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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Stephane Heymans

Professor

Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.

Website www.hfresearch.eu

Stephane-heymans

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2017
    • Riemersma, M., Hazebroek, M. R., Helderman-van den Enden, A. T. J. M., Salomons, G. S., Ferdinandusse, S., Brouwers, M. C. G. J., van der Ploeg, L., Heymans, S., Glatz, J. F. C., van den Wijngaard, A., Krapels, I. P. C., Bierau, J., & Brunner, H. G. (2017). Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. European Journal of Human Genetics, 25(11), 1195-1201. https://doi.org/10.1038/ejhg.2017.127
    • van Bilsen, M., Patel, H. C., Bauersachs, J., Boehm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., ... Lyon, A. R. (2017). The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 19(11), 1361-1378. https://doi.org/10.1002/ejhf.921
    • Caforio, A. L. P., Adler, Y., Agostini, C., Allanore, Y., Anastasakis, A., Arad, M., Boehm, M., Charron, P., Elliott, P. M., Eriksson, U., Felix, S. B., Garcia-Pavia, P., Hachulla, E., Heymans, S., Imazio, M., Klingel, K., Marcolongo, R., Cerinic, M. M., Pantazis, A., ... Linhart, A. (2017). Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. European Heart Journal, 38(35), 2649-2662. https://doi.org/10.1093/eurheartj/ehx321
    • Heggermont, W. A., Papageorgiou, A.-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A.-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., ... Heymans, S. (2017). Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Circulation, 136(8), 747-761. https://doi.org/10.1161/CIRCULATIONAHA.116.024171
    • Rienks, M., Carai, P., Bitsch, N., Schellings, M., Vanhaverbeke, M., Verjans, J., Cuijpers, I., Heymans, S., & Papageorgiou, A. (2017). Sema3A promotes the resolution of cardiac inflammation after myocardial infarction. Basic Research in Cardiology, 112(4), Article 42. https://doi.org/10.1007/s00395-017-0630-5
    • Woudstra, L., Biesbroek, P. S., Emmens, R. W., Heymans, S., Juffermans, L. J., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2017). Lymphocytic myocarditis occurs with myocardial infarction and coincides with increased inflammation, hemorrhage and instability in coronary artery atherosclerotic plaques. International Journal of Cardiology, 232, 53-62. https://doi.org/10.1016/j.ijcard.2017.01.052
    • Rienks, M., Papageorgiou, A., Wouters, K., Verhesen, W., van Leeuwen, R., Carai, P., Summer, G., Westermann, D., & Heymans, S. (2017). A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis. Cellular and Molecular Life Sciences, 74(8), 1511-1525. https://doi.org/10.1007/s00018-016-2423-7
    • Woudstra, L., Biesbroek, P. S., Emmens, R. W., Heymans, S., Juffermans, L. J., van der Wal, A. C., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2017). CD45 is a more sensitive marker than CD3 to diagnose lymphocytic myocarditis in the endomyocardiurn. Human Pathology, 62, 83-90. https://doi.org/10.1016/j.humpath.2016.11.006
    • Smilde, B. J., Woudstra, L., Hing, G. F., Wouters, D., Zeerleder, S., Murk, J.-L., van Ham, M., Heymans, S., Juffermans, L. J. M., van Rossum, A. C., Niessen, H. W. M., Krijnen, P. A. J., & Emmens, R. W. (2017). Reply to the letter to the editor "Is colchicine really harmful in viral myocarditis?". International Journal of Cardiology, 229, 43-43. https://doi.org/10.1016/j.ijcard.2016.11.292
    • Knackstedt, C., Heymans, S., & Brunner-La Rocca, H.-P. (2017). ICD Implantation in Patients with Nonischemic Heart Failure. New England Journal of Medicine, 376(1), 91-92. https://doi.org/10.1056/NEJMc1614441
  • 2016
    • Heggermont, W. A., Papageorgiou, A.-P., Heymans, S., & van Bilsen, M. (2016). Metabolic support for the heart: complementary therapy for heart failure?European journal of heart failure, 18(12), 1420-1429. https://doi.org/10.1002/ejhf.678
    • Verdonschot, J., Hazebroek, M., Merken, J., Debing, Y., Dennert, R., Brunner-La Rocca, H., & Heymans, S. (2016). Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature. European journal of heart failure, 18(12), 1430-1441. https://doi.org/10.1002/ejhf.665
    • Heymans, S., Eriksson, U., Lehtonen, J., & Cooper, L. T. . J. (2016). The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy. Journal of the American College of Cardiology, 68(21), 2348-2364. https://doi.org/10.1016/j.jacc.2016.09.937
    • Ferreira, J. P., Girerd, N., Pellicori, P., Duarte, K., Girerd, S., Pfeffer, M. A., McMurray, J. J. V., Pitt, B., Dickstein, K., Jacobs, L., Staessen, J. A., Butler, J., Latini, R., Masson, S., Mebazaa, A., Brunner-La Rocca, H., Delles, C., Heymans, S., Sattar, N., ... Rossignol, P. (2016). Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine, 14(1), Article 181. https://doi.org/10.1186/s12916-016-0731-2
    • Hensgens, K., Merken, J., Hazebroek, M., & Heymans, S. R. B. (2016). Chronic Q fever leads to dilated cardiomyopathy in a 48-year-old male. International Journal of Cardiology, 222, 705-706. https://doi.org/10.1016/j.ijcard.2016.08.024
    • Summer, G., Kelder, T., Radonjic, M., van Bilsen, M., Wopereis, S., & Heymans, S. (2016). The Network Library: a framework to rapidly integrate network biology resources. Bioinformatics, 32(17), 473-478. https://doi.org/10.1093/bioinformatics/btw436
    • Smilde, B. J., Woudstra, L., Hing, G. F., Wouters, D., Zeerleder, S., Murk, J.-L., van Ham, M., Heymans, S., Juffermans, L. J. M., van Rossum, A. C., Niessen, H. W. M., Krijnen, P. A. J., & Emmens, R. W. (2016). Colchicine aggravates coxsackievirus B3 infection in mice. International Journal of Cardiology, 216, 58-65. https://doi.org/10.1016/j.ijcard.2016.04.144
    • Deckx, S., Heymans, S., & Papageorgiou, A.-P. (2016). The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?Faseb Journal, 30(8), 2651-2661. https://doi.org/10.1096/fj.201500096R
    • Pinto, Y. M., Elliott, P. M., Arbustini, E., Adler, Y., Anastasakis, A., Boehm, M., Duboc, D., Gimeno, J., de Groote, P., Imazio, M., Heymans, S., Klingel, K., Komajda, M., Limongelli, G., Linhart, A., Mogensen, J., Moon, J., Pieper, P. G., Seferovic, P. M., ... Charron, P. (2016). Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. European Heart Journal, 37(23), 1850-1858. https://doi.org/10.1093/eurheartj/ehv727
    • Gupta, S. K., Itagaki, R., Zheng, X., Batkai, S., Thum, S., Ahmad, F., Van Aelst, L. N., Sharma, A., Piccoli, M.-T., Weinberger, F., Fiedler, J., Heuser, M., Heymans, S., Falk, C. S., Foerster, R., Schrepfer, S., & Thum, T. (2016). miR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovascular Research, 110(2), 215-226. https://doi.org/10.1093/cvr/cvw030
    • Gast, M., Schroen, B., Voigt, A., Haas, J., Kuehl, U., Lassner, D., Skurk, C., Escher, F., Wang, X., Kratzer, A., Michalik, K., Papageorgiou, A., Peters, T., Loebel, M., Wilk, S., Althof, N., Prasanth, K. V., Katus, H., Meder, B., ... Poller, W. (2016). Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity. Journal of Molecular Cell Biology, 8(2), 178-181. https://doi.org/10.1093/jmcb/mjw003
    • Dennert, R., Streukens, B., Gommers, S., Heymans, S., & Bekkers, B. (2016). Perimyocarditis Complicated by Early Development of Constrictive Pericarditis. Canadian Journal of Cardiology, 32(3), 395.e11-395.e12. https://doi.org/10.1016/j.cjca.2015.06.004
    • Peters, T., Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., de Windt, L. J., van Oort, R. J., Heymans, S., & Schroen, B. (2016). Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice. PLOS ONE, 11(2), Article e0150236. https://doi.org/10.1371/journal.pone.0150236
    • Van Aelst, L. N. L., Summer, G., Li, S., Gupta, S. K., Heggermont, W., De Vusser, K., Carai, P., Naesens, M., Van Cleemput, J., Van de Werf, F., Vanhaecke, J., Thum, T., Waer, M., Papageorgiou, A. .-P., Schroen, B., & Heymans, S. (2016). RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection. American Journal of Transplantation, 16(1), 99-110. https://doi.org/10.1111/ajt.13421
    • Begieneman, M. P. V., Emmens, R. W., Rijvers, L., Kubat, B., Paulus, W. J., Vonk, A. B. A., Rozendaal, L., Biesbroek, P. S., Wouters, D., Zeerleder, S., van Ham, M., Heymans, S., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2016). Ventricular myocarditis coincides with atrial myocarditis in patients. Cardiovascular Pathology, 25(2), 141-148. https://doi.org/10.1016/j.carpath.2015.12.001
  • 2015
    • Summer, G., Kelder, T., Ono, K., Radonjic, M., Heymans, S., & Demchak, B. (2015). cyNeo4j: connecting Neo4j and Cytoscape. Bioinformatics, 31(23), 3868-3869. https://doi.org/10.1093/bioinformatics/btv460
    • Ounzain, S., Micheletti, R., Arnan, C., Plaisance, I., Cecchi, D., Schroen, B., Reverter, F., Alexanian, M., Gonzales, C., Ng, S. Y., Bussotti, G., Pezzuto, I., Notredame, C., Heymans, S., Guigo, R., Johnson, R., & Pedrazzini, T. (2015). CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. Journal of Molecular and Cellular Cardiology, 89, 98-112. https://doi.org/10.1016/j.yjmcc.2015.09.016
    • Hazebroek, M. R., Kemna, M. J., Schalla, S., Sanders-van Wijk, S., Gerretsen, S. C., Dennert, R., Merken, J., Kuznetsova, T., Staessen, J. A., Brunner-La Rocca, H. P., van Paassen, P., Tervaert, J. W. C., & Heymans, S. (2015). Prevalence and prognostic relevance of cardiac involvement in ANCA-associated vasculitis: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis. International Journal of Cardiology, 199, 170-179. https://doi.org/10.1016/j.ijcard.2015.06.087
    • Corsten, M., Heggermont, W., Papageorgiou, A.-P., Deckx, S., Tijsma, A., Verhesen, W., van Leeuwen, R., Carai, P., Thibaut, H.-J., Custers, K., Summer, G., Hazebroek, M., Verheyen, F., Neyts, J., Schroen, B., & Heymans, S. (2015). The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis. European Heart Journal, 36(42), 2909-U56. https://doi.org/10.1093/eurheartj/ehv321
    • Piers, S. R. D., Everaerts, K., van der Geest, R. J., Hazebroek, M. R., Siebelink, H.-M., Pison, L. A. F. G., Schalij, M. J., Bekkers, S. C. A. M., Heymans, S., & Zeppenfeld, K. (2015). Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy. Heart Rhythm, 12(10), 2106-2114. https://doi.org/10.1016/j.hrthm.2015.05.026
    • Deckx, S., Carai, P., Bateman, J., Heymans, S., & Papageorgiou, A.-P. (2015). Breeding Strategy Determines Rupture Incidence in Post-Infarct Healing WARPing Cardiovascular Research. PLOS ONE, 10(9), Article e0139199. https://doi.org/10.1371/journal.pone.0139199
    • Heymans, S., Gonzalez, A., Pizard, A., Papageorgiou, A. P., Lopez-Andres, N., Jaisser, F., Thum, T., Zannad, F., & Diez, J. (2015). Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential. European journal of heart failure, 17(8), 764-771. https://doi.org/10.1002/ejhf.312
    • Papageorgiou, A.-P., Heggermont, W., Rienks, M., Carai, P., Langouche, L., Verhesen, W., De Boer, R. A., & Heymans, S. (2015). Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Cardiovascular Research, 107(1), 78-88. https://doi.org/10.1093/cvr/cvv157
    • Devaux, Y., Zangrando, J., Schroen, B., Creemers, E. E., Pedrazzini, T., Chang, C.-P., Dorn, G. W. . II., Thum, T., & Heymans, S. (2015). Long noncoding RNAs in cardiac development and ageing. Nature Reviews Cardiology, 12(7), 415-425. https://doi.org/10.1038/nrcardio.2015.55
    • Diaz-Munoz, M. D., Bell, S. E., Fairfax, K., Monzon-Casanova, E., Cunningham, A. F., Gonzalez-Porta, M., Andrews, S. R., Bunik, V. I., Zarnack, K., Curk, T., Heggermont, W. A., Heymans, S., Gibson, G. E., Kontoyiannis, D. L., Ule, J., & Turner, M. (2015). The RNA-binding protein HuR is essential for the B cell antibody response. Nature Immunology, 16(4), 415-425. https://doi.org/10.1038/ni.3115
    • Ounzain, S., Micheletti, R., Beckmann, T., Schroen, B., Alexanian, M., Pezzuto, I., Crippa, S., Nemir, M., Sarre, A., Johnson, R., Dauvillier, J., Burdet, F., Ibberson, M., Guigo, R., Xenarios, I., Heymans, S., & Pedrazzini, T. (2015). Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs. European Heart Journal, 36(6), 353–368. https://doi.org/10.1093/eurheartj/ehu180
    • Bryant, C. E., Gay, N. J., Heymans, S., Sacre, S., Schaefer, L., & Midwood, K. S. (2015). Advances in Toll-like receptor biology: Modes of activation by diverse stimuli. Critical Reviews in Biochemistry and Molecular Biology, 50(5), 359-379. https://doi.org/10.3109/10409238.2015.1033511
  • 2014
    • Emmens, R. W., Woudstra, L., Papageorgiou, A., Carai, P., Smit, S., Seven-Deniz, S., Rozendaal, L., Paulus, W. J., Wouters, D., Zeerleder, S., Murk, J.-L., van Ham, M. S., Heymans, S., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2014). Lymphocytes Infiltrate the Quadriceps Muscle in Lymphocytic Myocarditis Patients: A Potential New Diagnostic Tool. Canadian Journal of Cardiology, 30(12), 1547-1554. https://doi.org/10.1016/j.cjca.2014.07.018
    • Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., Mahrholdt, H., McKenna, W. J., Mogensen, J., Nihoyannopoulos, P., Nistri, S., Pieper, P. G., Pieske, B., Rapezzi, C., Rutten, F. H., Tillmanns, C., ... Watkins, H. (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). European Heart Journal, 35(39), 2733-2779. https://doi.org/10.1093/eurheartj/ehu284
    • Jacobs, L., Thijs, L., Jin, Y., Zannad, F., Mebazaa, A., Rouet, P., Pinet, F., Bauters, C., Pieske, B., Tomaschitz, A., Mamas, M., Diez, J., McDonald, K., Cleland, J. G. F., Brunner-La Rocca, H.-P., Heymans, S., Latini, R., Masson, S., Sever, P., ... Staessen, J. A. (2014). Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Research, 28(5), 349-59. https://doi.org/10.7555/JBR.28.20140045
    • Westermann, D., & Heymans, S. (2014). Fibrosis or hypertrophy: let TIMPs decide. Cardiovascular Research, 103(2), 196-197. https://doi.org/10.1093/cvr/cvu160
    • Murdoch, C. E., Chaubey, S., Zeng, L., Yu, B., Ivetic, A., Walker, S. J., Vanhoutte, D., Heymans, S., Grieve, D. J., Cave, A. C., Brewer, A. C., Zhang, M., & Shah, A. M. (2014). Endothelial NADPH Oxidase-2 Promotes Interstitial Cardiac Fibrosis and Diastolic Dysfunction Through Proinflammatory Effects and Endothelial-Mesenchymal Transition. Journal of the American College of Cardiology, 63(24), 2734-2741. https://doi.org/10.1016/j.jacc.2014.02.572
    • Leite-Moreira, A. F., Lourenco, A. P., Balligand, J.-L., Bauersachs, J., Clerk, A., De Windt, L. J., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Kaminski, K. A., Knoell, R., Mayr, M., Tarone, G., Thum, T., & Tocchetti, C. G. (2014). ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models. European journal of heart failure, 16(5), 509-518. https://doi.org/10.1002/ejhf.66
    • Tarone, G., Balligand, J.-L., Bauersachs, J., Clerk, A., De Windt, L., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Knoell, R., Leite-Moreira, A. F., Lourenco, A. P., Mayr, M., Thum, T., & Tocchetti, C. G. (2014). Targeting myocardial remodelling to develop novel therapies for heart failure A position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure, 16(5), 494-508. https://doi.org/10.1002/ejhf.62
    • Beaumont, J., Lopez, B., Hermida, N., Schroen, B., Jose, G. S., Heymans, S., Valencia, F., Jose Gomez-Doblas, J., De Teresa, E., Diez, J., & Gonzalez, A. (2014). microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation. Clinical Science, 126(7-8), 497-506. https://doi.org/10.1042/CS20130538
    • Papageorgiou, A.-P., & Heymans, S. (2014). Peroxidasin-like protein: expanding the horizons of matrix biology. Cardiovascular Research, 101(3), 342-343. https://doi.org/10.1093/cvr/cvu017
    • Rienks, M., Papageorgiou, A.-P., Frangogiannis, N. G., & Heymans, S. (2014). Myocardial Extracellular Matrix An Ever-Changing and Diverse Entity. Circulation Research, 114(5), 872-888. https://doi.org/10.1161/CIRCRESAHA.114.302533
    • Hazebroek, M. R., Everaerts, K., & Heymans, S. (2014). Diagnostic approach of myocarditis: strike the golden mean. Netherlands Heart Journal, 22(2), 80-84. https://doi.org/10.1007/s12471-013-0499-3
    • Hazebroek, M. R., van Paassen, P., Weerwind, P. W., Cooper, L. T. . J., Uriel, N., Caliskan, K., de Vries, B., Maessen, J. G., Autschbach, R., Heymans, S., & Donker, D. W. (2014). A passionate endurance cyclist ultimately survives sudden death in right ventricular giant cell myocarditis. International Journal of Cardiology, 170(3), E74-E75. https://doi.org/10.1016/j.ijcard.2013.11.028
Overview