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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Casper Schalkwijk

Professor

Prof. Casper Schalkwijk studied chemistry at University Utrecht and graduated in biochemistry. At the same university he obtained his PhD in 1992. He did post-graduate training in endothelial cell biology at TNO-PG in Leiden. He was appointed in 1995 as assistant professor and staff member at the Department of Clinical Chemistry at the Vrije Universiteit Medical Cente in Amsterdam and from 2004 as associate professor. He has led the Vascular Unit. He moved to the Department of Internal Medicine at Maastricht University in 2005, where he is heading the Laboratory for Metabolism and Vascular Medicine (~15fte). He was appointed as Professor of Experimental Internal Medicine at the Faculty of Health, Medicine and Life Sciences (FHML) of Maastricht UMC+ in 2011.

His main research themes are obesity, insulin resistance, endothelial function and vascular complications. The importance of endothelial dysfunction for the development of diabetic complications is studied in epidemiological setting with the availability of several cohorts and with experimental ex-vivo -, animal - and cell work. He has led several clinical studies. A major aim of his programme is to deliver specific and sensitive diagnostic biomarkers for the identification of patients developing  type 2 diabetes and to identify patients with high risk of vascular complications. Robust analytical techniques for measurements of biomarkers with multi-array technology and with UPLC-MSMS are available. A second aim of his programme is to obtain insight in the pathophysiology of vascular complications in diabetes. His current studies focus mainly on the importance non-enzymatic glycation for the development of diabetes and diabetic complications. He discovered, as one of the first, the link between AGEs and vascular complications in individuals with and without diabetes. He is an (inter)nationally recognised expert in the field of glycation. His lab is one of the most renowned labs in this field.The work has been supported by several grants and is now granted by the Diabetes Fonds Nederland, EFSD, NWO, ZonMw and NVWA.

Casper-schalkwijk

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 5.324
T: +31(0)43 388 21 86

  • 2016
    • van Dooren, F., Verhey, F. R. J., Pouwer, F., Schalkwijk, C. G., Sep, S. J. S., Stehouwer, C. D. A., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J. H., Koster, A., Schram, M. T., & Denollet, J. (2016). Association of Type D personality with increased vulnerability to depression: is there a role for inflammation or endothelial dysfunction? - the Maastricht Study. Journal of Affective Disorders, 189, 118-125. https://doi.org/10.1016/j.jad.2015.09.028
    • van Greevenbroek, M. M. J., Schalkwijk, C. G., & Stehouwer, C. D. A. (2016). Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances. F1000Research, 5, Article 2515. https://doi.org/10.12688/f1000research.8971.1
    • van der Heijden, R. A., Morrison, M. C., Sheedfar, F., Mulder, P., Schreurs, M., Hommelberg, P. P. H., Hofker, M. H., Schalkwijk, C., Kleemann, R., Tietge, U. J. F., Koonen, D. P. Y., & Heeringa, P. (2016). Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity. Mediators of Inflammation, 2016, Article 2042107. https://doi.org/10.1155/2016/2042107
  • 2015
    • Teunissen-Beekman, K. F. M., Dopheide, J., Geleijnse, J. M., Bakker, S. J., Brink, E. J., de Leeuw, P. W., Schalkwijk, C. G., & van Baak, M. A. (2015). Dietary proteins improve endothelial function under fasting conditions but not in the postprandial state, with no effects on markers of low-grade inflammation. British Journal of Nutrition, 114(11), 1819-1828. https://doi.org/10.1017/s0007114515003530
    • Gaens, K. H. J., Ferreira, I., van de Waarenburg, M. P. H., van Greevenbroek, M. M., van der Kallen, C. J. H., Dekker, J. M., Nijpels, G., Rensen, S. S., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Protein-Bound Plasma N-epsilon-(Carboxymethyl) lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity-Related Increase in Inflammation The Hoorn and CODAM Studies. Arteriosclerosis Thrombosis and Vascular Biology, 35(12), 2707-2713. https://doi.org/10.1161/ATVBAHA.115.306106
    • Gijsbers, L., Dower, J. I., Schalkwijk, C. G., Kusters, Y. H. A. M., Bakker, S. J. L., Hollman, P. C. H., & Geleijnse, J. M. (2015). Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study. British Journal of Nutrition, 114(9), 1419-1426. https://doi.org/10.1017/S0007114515002986
    • van der Heijden, R. A., Bijzet, J., Meijers, W. C., Yakala, G. K., Kleemann, R., Nguyen, T. Q., de Boer, R. A., Schalkwijk, C. G., Hazenberg, B. P. C., Tietge, U. J. F., & Heeringa, P. (2015). Obesity-induced chronic inflammation in high fat diet challenged C57BL/6J mice is associated with acceleration of age-dependent renal amyloidosis. Scientific Reports, 5, Article 16474. https://doi.org/10.1038/srep16474
    • Begieneman, M. P. V., Rijvers, L., Kubat, B., Paulus, W. J., Vonk, A. B. A., van Rossum, A. C., Schalkwijk, C. G., Stooker, W., Niessen, H. W. M., & Krijnen, P. A. J. (2015). Atrial Fibrillation Coincides with the Advanced Glycation End Product N-epsilon-Carboxymethyl)Lysine in the Atrium. American Journal of Pathology, 185(8), 2096-2104. https://doi.org/10.1016/j.ajpath.2015.04.018
    • Cornelis, T., Eloot, S., Vanholder, R., Glorieux, G., van der Sande, F. M., Scheijen, J. L., Leunissen, K. M., Kooman, J. P., & Schalkwijk, C. G. (2015). Protein-bound uraemic toxins, dicarbonyl stress and advanced glycation end products in conventional and extended haemodialysis and haemodiafiltration. Nephrology Dialysis Transplantation, 30(8), 1395-1402. https://doi.org/10.1093/ndt/gfv038
    • Schalkwijk, C. G. (2015). Vascular AGE-ing by methylglyoxal: the past, the present and the future. Diabetologia, 58(8), 1715-1719. https://doi.org/10.1007/s00125-015-3597-5
    • Soedamah-Muthu, S. S., Livingstone, S. J., Charlton-Menys, V., Betteridge, D. J., Hitman, G. A., Neil, H. A. W., Bao, W., DeMicco, D. A., Preston, G. M., Fuller, J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Durrington, P. N., & Colhoun, H. M. (2015). Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. Diabetologia, 58(7), 1494-1502. https://doi.org/10.1007/s00125-015-3586-8
    • Dower, J. I., Geleijnse, J. M., Gijsbers, L., Schalkwijk, C., Kromhout, D., & Hollman, P. C. (2015). Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial. Journal of Nutrition, 145(7), 1459-1463. https://doi.org/10.3945/jn.115.211888
    • Maessen, D. E. M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases. Clinical Science, 128(12), 839-861. https://doi.org/10.1042/CS20140683
    • Maessen, D. E., Hanssen, N. M., Scheijen, J. L., van der Kallen, C. J., van Greevenbroek, M. M., Stehouwer, C. D., & Schalkwijk, C. G. (2015). Post-Glucose Load Plasma alpha-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. Diabetes Care, 38(5), 913-920. https://doi.org/10.2337/dc14-2605
    • Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Jansen, E. H. J. M., Feskens, E. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., Bravenboer, B., & Stehouwer, C. D. A. (2015). Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study. Acta Diabetologica, 52(2), 337-348. https://doi.org/10.1007/s00592-014-0646-3
    • Mommersteeg, P. M. C., Schoemaker, R. G., Eisel, U. L. M., Garrelds, I. M., Schalkwijk, C. G., & Kop, W. J. (2015). Nitric Oxide Dysregulation in Patients With Heart Failure: The Association of Depressive Symptoms With L-Arginine, Asymmetric Dimethylarginine, Symmetric Dimethylarginine, and Isoprostane. Psychosomatic Medicine, 77(3), 292-302. https://doi.org/10.1097/PSY.0000000000000162
    • Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., & Stehouwer, C. D. (2015). Plasma levels of matrix metalloproteinase-2,-3,-10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study. Cardiovascular Diabetology, 14(1), Article 31. https://doi.org/10.1186/s12933-015-0195-2
    • van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015). A Healthy Diet is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease. Journal of Nutrition, 145(3), 532-540. https://doi.org/10.3945/jn.114.201236
    • Spauwen, P. J. J., van Eupen, M. G. A., Köhler, S., Stehouwer, C. D. A., Verhey, F. R. J., van der Kallen, C. J. H., Sep, S. J. S., Koster, A., Schaper, N. C., Dagnelie, P. C., Schalkwijk, C. G., Schram, M. T., & van Boxtel, M. P. J. (2015). Associations of Advanced Glycation End-Products With Cognitive Functions in Individuals With and Without Type 2 Diabetes: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 100(3), 951-960. https://doi.org/10.1210/jc.2014-2754
    • van Bussel, F. C. G., van Bussel, B. C. T., Hoeks, A. P. G., op 't Roodt, J., Henry, R. M. A., Ferreira, I., Vanmolkot, F. H. M., Schalkwijk, C. G., Stehouwer, C. D. A., & Reesink, K. D. (2015). A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery. PLOS ONE, 10(2), Article e0115977. https://doi.org/10.1371/journal.pone.0115977
    • Fronczek, J., Lulf, R., Korkmaz, H. I., Witte, B. I., de Goot, F. R. W. V., Begieneman, M. P. V., Schalkwijk, C. G., Krijnen, P. A. J., Rozendaal, L., Niessen, H. W. M., & Reijnders, U. J. L. (2015). Analysis of inflammatory cells and mediators in skin wound biopsies to determine wound age in living subjects in forensic medicine. Forensic Science International, 247, 7-13. https://doi.org/10.1016/j.forsciint.2014.11.014
    • van Moorsel, D., van Greevenbroek, M. M. J., Schaper, N. C., Henry, R. M. A., Geelen, C. C., van Rossum, E. F. C., Nijpels, G., 't Hart, L. M., Schalkwijk, C. G., van der Kallen, C. J. H., Sauerwein, H. P., Dekker, J. M., Stehouwer, C. D. A., & Havekes, B. (2015). BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies. European Journal of Endocrinology, 173(4), 455-464. https://doi.org/10.1530/EJE-15-0381
    • Engelen, L., Schalkwijk, C. G., Eussen, S. J. P. M., Scheijen, J. L. J. M., Soedamah-Muthu, S. S., Chaturvedi, N., Fuller, J. H., & Stehouwer, C. D. A. (2015). Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovascular Diabetology, 14(1), Article 67. https://doi.org/10.1186/s12933-015-0231-2
    • Hanssen, N. M. J., Beulens, J. W. J., van Dieren, S., Scheijen, J. L. J. M., van der A, D. L., Spijkerman, A. M. W., van der Schouw, Y. T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL). Diabetes, 64(1), 257-265. https://doi.org/10.2337/db13-1864
    • Prior, D. L., Somaratne, J. B., Jenkins, A. J., Yii, M., Newcomb, A. E., Schalkwijk, C. G., Black, M. J., Kelly, D. J., & Campbell, D. J. (2015). Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery. Open Heart, 2(1), Article e000278. https://doi.org/10.1136/openhrt-2015-000278
    • de Courten, B., de Courten, M. P. J., Schalkwijk, C. G., Walker, K. Z., & Forbes, J. (2015). Dietary Advanced Glycation End Products Consumption as a Direct Modulator of Insulin Sensitivity in Overweight Humans: A Study Protocol for a Double-Blind, Randomized, Two Period Cross-Over Trial. JMIR Research Protocols, 4(3), Article e93. https://doi.org/10.2196/resprot.4552
  • 2014
    • Herbert, A., Cruickshank, J. K., Laurent, S., The Reference Values for Arterial Measurements Collaboration, Stehouwer, C., Ferreira, I., Schalkwijk, C., van Greevenbroek, M., van der Kallen, C., van de Laar, R., Staessen, J., & Boutouyrie, P. (2014). Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal, 35(44), 3122–3133. https://doi.org/10.1093/eurheartj/ehu293
    • Engelen, L., Soedamah-Muthu, S. S., Geleijnse, J. M., Toeller, M., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., & Stehouwer, C. D. A. (2014). Higher dietary salt intake is associated with microalbuminuria, but not with retinopathy in individuals with type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetologia, 57(11), 2315-2323. https://doi.org/10.1007/s00125-014-3367-9
    • Wijnands, J. M. A., Boonen, A., Dagnelie, P. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Schalkwijk, C. G., Feskens, E. J. M., Stehouwer, C. D. A., van der Linden, S., & Arts, I. C. W. (2014). The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. Rheumatology, 53(11), 2053-2062. https://doi.org/10.1093/rheumatology/keu239
    • Eriksen, C., Svensson, R. B., Scheijen, J., Hag, A. M. F., Schalkwijk, C., Praet, S. F. E., Schjerling, P., Kjaer, M., Magnusson, S. P., & Couppe, C. (2014). Systemic stiffening of mouse tail tendon is related to dietary advanced glycation end products but not high-fat diet or cholesterol. Journal of Applied Physiology, 117(8), 840-847. https://doi.org/10.1152/japplphysiol.00584.2014
    • Hanssen, N. M. J., Brouwers, O., Gijbels, M. J., Wouters, K., Wijnands, E., Cleutjens, J. P. M., De Mey, J. G., Miyata, T., Biessen, E. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE(-/-) mice with or without diabetes. Cardiovascular Research, 104(1), 160-170. https://doi.org/10.1093/cvr/cvu189
    • Scholtes, V. P. W., Peeters, W., van Lammeren, G. W., Howard, D. P. J., de Vries, J.-P. P. M., de Borst, G. J., Redgrave, J. N., Kemperman, H., Schalkwijk, C. G., den Ruijter, H. M., de Kleijn, D. P. V., Moll, F. L., Rothwell, P. M., & Pasterkamp, G. (2014). Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques. Atherosclerosis, 235(2), 418-423. https://doi.org/10.1016/j.atherosclerosis.2014.05.941
    • Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Feskens, E. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., Bravenboer, B., & Stehouwer, C. D. A. (2014). Complement Factor 3 Is Associated With Insulin Resistance and With Incident Type 2 Diabetes Over a 7-Year Follow-up Period: The CODAM Study. Diabetes Care, 37(7), 1900-1909. https://doi.org/10.2337/dc13-2804
    • Hertle, E., van Greevenbroek, M. M., Arts, I. C., van der Kallen, C. J., Geijselaers, S. L., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. (2014). Distinct associations of complement C3a and its precursor C3 with atherosclerosis and cardiovascular disease The CODAM study. Thrombosis and Haemostasis, 111(6), 1102-1111. https://doi.org/10.1160/TH13-10-0831
    • van Sloten, T. T., Schram, M. T., Adriaanse, M. C., Dekker, J. M., Nijpels, G., Teerlink, T., Scheffer, P. G., Pouwer, F., Schalkwijk, C. G., Stehouwer, C. D. A., & Henry, R. M. A. (2014). Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study. Psychological Medicine, 44(7), 1403-1416. https://doi.org/10.1017/S0033291713002043
    • Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., de Kleijn, D. P., Stehouwer, C. D. A., Pasterkamp, G., & Schalkwijk, C. G. (2014). Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. European Heart Journal, 35(17), 1137-1146. https://doi.org/10.1093/eurheartj/eht402
    • Danielsen, I., Om, C. G., Rytter, D., Halldorsson, T. I., Bech, B. H., Henriksen, T. B., Stehouwer, C. D. A., Schalkwijk, C. G., Vaag, A. A., & Olsen, S. F. (2014). Subclinical Inflammation During Third Trimester of Pregnancy Was Not Associated with Markers of the Metabolic Syndrome in Young Adult Offspring. Obesity, 22(5), 1351-1358. https://doi.org/10.1002/oby.20650
    • Hanssen, N. M. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Methylglyoxal and glyoxalase I in atherosclerosis. Biochemical Society Transactions, 42(2), 443-449. https://doi.org/10.1042/BST20140001
    • Beijers, H. J. B. H., Ferreira, I., Bravenboer, B., Henry, R. M. A., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2014). Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study. Atherosclerosis, 233(1), 310-318. https://doi.org/10.1016/j.atherosclerosis.2013.12.002
    • Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M., & Rutten, E. P. A. (2014). Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD. Respiratory Research, 15(1), Article 24. https://doi.org/10.1186/1465-9921-15-24
    • Heringa, S. M., van den Berg, E., Reijmer, Y. D., Nijpels, G., Stehouwer, C. D. A., Schalkwijk, C. G., Teerlink, T., Scheffer, P. G., van den Hurk, K., Kappelle, L. J., Dekker, J. M., & Biessels, G. J. (2014). Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population - the Hoorn Study. Psychoneuroendocrinology, 40(1), 108-118. https://doi.org/10.1016/j.psyneuen.2013.11.011
    • Heijnen, B. F. J., Van Essen, H., Schalkwijk, C. G., Janssen, B. J. A., & Struijker-Boudier, H. A. J. (2014). Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats. Hypertension Research, 37(2), 100-109. https://doi.org/10.1038/hr.2013.99
    • van Bilsen, M., Daniels, A., Brouwers, O., Janssen, B. J. A., Derks, W. J. A., Brouns, A. E., Munts, C., Schalkwijk, C. G., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2014). Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice. PLOS ONE, 9(1), Article e85078. https://doi.org/10.1371/journal.pone.0085078
    • Bouman, A. C., Cheung, Y. W., Spronk, H. M., Schalkwijk, C. G., ten Cate, H., ten Wolde, M., & ten Cate-Hoek, A. J. (2014). Biomarkers for post thrombotic syndrome: A case-control study. Thrombosis Research, 134(2), 369-375. https://doi.org/10.1016/j.thromres.2014.06.010
    • Hertle, E., van Greevenbroek, M. M. J., Arts, I. C. W., van der Kallen, C. J. H., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2014). Complement activation products C5a and sC5b-9 are associated with low-grade inflammation and endothelial dysfunction, but not with atherosclerosis in a cross-sectional analysis: The CODAM study. International Journal of Cardiology, 174(2), 400-403. https://doi.org/10.1016/j.ijcard.2014.04.057
    • van Greevenbroek, M. M. J., Arts, I. C. W., van der Kallen, C. J. H., Dagnelie, P. C., Ferreira, I., Jansen, E., Schalkwijk, C. G., Feskens, E. J. M., & Stehouwer, C. D. A. (2014). Complement C3 Is Inversely Associated with Habitual Intake of Provitamin A but Not with Dietary Fat, Fatty Acids, or Vitamin E in Middle-Aged to Older White Adults and Positively Associated with Intake of Retinol in Middle-Aged to Older White Women. Journal of Nutrition, 144(1), 61-67. https://doi.org/10.3945/jn.113.181628
    • Gaens, K. H., Goossens, G. H., Niessen, P. M., van Greevenbroek, M. M., van der Kallen, C. J., Niessen, H. W., Rensen, S. S., Buurman, W. A., Greve, J. W., Blaak, E. E., van Zandvoort, M. A., Bierhaus, A., Stehouwer, C. D., & Schalkwijk, C. G. (2014). Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance. Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1199-1208. https://doi.org/10.1161/ATVBAHA.113.302281
    • Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Engelen, L., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M., & Rutten, E. P. A. (2014). Plasma advanced glycation end-products and skin autofluorescence are increased in COPD. European Respiratory Journal, 43(2), 430-438. https://doi.org/10.1183/09031936.00135312
    • Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., ... Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023
    • Brouwers, O., Niessen, P. M. G., Miyata, T., Ostergaard, J. A., Flyvbjerg, A., Peutz-Kootstra, C. J., Sieber, J., Mundel, P. H., Brownlee, M., Janssen, B. J. A., De Mey, J. G. R., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes. Diabetologia, 57(1), 224-235. https://doi.org/10.1007/s00125-013-3088-5
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