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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Stephane Heymans

Professor

Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.

Website www.hfresearch.eu

Stephane-heymans

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2020
    • Verdonschot, J. A. J., Wang, P., Van Bilsen, M., Hazebroek, M. R., Merken, J. J., Vanhoutte, E. K., Henkens, M. T. H. M., Van Den Wijngaard, A., Glatz, J. F. C., Krapels, I. P. C., Brunner, H. G., Heymans, S. R. B., & Bierau, J. (2020). Metabolic Profiling Associates with Disease Severity in Nonischemic Dilated Cardiomyopathy. Journal of Cardiac Failure, 26(3), 212-222. https://doi.org/10.1016/j.cardfail.2019.09.004
    • Stienen, S., Ferreira, J. P., Kobayashi, M., Preud'homme, G., Dobre, D., Machu, J.-L., Duarte, K., Bresso, E., Devignes, M.-D., Lopez, N., Girerd, N., Aakhus, S., Ambrosio, G., Brunner-La Rocca, H.-P., Fontes-Carvalho, R., Fraser, A. G., Van Heerebeek, L., Heymans, S., De Keulenaer, G., ... Rossignol, P. (2020). Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure). Biomarkers, 25(2), 201-211. https://doi.org/10.1080/1354750X.2020.1727015
    • Verdonschot, J. A. J., Robinson, E. L., James, K. N., Mohamed, M. W., Claes, G. R. F., Casas, K., Vanhoutte, E. K., Hazebroek, M. R., Kringlen, G., Pasierb, M. M., van den Wijngaard, A., Glatz, J. F. C., Heymans, S. R. B., Krapels, I. P. C., Nahas, S., Brunner, H. G., & Szklarczyk, R. (2020). Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers. Molecular genetics & genomic medicine, 8(2), Article e1049. https://doi.org/10.1002/mgg3.1049
    • Verdonschot, J. A. J., Merken, J. J., Brunner-La Rocca, H.-P., Hazebroek, M. R., Eurlings, C. G. M. J., Thijssen, E., Wang, P., Weerts, J., van Empel, V., Schummers, G., Schreckenberg, M., van den Wijngaard, A., Lumens, J., Brunner, H. G., Heymans, S. R. B., Krapels, I. P. C., & Knackstedt, C. (2020). Value of Speckle Tracking-Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy. JACC-Cardiovascular Imaging, 13(2), 549-558. https://doi.org/10.1016/j.jcmg.2019.02.032
    • Gomes, C. P. C., Schroen, B., Kuster, G. M., Robinson, E. L., Ford, K., Squire, I. B., Heymans, S., Martelli, F., Emanueli, C., Devaux, Y., & EU-CardioRNA COST Action (CA17129) (2020). Regulatory RNAs in Heart Failure. Circulation, 141(4), 313-328. https://doi.org/10.1161/CIRCULATIONAHA.119.042474
    • Simmonds, S. J., Cuijpers, I., Heymans, S., & Jones, E. A. V. (2020). Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding. Cells, 9(1), Article 242. https://doi.org/10.3390/cells9010242
    • Azodi, M., Kamps, R., Heymans, S., & Robinson, E. L. (2020). The Missing "lnc" between Genetics and Cardiac Disease. Non-coding RNA, 6(1), Article 3. https://doi.org/10.3390/ncrna6010003
    • Bertero, E., Sequeira, V., Heymans, S., & Maack, C. (2020). Response to 'The possible role of insulin and glucagon in patients with heart failure and Type 2 diabetes'. European Heart Journal, 41(2), 326-327. https://doi.org/10.1093/eurheartj/ehz243
    • Ferreira, J. P., Pizard, A., Machu, J.-L., Bresso, E., Brunner-La Rocca, H.-P., Girerd, N., Leroy, C., Gonzalez, A., Diez, J., Heymans, S., Devignes, M.-D., Rossignol, P., Zannad, F., & FIBRO-TARGETS investigators (2020). Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses. Clinical research in cardiology, 109(1), 22-33. https://doi.org/10.1007/s00392-019-01480-4
  • 2019
    • Lewalle, A., Land, S., Merken, J. J., Raafs, A., Sepulveda, P., Heymans, S., Kleinjans, J., & Niederer, S. A. (2019). Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure. Biophysical Journal, 117(12), 2337-2348. https://doi.org/10.1016/j.bpj.2019.07.033
    • Maack, C., Eschenhagen, T., Hamdani, N., Heinzel, F. R., Lyon, A. R., Manstein, D. J., Metzger, J., Papp, Z., Tocchetti, C. G., Yilmaz, M. B., Anker, S. D., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Carrier, L., Chlopicki, S., Cleland, J. G., de Boer, R. A., Dietl, A., ... Mebazaa, A. (2019). Treatments targeting inotropy. European Heart Journal, 40(44), 3626-3644. https://doi.org/10.1093/eurheartj/ehy600
    • Iborra-Egea, O., Santiago-Vacas, E., Yurista, S. R., Lupón, J., Packer, M., Heymans, S., Zannad, F., Butler, J., Pascual-Figal, D., Lax, A., Núñez, J., de Boer, R. A., & Bayés-Genís, A. (2019). Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes. JACC: Basic to Translational Science, 4(7), 831-840. https://doi.org/10.1016/j.jacbts.2019.07.010
    • Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J.-S., Konstam, M., Lee, R. T., ... De Keulenaer, G. (2019). The continuous heart failure spectrum: moving beyond an ejection fraction classification. European Heart Journal, 40(26), 2155-2163. https://doi.org/10.1093/eurheartj/ehz158
    • Bauersachs, J., Koenig, T., van der Meer, P., Petrie, M. C., Hilfiker-Kleiner, D., Mbakwem, A., Hamdan, R., Jackson, A. M., Forsyth, P., de Boer, R. A., Mueller, C., Lyon, A. R., Lund, L. H., Piepoli, M. F., Heymans, S., Chioncel, O., Anker, S. D., Ponikowski, P., Seferovic, P. M., ... Sliwa, K. (2019). Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. European journal of heart failure, 21(7), 827-843. https://doi.org/10.1002/ejhf.1493
    • Verdonschot, J. A. J., Hazebroek, M. R., Ware, J. S., Prasad, S. K., & Heymans, S. R. B. (2019). Role of Targeted Therapy in Dilated Cardiomyopathy: The Challenging Road Toward a Personalized Approach. Journal of the American Heart Association, 8(11), Article 012514. https://doi.org/10.1161/JAHA.119.012514
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), Article 31. https://doi.org/10.3390/ncrna5020031
    • Ferreira, J. P., Verdonschot, J., Collier, T., Wang, P., Pizard, A., Bar, C., Bjorkman, J., Boccanelli, A., Butler, J., Clark, A., Cleland, J. G., Delles, C., Diez, J., Girerd, N., Gonzalez, A., Hazebroek, M., Huby, A.-C., Jukema, W., Latini, R., ... Zannad, F. (2019). Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure The HOMAGE Study. Circulation-Heart Failure, 12(5), Article 005897. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005897
    • Verjans, R., Derks, W. J. A., Korn, K., Soennichsen, B., van Leeuwen, R. E. W., Schroen, B., van Bilsen, M., & Heymans, S. (2019). Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure. Scientific Reports, 9(1), Article 6055. https://doi.org/10.1038/s41598-019-41491-9
    • Deckx, S., Johnson, D. M., Rienks, M., Carai, P., Van Deel, E., Van der Velden, J., Sipido, K. R., Heymans, S., & Papageorgiou, A.-P. (2019). Extracellular SPARC increases cardiomyocyte contraction during health and disease. PLOS ONE, 14(4), Article 0209534. https://doi.org/10.1371/journal.pone.0209534
    • Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M., & Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
    • de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X.-J., Ford, P., Heinzel, F. R., Lipson, K. E., McDonagh, T., Lopez-Andres, N., Lunde, I. G., Lyon, A. R., Pollesello, P., Prasad, S. K., Tocchetti, C. G., Mayr, M., Sluijter, J. P. G., ... Heymans, S. (2019). Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. European journal of heart failure, 21(3), 272-285. https://doi.org/10.1002/ejhf.1406
    • Verdonschot, J. A. J., Cooper, L. T., & Heymans, S. R. B. (2019). Parvovirus B19 in Dilated Cardiomyopathy: There Is More Than Meets the Eye. Journal of Cardiac Failure, 25(1), 64-66. https://doi.org/10.1016/j.cardfail.2018.11.017
  • 2018
    • Maack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J.-S., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J., Bayes-Genis, A., Brutsaert, D., Bugger, H., Clarke, K., Cosentino, F., De Keulenaer, G., Dei Cas, A., Gonzalez, A., Huelsmann, M., ... Heymans, S. (2018). Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology. European Heart Journal, 39(48), 4243–4254. https://doi.org/10.1093/eurheartj/ehy596
    • Steklov, M., Pandolf, S., Baietti, M. F., Batiuk, A., Carai, P., Najm, P., Zhang, M., Jang, H., Renzi, F., Cai, Y., Asbagh, L. A., Pastor, T., De Troyer, M., Simicek, M., Radaelli, E., Brems, H., Legius, E., Tavernier, J., Gevaert, K., ... Sablina, A. A. (2018). Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. Science, 362(6419), 1177-1182. https://doi.org/10.1126/science.aap7607
    • Rienks, M., Carai, P., van Teeffelen, J., Eskens, B., Verhesen, W., Hemmeryckx, B., Johnson, D. M., van Leeuwen, R., Jones, E. A., Heymans, S., & Papageorgiou, A.-P. (2018). SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis. Matrix Biology, 74, 21-34. https://doi.org/10.1016/j.matbio.2018.04.015
    • Verdonschot, J. A. J., Hazebroek, M. R., Wang, P., Sanders-van Wijk, S., Merken, J. J., Adriaansen, Y. A., van den Wijngaard, A., Krapels, I. P. C., Brunner-La Rocca, H.-P., Brunner, H. G., & Heymans, S. R. B. (2018). Clinical Phenotype and Genotype Associations With Improvement in Left Ventricular Function in Dilated Cardiomyopathy. Circulation-Heart Failure, 11(11), Article 005220. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005220
    • Merken, J., Brunner-La Rocca, H.-P., Weerts, J., Verdonschot, J., Hazebroek, M., Schummers, G., Schreckenberg, M., Lumens, J., Heymans, S., & Knackstedt, C. (2018). Heart Failure With Recovered Ejection Fraction. Journal of the American College of Cardiology, 72(13), 1556-1557. https://doi.org/10.1016/j.jacc.2018.06.070
    • Vasques-Novoa, F., Laundos, T. L., Cerqueira, R. J., Quina-Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonca, L., Goncalves, F., Reguenga, C., Verhesen, W., Carneiro, F., Paiva, J. A., Schroen, B., Castro-Chaves, P., Pinto-do-O, P., Nascimento, D. S., Heymans, S., Leite-Moreira, A. F., & Roncon-Albuquerque, R. (2018). MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. Critical Care Medicine, 46(9), E945-E954. https://doi.org/10.1097/CCM.0000000000003296
    • Caolo, V., Roblain, Q., Lecomte, J., Carai, P., Peters, L., Cuijpers, I., Robinson, E. L., Derks, K., Sergeys, J., Noel, A., Jones, E. A. V., Moons, L., & Heymans, S. (2018). Resistance to retinopathy development in obese, diabetic and hypertensive ZSF1 rats: an exciting model to identify protective genes. Scientific Reports, 8(1), Article 11922. https://doi.org/10.1038/s41598-018-29812-w
    • Bondue, A., Arbustini, E., Bianco, A., Ciccarelli, M., Dawson, D., De Rosa, M., Hamdani, N., Hilfiker-Kleiner, D., Meder, B., Leite-Moreira, A. F., Thum, T., Tocchetti, C. G., Varricchi, G., Van der Velden, J., Walsh, R., & Heymans, S. (2018). Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1287-1303. https://doi.org/10.1093/cvr/cvy122
    • van der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J.-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147
    • Poller, W., Dimmeler, S., Heymans, S., Zeller, T., Haas, J., Karakas, M., Leistner, D.-M., Jakob, P., Nakagawa, S., Blankenberg, S., Engelhardt, S., Thum, T., Weber, C., Meder, B., Hajjar, R., & Landmesser, U. (2018). Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives. European Heart Journal, 39(29), 2704–2716. https://doi.org/10.1093/eurheartj/ehx165
    • Fiedler, J., Baker, A. H., Dimmeler, S., Heymans, S., Mayr, M., & Thum, T. (2018). Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1281-1286. https://doi.org/10.1093/cvr/cvy121
    • Bauersachs, J., & Heymans, S. (2018). Scientific updates on the interaction of genes, epigenetics, and multicellularity in cardiovascular diseases: the Working Group of Myocardial Function of the ESC. Cardiovascular Research, 114(10), 1271-1272. https://doi.org/10.1093/cvr/cvy149
    • Suthahar, N., Meijers, W. C., Ho, J. E., Gansevoort, R. T., Voors, A. A., van der Meer, P., Bakker, S. J. L., Heymans, S., van Empel, V., Schroen, B., van der Harst, P., van Veldhuisen, D. J., & de Boer, R. A. (2018). Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population. European journal of heart failure, 20(8), 1205-1214. https://doi.org/10.1002/ejhf.1209
    • Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P., & van Bilsen, M. (2018). NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(8), 2579-2589. https://doi.org/10.1016/j.bbadis.2018.04.022
    • De Ruysscher, D., Dingemans, A.-M., Vooijs, M., & Heymans, S. (2018). PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?Journal of Thoracic Oncology, 13(4), 478-479. https://doi.org/10.1016/j.jtho.2018.02.008
    • Loebel, M., Holzhauser, L., Hartwig, J. A., Shukla, P. C., Savvatis, K., Jenke, A., Gast, M., Escher, F., Becker, S. C., Bauer, S., Stroux, A., Beling, A., Kespohl, M., Pinkert, S., Fechner, H., Kuehl, U., Lassner, D., Poller, W., Schultheiss, H.-P., ... Skurk, C. (2018). The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance inmyocarditis. European Heart Journal, 39(10), 876-887. https://doi.org/10.1093/eurheartj/ehx624
    • Verdonschot, J. A. J., Hazebroek, M. R., Derks, K. W. J., Aizpurua, A. B., Merken, J. J., Wang, P., Bierau, J., van den Wijngaard, A., Schalla, S. M., Hamid, M. A. A., van Bilsen, M., van Empel, V. P. M., Knackstedt, C., Brunner-La Rocca, H.-P., Brunner, H. G., Krapels, I. P. C., & Heymans, S. R. B. (2018). Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. European Heart Journal, 39(10), 864-873. https://doi.org/10.1093/eurheartj/ehx808
    • Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A.-P., & Heymans, S. (2018). Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. Matrix Biology, 66, 110-124. https://doi.org/10.1016/j.matbio.2017.09.002
    • Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., & Heymans, S. (2018). Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. Circulation-Heart Failure, 11(3), Article e004682 . https://doi.org/10.1161/CIRCHEARTFAILURE.117.004682
    • Frantz, S., Falcao-Pires, I., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G., & Heymans, S. (2018). The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. European journal of heart failure, 20(3), 445-459. https://doi.org/10.1002/ejhf.1138
    • Lourenco, A. P., Leite-Moreira, A. F., Balligand, J.-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcao-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L., & Heymans, S. (2018). An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure, 20(2), 216-227. https://doi.org/10.1002/ejhf.1059
    • Merken, J., Hazebroek, M., Van Paassen, P., Verdonschot, J., Van Empel, V., Knackstedt, C., Hamid, M. A., Seiler, M., Kolb, J., Hoermann, P., Ensinger, C., Brunner-La Rocca, H.-P., Poelzl, G., & Heymans, S. (2018). Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy. Circulation-Heart Failure, 11(2), Article 004228. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004228
    • Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288. https://doi.org/10.1161/HYPERTENSIONAHA.117.10094
    • Ferreira, J. P., Machu, J.-L., Girerd, N., Jaisser, F., Thum, T., Butler, J., Gonzalez, A., Diez, J., Heymans, S., McDonald, K., Gyongyosi, M., Firat, H., Rossignol, P., Pizard, A., & Zannad, F. (2018). Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. Esc heart failure, 5(1), 139-148. https://doi.org/10.1002/ehf2.12218
    • Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., ... Kleinjans, J. (2018). A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity. Archives of Toxicology, 92(1), 553-555. https://doi.org/10.1007/s00204-017-2041-7
    • Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029
  • 2017
    • van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7(1), Article 16042. https://doi.org/10.1038/s41598-017-16201-y
    • Afsar, B., Rossignol, P., van Heerebeek, L., Paulus, W. J., Damman, K., Heymans, S., van Empel, V., Sag, A., Maisel, A., & Kanbay, M. (2017). Heart failure with preserved ejection fraction: a nephrologist-directed primer. Heart Failure Reviews, 22(6), 765-773. https://doi.org/10.1007/s10741-017-9619-2
Overview