• 2016
    • Miglianico, M., Nicolaes, G. A. F., & Neumann, D. (2016). Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design. Journal of Medicinal Chemistry, 59(7), 2879-2893. https://doi.org/10.1021/acs.jmedchem.5b01201
    • Oligschläger, Y., Miglianico, M., Dahlmans, V. E., Rubio-Villena, C., Chanda, D., Adelaida Garcia-Gimeno, M., Coumans, W. A., Liu, Y., Voncken, J. W., Luiken, J. J. F. P., Glatz, J. F. C., Sanz, P., & Neumann, D. (2016). The interaction between AMPK beta 2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content. Biochemical Journal, 473(7), 937-947. https://doi.org/10.1042/BJ20151035
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2016). A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomechanics and modeling in mechanobiology, 15(2), 419-432. https://doi.org/10.1007/s10237-015-0699-4
    • Frusch, K. J. M., Houben, R., Schreuder, F. H. B. M., Postma - Jacobi, L., & Staals, J. (2016). Association between eye position on brain scan and hospital mortality in acute intracerebral hemorrhage. European Journal of Neurology, 23(4), 831-835. https://doi.org/10.1111/ene.12951
    • Maessen, D. E., Brouwers, O., Gaens, K. H., Wouters, K., Cleutjens, J. P., Janssen, B. J., Miyata, T., Stehouwer, C. D., & Schalkwijk, C. G. (2016). Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice. Diabetes, 65(4), 956-966. https://doi.org/10.2337/db15-1390
    • Kemerink, G. J., van Engelshoven, J., Simon, K. J., Kutterer, G., & Wildberger, J. E. (2016). Early X-ray workers: an effort to assess their numbers, risk, and most common (skin) affliction. Insights into Imaging, 7(2), 275-282. https://doi.org/10.1007/s13244-015-0457-2
    • Uiterwijk, R., Huijts, M., Staals, J., Rouhl, R. P. W., De Leeuw, P. W., Kroon, A. A., & Van Oostenbrugge, R. J. (2016). Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension. American Journal of Hypertension, 29(4), 464-469. https://doi.org/10.1093/ajh/hpv122
    • Mihl, C., Kok, M., Altintas, S., Kietselaer, B. L. J. H., Turek, J., Wildberger, J. E., & Das, M. (2016). Evaluation of individually body weight adapted contrast media injection in coronary CT-angiography. European Journal of Radiology, 85(4), 830-836. https://doi.org/10.1016/j.ejrad.2015.12.031
    • Kok, M., de Haan, M., Mihl, C., Eijsvoogel, N. G., Hendriks, B. M. F., Sailer, A. M., Derks, K., Schnerr, R. S., Schurink, G., Wildberger, J. E., & Das, M. (2016). Individualized CT Angiography Protocols for the Evaluation of the Aorta: A Feasibility Study. Journal of Vascular and Interventional Radiology, 27(4), 531-538. https://doi.org/10.1016/j.jvir.2016.01.009
    • Mahl, C., Egea, V., Megens, R. T. A., Pitsch, T., Santovito, D., Weber, C., & Ries, C. (2016). RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/beta-catenin signaling in human mesenchymal stem cells. Cellular and Molecular Life Sciences, 73(7), 1489-1501. https://doi.org/10.1007/s00018-015-2054-4
    • Broen, M. P. G., Marsman, V. A. M., Kuijf, M. L., Van Oostenbrugge, R. J., van Os, J., & Leentjens, A. F. G. (2016). Unraveling the Relationship between Motor Symptoms, Affective States and Contextual Factors in Parkinson's Disease: A Feasibility Study of the Experience Sampling Method. PLOS ONE, 11(3), Article e0151195. https://doi.org/10.1371/journal.pone.0151195
    • van Overbeek, E. C., Staals, J., Knottnerus, I. L. H., ten Cate, H., & van Oostenbrugge, R. J. (2016). Plasma tPA-Activity and Progression of Cerebral White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 11(3), Article e0150740. https://doi.org/10.1371/journal.pone.0150740
    • van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., Wildberger, J. E., & Jansen, J. F. A. (2016). Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements. Journal of Neuroendocrinology, 28(3), Article 12366. https://doi.org/10.1111/jne.12366
    • Berkhemer, O. A., Jansen, I. G. H., Beumer, D., Fransen, P. S. S., van den Berg, L. A., Yoo, A. J., Lingsma, H. F., Sprengers, M. E. S., Jenniskens, S. F. M., Lycklama a Nijeholt, G. J., van Walderveen, M. A. A., van den Berg, R., Bot, J. C. J., Beenen, L. F. M., Boers, A. M. M., Slump, C. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Dippel, D. W. J., ... Majoie, C. B. L. M. (2016). Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke. Stroke, 47(3), 768-776. https://doi.org/10.1161/STROKEAHA.115.011788
    • Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163. https://doi.org/10.1016/j.molmet.2015.12.005
    • Gerdes, N., Seijkens, T., Lievens, D., Kuijpers, M. J. E., Winkels, H., Projahn, D., Hartwig, H., Beckers, L., Megens, R. T. A., Boon, L., Noelle, R. J., Soehnlein, O., Heemskerk, J. W. M., Weber, C., & Lutgens, E. (2016). Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes. Arteriosclerosis Thrombosis and Vascular Biology, 36(3), 482-490. https://doi.org/10.1161/ATVBAHA.115.307074
    • de Bruin, R. G., Shiue, L., Prins, J., de Boer, H. C., Singh, A., Fagg, W. S., van Gils, J. M., Duijs, J. M. G. J., Katzman, S., Kraaijeveld, A. O., Bohringer, S., Leung, W. Y., Kielbasa, S. M., Donahue, J. P., van der Zande, P. H. J., Sijbom, R., van Alem, C. M. A., Bot, I., van Kooten, C., ... van der Veer, E. P. (2016). Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. Nature Communications, 7, Article 10846. https://doi.org/10.1038/ncomms10846
    • Santos, E. M. M., Marquering, H. A., den Blanken, M. D., Berkhemer, O. A., Boers, A. M. M., Yoo, A. J., Beenen, L. F., Treurniet, K. M., Wismans, C., van Noort, K., Lingsma, H. F., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Niessen, W. J., & Majoie, C. B. (2016). Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke. Stroke, 47(3), 732-741. https://doi.org/10.1161/STROKEAHA.115.011187
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2016). Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis. Age, 38(1), Article 17. https://doi.org/10.1007/s11357-016-9878-1
    • Hartmann, P., Zhou, Z., Natarelli, L., Wei, Y., Nazari-Jahantigh, M., Zhu, M., Grommes, J., Steffens, S., Weber, C., & Schober, A. (2016). Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nature Communications, 7, Article 10521. https://doi.org/10.1038/ncomms10521
    • van Elmpt, W., Zegers, K., Reymen, B., Even, A. J. G., Dingemans, A.-M. C., Öllers, M., Wildberger, J. E., Mottaghy, F. M., Das, M., Troost, E. G. C., & Lambin, P. (2016). Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion. European Journal of Nuclear Medicine and Molecular Imaging, 43(2), 240-248. https://doi.org/10.1007/s00259-015-3169-4
    • MR CLEAN Investigators, van Zwam, W., & van Oostenbrugge, R. J. (2016). Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke. Neuroradiology, 58(2), 133-139. https://doi.org/10.1007/s00234-015-1607-4
    • Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012
    • Steinbuch, J., Hoeks, A. P. G., Hermeling, E., Truijman, M. T. B., Schreuder, F. H. B. M., & Mess, W. (2016). Standard B-Mode Ultrasound Measures Local Carotid Artery Characteristics as Reliably as Radiofrequency Phase Tracking in Symptomatic Carotid Artery Patients. Ultrasound in Medicine and Biology, 42(2), 586-595. https://doi.org/10.1016/j.ultrasmedbio.2015.07.030
    • Marsch, E., Theelen, T., Janssen, B. J., Briedé, J. J., Haenen, G. R., Senden, J., van Loon, L. J., Poeze - van Bokhoven, M., Bierau, J., Gijbels, M. J., Daemen, M. J., & Sluimer, J. (2016). The effect of prolonged dietary nitrate supplementation on atherosclerosis development. Atherosclerosis, 245, 212-221. https://doi.org/10.1016/j.atherosclerosis.2015.11.031
    • Fransen, P. S. S., Berkhemer, O. A., Lingsma, H. F., Beumer, D., van den Berg, L. A., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2016). Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke A Randomized Clinical Trial. JAMA Neurology, 73(2), 190-196. https://doi.org/10.1001/jamaneurol.2015.3886
    • MR CLEAN Investigators, van Oostenbrugge, R. J., & van Zwam, W. (2016). Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke. PLOS ONE, 11(1), Article e0145641. https://doi.org/10.1371/journal.pone.0145641
    • Schrauwen-Hinderling, V. B., Kooi, E., & Schrauwen, P. (2016). Mitochondrial Function and Diabetes: Consequences for Skeletal and Cardiac Muscle Metabolism. Antioxidants & Redox Signaling, 24(1), 39-51. https://doi.org/10.1089/ars.2015.6291
    • Paulis, L., Foulquier, S., Namsolleck, P., Recarti, C., Steckelings, U. M., & Unger, T. (2016). Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders. Drugs, 76(1), 1-12. https://doi.org/10.1007/s40265-015-0509-4
    • Wahlgren, N., Moreira, T., Michel, P., Steiner, T., Jansen, O., Cognard, C., Mattle, H. P., van Zwam, W., Holmin, S., Tatlisumak, T., Petersson, J., Caso, V., Hacke, W., Mazighi, M., Arnold, M., Fischer, U., Szikora, I., Pierot, L., Fiehler, J., ... Lees, K. R. (2016). Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN. International journal of stroke, 11(1), 134-147. https://doi.org/10.1177/1747493015609778
    • Bouwmans, A. E. P., Leentjens, A. F. G., Mess, W. H., & Weber, W. E. J. (2016). Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson's Disease, 2016, Article 4058580. https://doi.org/10.1155/2016/4058580
    • Haeren, R. H. L., van de Ven, S. E. M., van Zandvoort, M. A. M. J., Vink, H., van Overbeeke, J. J., Hoogland, G., & Rijkers, K. (2016). Assessment and Imaging of the Cerebrovascular Glycocalyx. Current Neurovascular Research, 13(3), 249-260. https://doi.org/10.2174/1567202613666160504104434
    • Jamasbi, J., Megens, R. T. A., Bianchini, M., Uhland, K., Münch, G., Ungerer, M., Sherman, S., Faussner, A., Brandl, R., John, C., Buchner, J., Weber, C., Lorenz, R., Elia, N., & Siess, W. (2016). Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation. JACC: Basic to Translational Science, 1(3), 131 – 142. https://doi.org/10.1016/j.jacbts.2016.03.008
    • Landry, G., Gaudreault, M., van Elmpt, W., Wildberger, J. E., & Verhaegen, F. (2016). Improved dose calculation accuracy for low energy brachytherapy by optimizing dual energy CT imaging protocols for noise reduction using sinogram affirmed iterative reconstruction. Zeitschrift für Medizinische Physik, 26(1), 75-87. https://doi.org/10.1016/j.zemedi.2015.09.001
    • Hendriks, B. M. F., Kok, M., Mihl, C., Bekkers, B., Wildberger, J. E., & Das, M. (2016). Individually tailored contrast enhancement in CT pulmonary angiography. British Journal of Radiology, 89(1061), Article 20150850. https://doi.org/10.1259/bjr.20150850
    • de Ridder, I. R., Fransen, P. S. S., Beumer, D., Berkhemer, O. A., van den Berg, L. A., Wermer, M. J., Lingsma, H., van Zwam, W. H., Roos, Y. B., van Oostenbrugge, R. J., Majoie, C. B., van der Lugt, A., & Dippel, D. W. J. (2016). Is Intra-Arterial Treatment for Acute Ischemic Stroke Less Effective in Women than in Men?Interventional Neurology, 5(3-4), 174-178. https://doi.org/10.1159/000447331
    • Beumer, D., Mulder, M. J. H. L., Saiedie, G., Fonville, S., van Oostenbrugge, R. J., van Zwam, W., Homburg, P. J., van der Lugt, A., & Dippel, D. W. J. (2016). Occurence of intracranial large vessel occlusion in consecutive, non-referred patients with acute ischemic stroke. Neurovascular Imaging, 2, Article 11. https://doi.org/10.1186/s40809-016-0022-5
    • Altintas, S., Cardinaels, E., Versteylen, M. O., Joosen, I. A., Seifert, H., Wildberger, J. E., Crijns, H. J., Nelemans, P. J., van Dieijen - Visser, M. P., Mingels, A. M. A., Das, M., & Kietselaer, B. L. (2016). Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide. Journal of Cardiovascular Computed Tomography, 10(1), 82-88. https://doi.org/10.1016/j.jcct.2015.10.001
  • 2015
    • Alard, J.-E., Ortega-Gomez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R. T. A., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., Ng, J., Ippel, H., Suylen, D., Hinkel, R., Blanchet, X., Gaillard, F., D'Amico, M., von Hundelshausen, P., Zarbock, A., ... Soehnlein, O. (2015). Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Science Translational Medicine, 7(317), Article 317ra196. https://doi.org/10.1126/scitranslmed.aad5330
    • Kok, M., Mihl, C., Seehofnerova, A., Turek, J., Jost, G., Pietsch, H., Haberland, U., Wildberger, J. E., & Das, M. (2015). Automated Tube Voltage Selection for Radiation Dose Reduction in CT Angiography Using Different Contrast Media Concentrations and a Constant Iodine Delivery Rate. American Journal of Roentgenology, 205(6), 1332-1338. https://doi.org/10.2214/AJR.14.13957
    • Sailer, A. M., van Zwam, W. H., Wildberger, J. E., & Grutters, J. P. C. (2015). Cost-effectiveness modelling in diagnostic imaging: a stepwise approach. European Radiology, 25(12), 3629-3637. https://doi.org/10.1007/s00330-015-3770-8
    • Lalji, U. C., Wildberger, J. E., Hausen, A. Z., Bendek, M., Dingemans, A.-M. C., Hochstenbag, M., & Das, M. (2015). CT-Guided Percutaneous Transthoracic Needle Biopsies Using 10G Large-Core Needles: Initial Experience. Cardiovascular and Interventional Radiology, 38(6), 1603-1610. https://doi.org/10.1007/s00270-015-1098-z
    • Akhtar, S., Hartmann, P., Karshovska, E., Rinderknecht, F.-A., Subramanian, P., Gremse, F., Grommes, J., Jacobs, M., Kiessling, F., Weber, C., Steffens, S., & Schober, A. (2015). Endothelial Hypoxia-Inducible Factor-1 alpha Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a. Hypertension, 66(6), 1220-1226. https://doi.org/10.1161/HYPERTENSIONAHA.115.05886
    • Broderick, J. P., Berkhemer, O. A., Palesch, Y. Y., Dippel, D. W. J., Foster, L. D., Roos, Y. B. W. E. M., van der Lugt, A., Tomsick, T. A., Majoie, C. B. L. M., van Zwam, W. H., Demchuk, A. M., van Oostenbrugge, R. J., Khatri, P., Lingsma, H. F., Hill, M. D., Roozenbeek, B., Jauch, E. C., Jovin, T. G., Yan, B., ... Simpson, K. N. (2015). Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke. Stroke, 46(12), 3416-3422. https://doi.org/10.1161/STROKEAHA.115.011397
    • Borst, J., Berkhemer, O. A., Roos, Y. B. W. E. M., van Bavel, E., van Zwam, W. H., van Oostenbrugge, R. J., van Walderveen, M. A. A., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Yoo, A. J., Marquering, H. A., & Majoie, C. B. L. M. (2015). Value of Computed Tomographic Perfusion-Based Patient Selection for Intra-Arterial Acute Ischemic Stroke Treatment. Stroke, 46(12), 3375-3382. https://doi.org/10.1161/STROKEAHA.115.010564
    • Zonneveld, T. P., Algra, A., Dippel, D. W. J., Kappelle, L. J., van Oostenbrugge, R. J., Roos, Y. B. W. E. M., Wermer, M. J., van der Worp, H. B., Nederkoorn, P. J., & Kruyt, N. D. (2015). The ThRombolysis in UnconTrolled Hypertension (TRUTH) protocol: an observational study on treatment strategy of elevated blood pressure in stroke patients eligible for IVT. BMC Neurology, 15(1), Article 241. https://doi.org/10.1186/s12883-015-0493-z
    • Hazebroek, M. R., Kemna, M. J., Schalla, S., Sanders-van Wijk, S., Gerretsen, S. C., Dennert, R., Merken, J., Kuznetsova, T., Staessen, J. A., Brunner-La Rocca, H. P., van Paassen, P., Tervaert, J. W. C., & Heymans, S. (2015). Prevalence and prognostic relevance of cardiac involvement in ANCA-associated vasculitis: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis. International Journal of Cardiology, 199, 170-179. https://doi.org/10.1016/j.ijcard.2015.06.087