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CARIM's Confidential Contact Persons

CARIM's Confidential Contact Persons

27 November 2024

Dr Magdi Nagy (Dept of Biochemistry) and Prof. Peter de Leeuw (Dept of Internal Medicine) have been appointed as CARIM Confidential Contact Persons.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

27 November 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.

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Carim Maastricht
Carim Maastricht

Robert van Oostenbrugge

Professor

Robert van Oostenbrugge is Professor of Neurology, with a chair on Vascular Neurology, head of the Department of Neurology (UM); principal Investigator of CARIM and programme leader of Vascular Neurology / Stroke. Robert (R.J.) van Oostenbrugge; (born Havelte, 1965) obtained a MD at the Maastricht University in Maastricht (1990). He was registered as neurologist in 2000 and obtained a PhD in 1999 (University Maastricht, Maastricht). In 2013, he was appointed Professor of Neurology chair of the Department of Neurology at Maastricht University. He is member of the Centers of Excellence in Neurodegeneration initiative and of the JPND funded initiative HARNESS aiming to harmonise imaging standards in vascular dementia, member of the board of the Dutch Section of Vascular Neurology.

Robert-van-oostenbrugge

Department of Neurology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31 (0)43 387 70 58

 

  • 2016
    • Berkhemer, O. A., Jansen, I. G. H., Beumer, D., Fransen, P. S. S., van den Berg, L. A., Yoo, A. J., Lingsma, H. F., Sprengers, M. E. S., Jenniskens, S. F. M., Lycklama a Nijeholt, G. J., van Walderveen, M. A. A., van den Berg, R., Bot, J. C. J., Beenen, L. F. M., Boers, A. M. M., Slump, C. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Dippel, D. W. J., ... Majoie, C. B. L. M. (2016). Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke. Stroke, 47(3), 768-776. https://doi.org/10.1161/STROKEAHA.115.011788
    • Santos, E. M. M., Marquering, H. A., den Blanken, M. D., Berkhemer, O. A., Boers, A. M. M., Yoo, A. J., Beenen, L. F., Treurniet, K. M., Wismans, C., van Noort, K., Lingsma, H. F., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Niessen, W. J., & Majoie, C. B. (2016). Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke. Stroke, 47(3), 732-741. https://doi.org/10.1161/STROKEAHA.115.011187
    • MR CLEAN Investigators, van Zwam, W., & van Oostenbrugge, R. J. (2016). Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke. Neuroradiology, 58(2), 133-139. https://doi.org/10.1007/s00234-015-1607-4
    • Fransen, P. S. S., Berkhemer, O. A., Lingsma, H. F., Beumer, D., van den Berg, L. A., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2016). Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke A Randomized Clinical Trial. JAMA Neurology, 73(2), 190-196. https://doi.org/10.1001/jamaneurol.2015.3886
    • MR CLEAN Investigators, van Oostenbrugge, R. J., & van Zwam, W. (2016). Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke. PLOS ONE, 11(1), Article e0145641. https://doi.org/10.1371/journal.pone.0145641
    • Rost, N. S., Bottle, A., Lee, J. M., Randall, M., Middleton, S., Shaw, L., Thijs, V., Rinkel, G. J. E., Hemmen, T. M., Global Comparators Stroke GOAL collaborators, Eleopra, R., van Oostenbrugge, R. J., Fenwick, C., Pelly, M., Vaux, E., van Wyk, A., Spencer, M., Peggy, G., Matzkiw, H., & Newman, J. (2016). Stroke severity is a crucial predictor of outcome: An international prospective validation study. Journal of the American Heart Association, 5(1), 1-7. https://doi.org/10.1161/JAHA.115.002433
    • de Ridder, I. R., Fransen, P. S. S., Beumer, D., Berkhemer, O. A., van den Berg, L. A., Wermer, M. J., Lingsma, H., van Zwam, W. H., Roos, Y. B., van Oostenbrugge, R. J., Majoie, C. B., van der Lugt, A., & Dippel, D. W. J. (2016). Is Intra-Arterial Treatment for Acute Ischemic Stroke Less Effective in Women than in Men?Interventional Neurology, 5(3-4), 174-178. https://doi.org/10.1159/000447331
    • Beumer, D., Mulder, M. J. H. L., Saiedie, G., Fonville, S., van Oostenbrugge, R. J., van Zwam, W., Homburg, P. J., van der Lugt, A., & Dippel, D. W. J. (2016). Occurence of intracranial large vessel occlusion in consecutive, non-referred patients with acute ischemic stroke. Neurovascular Imaging, 2, Article 11. https://doi.org/10.1186/s40809-016-0022-5
  • 2015
    • Broderick, J. P., Berkhemer, O. A., Palesch, Y. Y., Dippel, D. W. J., Foster, L. D., Roos, Y. B. W. E. M., van der Lugt, A., Tomsick, T. A., Majoie, C. B. L. M., van Zwam, W. H., Demchuk, A. M., van Oostenbrugge, R. J., Khatri, P., Lingsma, H. F., Hill, M. D., Roozenbeek, B., Jauch, E. C., Jovin, T. G., Yan, B., ... Simpson, K. N. (2015). Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke. Stroke, 46(12), 3416-3422. https://doi.org/10.1161/STROKEAHA.115.011397
    • Borst, J., Berkhemer, O. A., Roos, Y. B. W. E. M., van Bavel, E., van Zwam, W. H., van Oostenbrugge, R. J., van Walderveen, M. A. A., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Yoo, A. J., Marquering, H. A., & Majoie, C. B. L. M. (2015). Value of Computed Tomographic Perfusion-Based Patient Selection for Intra-Arterial Acute Ischemic Stroke Treatment. Stroke, 46(12), 3375-3382. https://doi.org/10.1161/STROKEAHA.115.010564
    • Zonneveld, T. P., Algra, A., Dippel, D. W. J., Kappelle, L. J., van Oostenbrugge, R. J., Roos, Y. B. W. E. M., Wermer, M. J., van der Worp, H. B., Nederkoorn, P. J., & Kruyt, N. D. (2015). The ThRombolysis in UnconTrolled Hypertension (TRUTH) protocol: an observational study on treatment strategy of elevated blood pressure in stroke patients eligible for IVT. BMC Neurology, 15(1), Article 241. https://doi.org/10.1186/s12883-015-0493-z
    • Mulder, M. J. H. L., van Oostenbrugge, R. J., & Dippel, D. W. J. (2015). Letter by Mulder et al Regarding Article, "2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association". Stroke, 46(11), E235-E235. https://doi.org/10.1161/STROKEAHA.115.010913
    • Loos, C. M. J., Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 10(9), Article e0137323. https://doi.org/10.1371/journal.pone.0137323
    • van Hoof, R. H. M., Hermeling, E., Truijman, M. T. B., van Oostenbrugge, R. J., Daemen, J. W. H., van der Geest, R. J., van Orshoven, N. P., Schreuder, A. H., Backes, W. H., Daemen, M. J. A. P., Wildberger, J. E., & Kooi, M. E. (2015). Phase-based vascular input function: Improved quantitative DCE-MRI of atherosclerotic plaques. Medical Physics, 42(8), 4619-4628. https://doi.org/10.1118/1.4924949
    • Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Ambulatory Arterial Stiffness Index Is Not Associated With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Lacunar Stroke Patients. Journal of Clinical Hypertension, 17(5), 352-356. https://doi.org/10.1111/jch.12504
    • van Bussel, F. C., Backes, W. H., Hofman, P. A., van Oostenbrugge, R. J., Kessels, A. G., van Boxtel, M. P., Schram, M. T., Stehouwer, C. D., Wildberger, J. E., & Jansen, J. F. (2015). On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes. Diabetes Care, 38(5), 876-882. https://doi.org/10.2337/dc14-2043
    • van den Berg, L. A., Koelman, D. L. H., Berkhemer, O. A., Rozeman, A. D., Fransen, P. S. S., Beumer, D., Dippel, D. W., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Brouwer, P. A., Jenniskens, S., Boiten, J., Nijeholt, G. A. L. A., Vos, J. A., Schonewille, W. J., Majoie, C. B. L. M., & Roos, Y. B. W. E. M. (2015). Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke. Stroke, 46(5), 1257-1262. https://doi.org/10.1161/STROKEAHA.115.008699
    • Dirks, M., Zonneveld, T. P., Dippel, D. W. J., Nederkoorn, P. J., van de Beek, D., van Oostenbrugge, R. J., & Kruyt, N. D. (2015). Elevated pretreatment blood pressure and IV thrombolysis in stroke. Neurology, 84(14), 1419-1425. https://doi.org/10.1212/WNL.0000000000001445
    • de Greef, B. T. A., Schreuder, F. H. B. M., Vlooswijk, M. C. G., Schreuder, A. H. C. M. L., Rooyer, F. A., van Oostenbrugge, R. J., & Rouhl, R. P. W. (2015). Early seizures after intracerebral hemorrhage predict drug-resistant epilepsy. Journal of Neurology, 262(3), 541-546. https://doi.org/10.1007/s00415-014-7592-4
    • Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2015). A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke. New England Journal of Medicine, 372(1), 11-20. https://doi.org/10.1056/NEJMoa1411587
    • Nederkoorn, P. J., van Dijk, E. J., Koudstaal, P. J., Luijckx, G.-J., van Oostenbrugge, R. J., Visser, M. C., Wermer, M. J. H., Ruigrok, Y. M., Algra, A., & Kappelle, L. J. (2015). The Dutch String-of-Pearls Stroke Study: Protocol of a large prospective multicenter genetic cohort study. International journal of stroke, 10(1), 120-122. https://doi.org/10.1111/ijs.12359
  • 2014
    • Truijman, M. T., de Rotte, A. A., Aaslid, R., van Dijk, A. C., Steinbuch, J., Liem, M. I., Schreuder, F. H., van der Steen, A. F., Daemen, M. J., van Oostenbrugge, R. J., Wildberger, J. E., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Kooi, M. E., & Mess, W. H. (2014). Intraplaque Hemorrhage, Fibrous Cap Status, and Microembolic Signals in Symptomatic Patients With Mild to Moderate Carotid Artery Stenosis: The Plaque At RISK Study. Stroke, 45(11), 3423-3426. https://doi.org/10.1161/STROKEAHA.114.006800
    • Fransen, P. S. S., Beumer, D., Berkhemer, O. A., van den Berg, L. A., Lingsma, H., van der Lugt, A., van Zwam, W. H., van Oostenbrugge, R. J., Roos, Y. B. W. E. M., Majoie, C. B., & Dippel, D. W. J. (2014). MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial. Trials, 15(1), Article 343. https://doi.org/10.1186/1745-6215-15-343
    • Uiterwijk, R., Huijts, M., Staals, J., Duits, A., Gronenschild, E., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds. Hypertension, 64(3), 653-657. https://doi.org/10.1161/HYPERTENSIONAHA.114.03621
    • Truijman, M. T., Kooi, M. E., van Dijk, A. C., de Rotte, A. A., van der Kolk, A. G., Liem, M. I., Schreuder, F. H., Boersma, E., Mess, W. H., van Oostenbrugge, R. J., Koudstaal, P. J., Kappelle, L. J., Nederkoorn, P. J., Nederveen, A. J., Hendrikse, J., van der Steen, A. F., Daemen, M. J., & van der Lugt, A. (2014). Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. International journal of stroke, 9(6), 747-754. https://doi.org/10.1111/ijs.12167
    • van Dooren, M., Staals, J., de Leeuw, P. W., Kroon, A. A., Henskens, L. H., & van Oostenbrugge, R. J. (2014). Progression of Brain Microbleeds in Essential Hypertensive Patients: A 2-Year Follow-up Study. American Journal of Hypertension, 27(8), 1045-1051. https://doi.org/10.1093/ajh/hpu032
    • Tijssen, M. P. M., Hofman, P. A. M., Stadler, A. A. R., van Zwam, W., de Graaf, R., van Oostenbrugge, R. J., Klotz, E., Wildberger, J. E., & Postma, A. A. (2014). The role of dual energy CT in differentiating between brain haemorrhage and contrast medium after mechanical revascularisation in acute ischaemic stroke. European Radiology, 24(4), 834-840. https://doi.org/10.1007/s00330-013-3073-x
    • Schols, A. M. R., Schreuder, F. H. B. M., van Raak, E. P. M., Schreuder, T. H. C. M. L., Rooyer, F. A., van Oostenbrugge, R. J., & Staals, J. (2014). Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands. Stroke, 45(1), 268-270. https://doi.org/10.1161/STROKEAHA.113.003003
    • Huijts, M., Duits, A., Staals, J., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease. Current Neurovascular Research, 11(2), 136-141. https://doi.org/10.2174/1567202611666140310102248
    • Vangheluwe, R., Postma - Jacobi, L., Ten Tusscher, M., Baijens - Leurs, L., & van Oostenbrugge, R. J. (2014). Post-traumatic Winking Induced by Extension of the Hand: A Case Report of a Novel Synkinesis. European Journal of Case Reports in Internal Medicine. https://doi.org/10.12890/2014_000112
    • van Buchem, M. A., Biessels, G. J., la Rocca, H. P. B., de Craen, A. J. M., van der Flier, W. M., Ikram, M. A., Kappelle, L. J., Koudstaal, P. J., Mooijaart, S. P., Niessen, W., van Oostenbrugge, R., de Roos, A., van Rossum, A. C., & Daemen, M. J. A. P. (2014). The Heart-Brain Connection: A Multidisciplinary Approach Targeting a Missing Link in the Pathophysiology of Vascular Cognitive Impairment. Journal of Alzheimer's Disease, 42, S443-S451. https://doi.org/10.3233/JAD-141542
  • 2013
    • Huijts, M., Duits, A., van Oostenbrugge, R. J., Kroon, A. A., de Leeuw, P. W., & Staals, J. (2013). Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients. Frontiers in Aging Neuroscience, 5(NOV), Article 72. https://doi.org/10.3389/fnagi.2013.00072
    • Klarenbeek, P., van Oostenbrugge, R. J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Ambulatory Blood Pressure in Patients With Lacunar Stroke Association With Total MRI Burden of Cerebral Small Vessel Disease. Stroke, 44(11), 2995-2999. https://doi.org/10.1161/STROKEAHA.113.002545
    • Vles, G. F., Soudant, D. L., Hoving, M. A., Vermeulen, R. J., Bonouvrie, L. A., van Oostenbrugge, R. J., & Vles, J. S. H. (2013). Long-term follow-up on continuous intrathecal Baclofen therapy in non-ambulant children with intractable spastic Cerebral Palsy. European Journal of Paediatric Neurology, 17(6), 639-644. https://doi.org/10.1016/j.ejpn.2013.06.003
    • van Overbeek, E. C., Staals, J., & van Oostenbrugge, R. J. (2013). Vitamin B12 and Progression of White Matter Lesions. A 2-Year Follow-Up Study in First-Ever Lacunar Stroke Patients. PLOS ONE, 8(10). https://doi.org/10.1371/journal.pone.0078100
    • MR CLEAN Investigators, & van Oostenbrugge, R. J. (2013). Automated Cerebral Infarct Volume Measurement in Follow-up Noncontrast CT Scans of Patients with Acute Ischemic Stroke. American Journal of Neuroradiology, 34(8), 1522-1527. https://doi.org/10.3174/ajnr.A3463
    • Wardlaw, J. M., Smith, E. E., Biessels, G. J., Cordonnier, C., Fazekas, F., Frayne, R., Lindley, R. I., O'Brien, J. T., Barkhof, F., Benavente, O. R., Black, S. E., Brayne, C., Breteler, M., Chabriat, H., DeCarli, C., de Leeuw, F.-E., Doubal, F., Duering, M., Fox, N. C., ... Dichgans, M. (2013). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurology, 12(8), 822-838. https://doi.org/10.1016/S1474-4422(13)70124-8
    • Huijts, M., van Oostenbrugge, R. J., Duits, A., Burkard, T., Muzzarelli, S., Maeder, M. T., Schindler, R., Pfisterer, M. E., & Brunner-La Rocca, H.-P. (2013). Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) randomized trial. European journal of heart failure, 15(6), 699-707. https://doi.org/10.1093/eurjhf/hft020
    • Kwee, R. M., van Oostenbrugge, R. J., Mess, W. H., Prins, M. H., van der Geest, R. J., Ter Berg, J. W., Franke, CL., Korten, A. G., Meems, B. J., van Engelshoven, J. M., Wildberger, J. E., & Kooi, M. E. (2013). MRI of carotid atherosclerosis to identify TIA and stroke patients who are at risk of a recurrence. Journal of Magnetic Resonance Imaging, 37(5), 1189-1194. https://doi.org/10.1002/jmri.23918
    • Klarenbeek, P., van Oostenbrugge, R. J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Higher Ambulatory Blood Pressure Relates to New Cerebral Microbleeds 2-Year Follow-Up Study in Lacunar Stroke Patients. Stroke, 44(4), 978-983. https://doi.org/10.1161/STROKEAHA.111.676619
    • Truijman, M. T., Kwee, R. M., van Hoof, R. H., Hermeling, E., van Oostenbrugge, R. J., Mess, W. H., Backes, W. H., Daemen, M. J., Bucerius, J., Wildberger, J. E., & Kooi, M. E. (2013). Combined 18F-FDG PET-CT and DCE-MRI to Assess Inflammation and Microvascularization in Atherosclerotic Plaques.Stroke, 44(12), 3568-3570. https://doi.org/10.1161/STROKEAHA.113.003140
    • Huijts, M., van Oostenbrugge, R. J., Rouhl, R. P., Menheere, P. P. C. A., & Duits, A. (2013). Effects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar stroke. International Psychogeriatrics, 25(3), 508-510. https://doi.org/10.1017/S1041610212001925
    • Klarenbeek, P., van Oostenbrugge, R. J., Lodder, J., Rouhl, R. P. W., Knottnerus, I. L. H., & Staals, J. (2013). Higher ambulatory blood pressure relates to enlarged Virchow-Robin spaces in first-ever lacunar stroke patients. Journal of Neurology, 260(1), 115-121. https://doi.org/10.1007/s00415-012-6598-z
    • Martens, R. J. H., Vink, H., van Oostenbrugge, R. J., & Staals, J. (2013). Sublingual Microvascular Glycocalyx Dimensions in Lacunar Stroke Patients. Cerebrovascular Diseases, 35(5), 451-454. https://doi.org/10.1159/000348854
  • 2012
    • Postma, A. A., Hofman, P. A. M., Stadler, A. A. R., van Oostenbrugge, R. J., Tijssen, M. P. M., & Wildberger, J. E. (2012). Dual-Energy CT of the Brain and Intracranial Vessels. American Journal of Roentgenology, 199(5), S26-S33. https://doi.org/10.2214/AJR.12.9115
    • Loos, C. M. J., Staals, J., Wardlaw, J. M., & van Oostenbrugge, R. J. (2012). Cavitation of Deep Lacunar Infarcts in Patients With First-Ever Lacunar Stroke A 2-Year Follow-Up Study With MR. Stroke, 43(8), 2245-U450. https://doi.org/10.1161/STROKEAHA.112.660076
    • Rouhl, R. P. W., Damoiseaux, J. G. M. C., Lodder, J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Tervaert, J. W. C., & van Oostenbrugge, R. J. (2012). Vascular inflammation in cerebral small vessel disease. Neurobiology of Aging, 33(8), 1800-1806. https://doi.org/10.1016/j.neurobiolaging.2011.04.008
    • Mees, S. M. D., Algra, A., Vandertop, W. P., van Kooten, F., Kuijsten, H. A. J. M., Boiten, J., van Oostenbrugge, R. J., Salman, R. A.-S., Lavados, P. M., Rinkel, G. J. E., & van den Bergh, W. M. (2012). Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet, 380(9836), 44-49. https://doi.org/10.1016/S0140-6736(12)60724-7
    • Dirks, M., Niessen, L. W., van Wijngaarden, J., Koudstaal, P. J., Franke, C. L., van Oostenbrugge, R. J., & Dippel, D. W. J. (2012). The effectiveness of thrombolysis with intravenous alteplase for acute ischemic stroke in daily practice. International journal of stroke, 7(4), 289-292. https://doi.org/10.1111/j.1747-4949.2011.00709.x
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