' as of 1 April 2024. Julie is neurologist at Maastricht UMC+ and leader of the stroke clinic. Her research aims at unravelling the pathophysiology of cerebral small vessel disease, a common ageing-related disease leading to stroke and dementia, which falls within the research programs of both CARIM and MHeNS. Furthermore she is involved in clinical studies on the very successfull acute endovascular stroke treatment. The inaugural lecture will follow later.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)

 

Julie-staals

Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2025
    • Ruthmann, F., Lo, J. W., Mendyk-Bordet, A.-M., Allart, E., Köhler, S., Klimkowicz-Mrowiec, A., Staals, J., Sachdev, P. S., Bordet, R., Dondaine, T., & Stroke and Cognition (STROKOG) Collaboration (2025). Prevalence of poststroke anxiety and its associations with global cognitive impairment: An individual participant data analysis. Journal of Affective Disorders, 369, 1136-1144. Advance online publication. https://doi.org/10.1016/j.jad.2024.10.099
  • 2024
    • Robbe, M. M. Q., Pinckaers, F. M. E., Wagemans, B. A. J. M., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2024). Additional value of CTP maps in occlusion detection on CTP angiographic reconstructions for ischemic stroke. European Journal of Radiology, 181, Article 111789. https://doi.org/10.1016/j.ejrad.2024.111789
    • Peeters, M. T. J., Postma, A. A., van Oostenbrugge, R. J., Henneman, W. J. P., & Staals, J. (2024). Dual-energy CT angiography in detecting underlying causes of intracerebral hemorrhage: an observational cohort study. Neuroradiology. https://doi.org/10.1007/s00234-024-03473-1
    • Fandler-Höfler, S., Eppinger, S., Ambler, G., Nash, P., Kneihsl, M., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martínez-Domeño, A., Inamura, S., Yoshifuji, K., ... Microbleeds International Collaborative Network (2024). Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds. Jama network open, 7(10), Article e2439571. https://doi.org/10.1001/jamanetworkopen.2024.39571
    • Coenen, M., de Kort, F. A. S., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Bordet, R., Chen, C. L., Dewenter, A., Doeven, T., Dondaine, T., Duering, M., Fang, R., van der Giessen, R. S., Kim, J., Kim, B. J., de Kort, P. L. M., Koudstaal, P., Lee, M., ... Biesbroek, J. M. (2024). Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment: a multicenter study in 1568 stroke patients. International journal of stroke, 19(8), 916-924. https://doi.org/10.1177/17474930241252530
    • van Dinther, M., Voorter, P. H. M., Zhang, E., van Kuijk, S. M. J., Jansen, J. F. A., van Oostenbrugge, R. J., Backes, W. H., & Staals, J. (2024). The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach. Geroscience, 46(5), 5061-5073. https://doi.org/10.1007/s11357-024-01235-8
    • Knapen, R. R. M. M., Goldhoorn, R.-J. B., Hofmeijer, J., Lycklamaa Nijeholt, G. J., van den Berg, R., van den Wijngaard, I. R., van Oostenbrugge, R. J., van Zwam, W. H., van der Leij, C., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Hinsenveld, W., Staals, J., Postma - Jacobi, L., Brans, R., Olthuis, S., & Pinckaers, F. (2024). Balloon Guide Catheter Versus Non-Balloon Guide Catheter: A MR CLEAN Registry Analysis. Stroke: vascular and interventional neurology, 4(4), Article e001103. https://doi.org/10.1161/SVIN.123.001103
    • Starmans, N. L. P., Wolters, F. J., Leeuwis, A. E., Bron, E. E., de Bresser, J., Brunner-La Rocca, H. P., Staals, J., Muller, M., Biessels, G. J., Kappelle, L. J., & Heart-Brain Connection Consortium (2024). Orthostatic hypotension, cognition and structural brain imaging in hemodynamically impaired patients. Journal of the Neurological Sciences, 461, Article 123026. https://doi.org/10.1016/j.jns.2024.123026
    • Van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H., Marquering, H. A., De Jong, H. W. A. M., Berkhemer, O. A., Van Zwam, W. H., Van Walderveen, M. A. A., Van Den Wijngaard, I. R., Dippel, D. W. J., Yoo, A. J., Campbell, B., Kunz, W. G., Majoie, C. B., Emmer, B. J., ... MR CLEAN Registry Investigators (2024). Costs and health effects of CT perfusion-based selection for endovascular thrombectomy within 6 hours of stroke onset: a model-based health economic evaluation. Journal of Neurology Neurosurgery and Psychiatry, 95(6), 515-527. https://doi.org/10.1136/jnnp-2023-331862
    • van der Knaap, N., de Vreeze, F., van Rosmalen, F., Wintjens, M. S. J. N., van Santen, S., Linden, D. E. J., Staals, J., van Mook, W. N. K. A., Jansen, J. F. A., van der Horst, I. C. C., van Bussel, B. C. T., & Ariës, M. J. H. (2024). The incidence of neurological complications in mechanically ventilated COVID-19 ICU patients: An observational single-center cohort study in three COVID-19 periods. Clinical Neurology and Neurosurgery, 241, Article 108311. https://doi.org/10.1016/j.clineuro.2024.108311
    • Senff, J. R., Singh, S. D., Pasi, M., Jolink, W. M. T., Rodrigues, M. A., Schreuder, F. H. B. M., Staals, J., Schreuder, T., Douwes, J. P. J., Talsma, J., McKaig, B. N., Kourkoulis, C., Yechoor, N., Anderson, C. D., Puy, L., Cordonnier, C., Wermer, M. J. H., Rothwell, P. M., Rosand, J., ... Brouwers, H. B. (2024). Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study. Stroke, 55(5), 1210-1217. https://doi.org/10.1161/STROKEAHA.123.044622
    • Prats-Sanchez, L., Camps-Renom, P., Nash, P. S., Wilson, D., Ambler, G., Best, J. G., Guasch-Jiménez, M., Ramos-Pachón, A., Martinez-Domeño, A., Lambea-Gil, Á., Díaz, G. E., Guisado-Alonso, D., Du, H., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y., Ay, H., Jung, S., Bornstein, N. M., ... Microbleeds International Collaborative Network (MICON) (2024). Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. Neurology, 102(7), Article e209173. https://doi.org/10.1212/WNL.0000000000209173
    • van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H. F., Beenen, L. F. M., de Jong, H. W. A. M., Berkhemer, O. A., van Zwam, W. H., Roos, Y. B. W. E. M., van Walderveen, M. A. A., van den Wijngaard, I., Dippel, D. W. J., Yoo, A. J., Campbell, B. C. V., Kunz, W. G., Emmer, B. J., ... MR CLEAN Registry Investigators (2024). Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study. European Radiology, 34(4), 2152-2167. https://doi.org/10.1007/s00330-023-10119-y
    • Oestreich, L. K., Lo, J. W., Di Biase, M. A., Sachdev, P. S., Mok, A. H., Wright, P., Crawford, J. D., Lam, B., Traykov, L., Köhler, S., Staals, J. E., van Oostenbrugge, R., Chen, C., Desmond, D. W., Yu, K.-H., Lee, M., Klimkowicz-Mrowiec, A., Bordet, R., O'Sullivan, M. J., & Zalesky, A. (2024). Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets. Psychiatry and Clinical Neurosciences, 78(4), 229-236. https://doi.org/10.1111/pcn.13633
    • Robbe, M. M. Q., Pinckaers, F. M. E., Olthuis, S. G. H., Bos, M. J., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2024). Procedural Blood Pressure and Intracranial Hemorrhage on Dual-Energy Computed Tomography After Endovascular Stroke Treatment. Cardiovascular and Interventional Radiology, 47(4), 483-491. https://doi.org/10.1007/s00270-023-03619-3
    • Robbe, M. M. Q., Pinckaers, F. M. E., Santegoeds, R. G. C., Bos, M. J., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2024). Procedural blood pressure and contrast extravasation on dual energy computed tomography after endovascular stroke treatment. Journal of Stroke & Cerebrovascular Diseases, 33(6), Article 107673. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107673
    • Wardlaw, J. M., Chabriat, H., de Leeuw, F.-E., Debette, S., Dichgans, M., Doubal, F., Jokinen, H., Katsanos, A. H., Ornello, R., Pantoni, L., Pasi, M., Pavlovic, A. M., Rudilosso, S., Schmidt, R., Staals, J., Taylor-Rowan, M., Hussain, S., & Lindgren, A. G. (2024). European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke. European Stroke Journal, 9(1), 5-68. Article 23969873231219416. https://doi.org/10.1177/23969873231219416
    • Hoving, J. W., Konduri, P. R., Tolhuisen, M. L., Koopman, M. S., van Voorst, H., Van Poppel, L. M., Daems, J. D., van Es, A. C. G. M., van Walderveen, M. A. A., Lingsma, H. F., Dippel, D. W. J., Van Zwam, W. H., Marquering, H. A., Majoie, C. B. L. M., Emmer, B. J., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., Goldhoorn, R.-J., Hinsenveld, W., ... Pinckaers, F. (2024). Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke. Journal of Cardiovascular Development and Disease, 11(3), Article 80. https://doi.org/10.3390/jcdd11030080
    • Voorter, P. H. M., van Dinther, M., Jansen, W. J., Postma, A. A., Staals, J., Jansen, J. F. A., van Oostenbrugge, R. J., van der Thiel, M. M., & Backes, W. H. (2024). Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. Journal of Magnetic Resonance Imaging, 59(2), 397-411. Article jmri28989. https://doi.org/10.1002/jmri.28989
    • Knapen, R. R. M. M., Pirson, F. A. V., Langezaal, L. C. M., Brouwer, J., Majoie, C. B. L. M., Emmer, B. J., Vos, J.-A., van Doormaal, P.-J., Yoo, A. J., Bruggeman, A. A. E., Lycklama À Nijeholt, G. J., van der Leij, C., van Oostenbrugge, R. J., van Zwam, W. H., Schonewille, W. J., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Hinsenveld, W., Staals, J., ... Pirson, A.-F. (2024). Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study. Stroke, 55(2), 403-412. https://doi.org/10.1161/STROKEAHA.123.043777
    • Best, J. G., Ambler, G., Wilson, D., Du, H., Lee, K.-J., Lim, J.-S., Teo, K. C., Mak, H., Kim, Y. D., Song, T.-J., Selcuk Demirelli, D., Nishihara, M., Yoshikawa, M., Kubacka, M., Zietz, A., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y. H., Panos, L., ... Werring, D. J. (2024). Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA: A Pooled Analysis. Neurology, 102(1), Article e207795. https://doi.org/10.1212/WNL.0000000000207795
    • van Dinther, M. M., Hooghiemstra, A. E., Bron, E., Versteeg, A. E., Leeuwis, A., Kalay, T. E., Moonen, J., Kuipers, S. H., Backes, W., Jansen, J. F. A., van Osch, M. J. P., Biessels, G.-J., Staals, J. J., van Oostenbrugge, R., & Heart-Brain Connection Consortium (2024). Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimer's & Dementia, 20(1), 136-144. https://doi.org/10.1002/alz.13408
    • Starmans, N. L. P., Kappelle, L. J., Muller, M., Staals, J., Teunissen, C. E., Biessels, G. J., van der Flier, W. M., Wolters, F. J., & Heart-Brain Connection Consortium (2024). Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis. Journal of Alzheimer's Disease, 99(4), 1207-1215. https://doi.org/10.3233/JAD-240119
    • Stiekema, A. P. M., Vreven, L. W. A., Hummel, R. S. O., Mott, A. S., Verrijt, S. J. G. M., Joe, R. C. K., Alberto, N. A. S., Ravindran, P. K., Thommes, C., van der Kwaak, A., Staals, J., & van Heugten, C. M. (2024). The Montreal Cognitive Assessment detects cognitive deficits that go unnoticed during clinical observation in the acute phase after stroke. Brain Injury, 38(9), 687-691. https://doi.org/10.1080/02699052.2024.2341039
  • 2023
    • de Kort, F. A. S., Coenen, M., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Bordet, R., Cammà, G., Chen, C. P. L. H., Dewenter, A., Duering, M., Fang, R., van der Giessen, R. S., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kan, C. N., Kim, J., Kim, B. J., ... Biessels, G. J. (2023). White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies. Stroke, 54(12), 3021–3029. https://doi.org/10.1161/STROKEAHA.123.044297
    • Bakker, L., Ramakers, I. H. G. B., J P M Eussen, S., Choe, K., van den Hove, D. L. A., Kenis, G., Rutten, B. P. F., van Oostenbrugge, R. J., Staals, J., Ulvik, A., Ueland, P. M., Verhey, F. R. J., & Köhler, S. (2023). The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. Journal of the neurological sciences, 454(1), Article 120819. https://doi.org/10.1016/j.jns.2023.120819
    • Kopczak, A., Stringer, M. S., van den Brink, H., Kerkhofs, D., Blair, G. W., van Dinther, M., Reyes, C. A., Garcia, D. J., Onkenhout, L., Wartolowska, K. A., Thrippleton, M. J., Kampaite, A., Duering, M., Staals, J., Lesnik-Oberstein, S., Muir, K. W., Middeke, M., Norrving, B., Bousser, M. G., ... TREAT-SVDs collaborators (2023). Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurology, 22(11), 991-1004. https://doi.org/10.1016/S1474-4422(23)00293-4
    • Elschot, E. P., Backes, W. H., de Jong, J. J. A., Drenthen, G. S., Wong, S. M., Staals, J., Postma, A. A., Rouhl, R. P. W., van Oostenbrugge, R. J., & Jansen, J. F. A. (2023). Assessment of the clinical feasibility of detecting subtle blood-brain barrier leakage in cerebral small vessel disease using dynamic susceptibility contrast MRI. Magnetic Resonance Imaging, 102(1), 55-61. https://doi.org/10.1016/j.mri.2023.04.004
    • van Lanen, R. H. G. J., Haeren, R. H. L., Staals, J., Dings, J. T. A., Schijns, O. E. M. G., Hoogland, G., van Kuijk, S. M. J., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Vink, H., Rijkers, K., & ACE Epilepsy Surgery Group (2023). Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy. Journal of Cerebral Blood Flow and Metabolism, 43(10), 1737-1751. https://doi.org/10.1177/0271678X231179413
    • Voorter, P. H. M., Backes, W. H., Gurney-Champion, O. J., Wong, S.-M., Staals, J., van Oostenbrugge, R. J., van Der Thiel, M. M., Jansen, J. F. A., & Drenthen, G. S. (2023). Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magnetic Resonance in Medicine, 90(4), 1657 - 1671. https://doi.org/10.1002/mrm.29753
    • Rudilosso, S., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G. W., Garcia, D. J., Doubal, F., Hamilton, I., Janssen, E., Kopczak, A., Ingrisch, M., Kerkhofs, D., Backes, W. H., Staals, J., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2023). Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 43(9), 1490-1502. https://doi.org/10.1177/0271678X231173444
    • Schaper, F. L. W. V. J., Nordberg, J., Cohen, A. L., Lin, C., Hsu, J., Horn, A., Ferguson, M. A., Siddiqi, S. H., Drew, W., Soussand, L., Winkler, A. M., Simo, M., Bruna, J., Rheims, S., Guenot, M., Bucci, M., Nummenmaa, L., Staals, J., Colon, A. J., ... Fox, M. D. (2023). Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology, 80(9), 891-902. https://doi.org/10.1001/jamaneurol.2023.1988
    • Exalto, L. G., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Best, J. G., Bordet, R., Chen, C. P. L. H., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kim, J., Kappelle, L. J., Kim, B. J., Köhler, S., de Kort, P. L. M., ... Biessels, G. J. (2023). Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke. Stroke, 54(9), 2296-2303. https://doi.org/10.1161/STROKEAHA.123.042507
    • Manukjan, N., Majcher, D., Leenders, P., Caiment, F., van Herwijnen, M., Smeets, H. J. J., Suidgeest, E., van der Weerd, L., Vanmierlo, T., Jansen, J. F. A., Backes, W. H. H., van Oostenbrugge, R. J. J., Staals, J., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023). Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment. Acta neuropathologica communications, 11(1), Article 128. https://doi.org/10.1186/s40478-023-01627-5
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Soo, Y., Zietz, A., Yiu, B., Mok, V. C. T., Polymeris, A. A., Seiffge, D., Ambler, G., Wilson, D., Leung, T. W. H., Tsang, S. F., Chu, W., Abrigo, J., Cheng, C., Lee, K.-J., Lim, J.-S., Shiozawa, M., Koga, M., Chabriat, H., Hennerici, M., ... Peters, N. (2023). Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation. Annals of Neurology, 94(1), 61-74. https://doi.org/10.1002/ana.26642
    • Duering, M., Biessels, G. J., Brodtmann, A., Chen, C., Cordonnier, C., de Leeuw, F.-E., Debette, S., Frayne, R., Jouvent, E., Rost, N. S., ter Telgte, A., Salman, R. A.-S., Backes, W. H., Bae, H.-J., Brown, R., Chabriat, H., De Luca, A., deCarli, C., Dewenter, A., ... Et al. (2023). Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurology, 22(7), 602-618. https://doi.org/10.1016/S1474-4422(23)00131-X
    • Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H. J., Lim, J. S., Godefroy, O., Roussel, M., Köhler, S., Staals, J., Verhey, F., Chen, C., Xu, X., Chong, E. J., Kandiah, N., Bordet, R., Dondaine, T., Mendyk, A. M., Brodaty, H., Traykov, L., ... Sachdev, P. S. (2023). Short-term Trajectories of Poststroke Cognitive Function: A STROKOG Collaboration Study. Neurology, 100(23), E2331-E2341. https://doi.org/10.1212/WNL.0000000000207281
    • Starmans, N. L., Wolters, F. J., Leeuwis, A. E., Bron, E. E., La Rocca, H. P. B., Staals, J., Biessels, G. J., & Kappelle, L. J. (2023). Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities. Journal of Cerebral Blood Flow and Metabolism, 43(5), 801-811. https://doi.org/10.1177/0271678X221149937
    • Olthuis, S. G. H., Pirson, F. A. V., Pinckaers, F. M. E., Hinsenveld, W. H., Nieboer, D., Ceulemans, A., Knapen, R. R. M. M., Robbe, M. M. Q., Berkhemer, O. A., van Walderveen, M. A. A., Lycklama À Nijeholt, G. J., Uyttenboogaart, M., Schonewille, W. J., van der Sluijs, P. M., Wolff, L., van Voorst, H., Postma, A. A., Roosendaal, S. D., van der Hoorn, A., ... MR CLEAN-LATE Investigators (2023). Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial. Lancet, 401(10385), 1371-1380. https://doi.org/10.1016/S0140-6736(23)00575-5
    • Brouwer, J., Ergezen, S., Mulder, M. J. H. L., Nijeholt, G. J. L. A., Van Es, A. C. G. M., Van Der Lugt, A., Dippel, D. W. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M., Coutinho, J. M., Emmer, B. J., Van Oostenbrugge, R. J., Van Zwam, W. H., Boiten, J., Vos, J. A., Jansen, I. G. H., Goldhoorn, R. J. B., Compagne, K. C. J., Kappelhof, M., ... MR CLEAN Registry Investigators (2023). Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry. Journal of Neurointerventional Surgery, 15(4), 363-369. https://doi.org/10.1136/neurintsurg-2021-018505
    • Olthuis, S. G. H., Hinsenveld, W. H., Pinckaers, F. M. E., Amini, M., Lingsma, H. F., Staals, J., Schreuder, T. H. C. M. L., Schonewille, W. J., Yo, L. S. F., Roos, Y. B. W. E. M., Postma, A. A., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., de Ridder, I. R., & MR CLEAN Registry Investigators (2023). Association between type of intervention center and outcomes after endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry. European Stroke Journal, 8(1), 224-230. https://doi.org/10.1177/23969873221145771
    • Kopczak, A., Stringer, M. S., van den Brink, H., Kerkhofs, D., Blair, G. W., van Dinther, M., Onkenhout, L., Wartolowska, K. A., Thrippleton, M. J., Duering, M., Staals, J., Middeke, M., Andre, E., Norrving, B., Bousser, M. G., Mansmann, U., Rothwell, P. M., Doubal, F. N., van Oostenbrugge, R., ... SVDs@Target Investigators (2023). The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial. European Stroke Journal, 8(1), 387-397. https://doi.org/10.1177/23969873221143570
    • Olthuis, S. G. H., den Hartog, S. J., van Kuijk, S. M. J., Staals, J., Benali, F., van der Leij, C., Beumer, D., Nijeholt, G. J. L. A., Uyttenboogaart, M., Martens, J. M., Van Doormaal, P. J., Vos, J. A., Emmer, B. J., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., de Ridder, I. R., & MR CLEAN Registry Investigators (2023). Influence of the interventionist's experience on outcomes of endovascular thrombectomy in acute ischemic stroke: results from the MR CLEAN Registry. Journal of Neurointerventional Surgery, 15(2), 113-119. https://doi.org/10.1136/neurintsurg-2021-018295
    • van Dinther, M., Bennett, J., Thornton, G. D., Voorter, P. H. M., Casajus, A. E., Hughes, A., Captur, G., Holtackers, R. J., Staals, J., Backes, W. H., Bastarika, G., Jones, E. A. V., Gonzalez, A., van Oostenbrugge, R., Treibel, T. A., & CRUCIAL Consortium (2023). Evaluation of miCRovascular rarefaction in vascUlar Cognitive Impairment and heArt faiLure (CRUCIAL): Study protocol for an observational study. Cerebrovascular Diseases Extra, 13(1), 18-32. https://doi.org/10.1159/000529067
  • 2022
    • van der Steen, W., van der Sluijs, P. M., van de Graaf, R. A., Su, R., Wolff, L., van Voorst, H., den Hertog, H. M., van Doormaal, P. J., van Es, A. C. G. M., Staals, J., van Zwam, W., Lingsma, H. F., van den Berg, R., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., Roozenbeek, B., & MR CLEAN-MED investigators (2022). Safety and efficacy of periprocedural antithrombotics in patients with successful reperfusion after endovascular stroke treatment. Journal of Stroke & Cerebrovascular Diseases, 31(10), Article 106726. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106726
    • van Dinther, M., Voorter, P. H. M., Schram, M. T., Berendschot, T. T. J. M., Houben, A. J. H. M., Webers, C. A. B., van Oostenbrugge, R. J., Backes, W. H., Staals, J., & Jansen, J. F. A. (2022). Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI. Journal of the Neurological Sciences, 440, Article 120359. https://doi.org/10.1016/j.jns.2022.120359
    • Rudilosso, S., Chui, E., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G., GarcÃa, D. J., Doubal, F., Hamilton, I., Kopczak, A., Ingrish, M., Kerkhofs, D., Backes, W. H., Staals, J., van Oostenbrugge, R., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2022). Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease. Neurology, 99(5), E440-E452. https://doi.org/10.1212/WNL.0000000000200614
    • Pirson, F. A. V. A., Boodt, N., Brouwer, J., Bruggeman, A. A. E., Hinsenveld, W. H., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Dippel, D. W. J., van der Lugt, A., Schonewille, W. J., van Oostenbrugge, R. J., & MR CLEAN Registry Investigators (2022). Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry. Stroke, 53(8), 2468-2477. https://doi.org/10.1161/strokeaha.121.038054
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, Article 577863. https://doi.org/10.1016/j.jneuroim.2022.577863
Overview