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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Stephane Heymans

Professor

Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.

Website www.hfresearch.eu

Stephane-heymans

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2024
    • Sikking, M. A., Harding, D., Henkens, M. T. H. M., Stroeks, S. L. V. M., Venner, M. F. G. H. M., Nihant, B., van Leeuwen, R. E. W., Fanti, S., Li, X., van Paassen, P., Knackstedt, C., Brunner-la Rocca, H.-P., van Empel, V. P. M., Verdonschot, J. A. J., Marelli-Berg, F. M., & Heymans, S. R. B. (2024). Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. Circulation Research. Advance online publication. https://doi.org/10.1161/CIRCRESAHA.124.325183
    • Stroeks, S. L. V. M., Henkens, M. T. H. M., Dominguez, F., Merlo, M., Hellebrekers, D. M. E. I., Gonzalez-Lopez, E., Dal Ferro, M., Ochoa, J. P., Venturelli, F., Claes, G. R. F., Venner, M. F. G. H. M., Krapels, I. P. C., Vanhoutte, E. K., van Paassen, P., van den Wijngaard, A., Sikking, M. A., van Leeuwen, R., Abdul Hamid, M., Li, X., ... Verdonschot, J. A. J. (2024). Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease. JACC: Heart Failure. Advance online publication. https://doi.org/10.1016/j.jchf.2024.08.011
    • Verdonschot, J. A. J., Fuster, J. J., Walsh, K., & Heymans, S. R. B. (2024). The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. European Heart Journal, Article ehae682. https://doi.org/10.1093/eurheartj/ehae682
    • Verdonschot, J. A. J., Heymans, S. R. B., & Van Linthout, S. (2024). The next era of gene-specific clinical care in patients with dilated cardiomyopathy. European journal of heart failure, 26(10), 2169-2172. https://doi.org/10.1002/ejhf.3446
    • Yu, Y.-L., Siwy, J., An, D.-W., González, A., Hansen, T., Latosinska, A., Pellicori, P., Ravassa, S., Mariottoni, B., Verdonschot, J. A., Ahmed, F., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J. J., Girerd, N., Clark, A. L., Verhamme, P., Nawrot, T. S., ... HOMAGE investigators (2024). Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial. Heart, 110(19), 1180-1187. Article heartjnl-2023-323796. https://doi.org/10.1136/heartjnl-2023-323796
    • Wei, F.-F., Pellicori, P., Ferreira, J. P., González, A., Mariottoni, B., An, D.-W., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Clark, A. L., Li, Y., Nawrot, T. S., Díez, J., Zannad, F., ... HOMAGE investigators (2024). Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial. Hypertension Research. Advance online publication. https://doi.org/10.1038/s41440-024-01843-z
    • Wei, F.-F., Mariottoni, B., An, D.-W., Pellicori, P., Yu, Y.-L., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Li, Y., Clark, A. L., Nawrot, T. S., Ferreira, J. P., Zannad, F., Cleland, J. G. F., ... HOMAGE investigators (2024). Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure. Esc heart failure. Advance online publication. https://doi.org/10.1002/ehf2.15000
    • Beijnink, C. W. H., Raafs, A. G., Vos, J. L., Verdonschot, J. A. J., Sikking, M. A., Rodwell, L., Heymans, S. R. B., & Nijveldt, R. (2024). Papillary Muscle Delayed Hyperenhancement: Prevalence and Clinical Implications in a Large Population With Dilated Cardiomyopathy. JACC: Advances, 3(8), Article 101103. https://doi.org/10.1016/j.jacadv.2024.101103
    • Machiraju, P., Srinivas, R., Kannan, R., George, R., Heymans, S., Mukhopadhyay, R., & Ghosh, A. (2024). Paired Transcriptomic Analyses of Atheromatous and Control Vessels Reveal Novel Autophagy and Immunoregulatory Genes in Peripheral Artery Disease. Cells, 13(15), Article 1269. https://doi.org/10.3390/cells13151269
    • Heymans, S., Van Linthout, S., Kraus, S. M., Cooper, L. T., & Ntusi, N. A. B. (2024). Clinical Characteristics and Mechanisms of Acute Myocarditis. Circulation Research, 135(2), 397-411. https://doi.org/10.1161/CIRCRESAHA.124.324674
    • Nihant, B., Verdonschot, J., Heymans, S., Breuer, M., & Adriaens, M. (2024). Computational models of cardiac metabolism reveal distinct metabolic phenotypes in dilated cardiomyopathy patients. European journal of heart failure, 26, 640-641.
    • Falcao-Pires, I., Ferreira, A. F., Trindade, F., Bertrand, L., Ciccarelli, M., Visco, V., Dawson, D., Hamdani, N., Van Laake, L. W., Lezoualc'h, F., Linke, W. A., Lunde, I. G., Rainer, P. P., Abdellatif, M., van der Velden, J., Cosentino, N., Paldino, A., Pompilio, G., Zacchigna, S., ... Tocchetti, C. G. (2024). Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function. European journal of heart failure, 26(7), 1454-1479. https://doi.org/10.1002/ejhf.3264
    • Wiethoff, I., Sikking, M., Evers, S., Gabrio, A., Henkens, M., Michels, M., Verdonschot, J., Heymans, S., & Hiligsmann, M. (2024). Quality of life and societal costs in patients with dilated cardiomyopathy. European heart journal - Quality of care & clinical outcomes, 10(4), 334-344. Article qcad056. https://doi.org/10.1093/ehjqcco/qcad056
    • Sikking, M. A., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Cossins, B., van Deuren, R. C., Steehouwer, M., Riksen, N. P., van den Wijngaard, A., Brunner, H. G., Hoischen, A., Verdonschot, J. A. J., & Heymans, S. R. B. (2024). Clonal Hematopoiesis has Prognostic Value in Dilated Cardiomyopathy independent of Age and Clone Size. JACC: Heart Failure, 12(5), 905-914. https://doi.org/10.1016/j.jchf.2023.06.037
    • Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A. J., Rossignol, P., Cleland, J. G. F., Zannad, F., Girerd, N., & HOMAGE Trial Committees and Investigators (2024). Proteomic profiles of left atrial volume and its influence on response to spironolactone: Findings from the HOMAGE trial and STANISLAS cohort. European journal of heart failure, 26(5), 1231-1241. https://doi.org/10.1002/ejhf.3202
    • Weerts, J., Raafs, A. G., Sandhoefner, B., van der Heide, F. C. T., Mourmans, S. G. J., Wolff, N., Finger, R. P., Falahat, P., Wintergerst, M. W. M., van Empel, V. P. M., & Heymans, S. R. B. (2024). Retinal Vascular Changes in Heart Failure with Preserved Ejection Fraction Using Optical Coherence Tomography Angiography. Journal of Clinical Medicine, 13(7), Article 1892. https://doi.org/10.3390/jcm13071892
    • Verdonschot, J. A. J., Hellebrekers, D. M. E. I., van Empel, V. P. M., Heijligers, M., de Munnik, S., Coonen, E., Dreesen, J. C. M. F., van den Wijngaard, A., Brunner, H. G., Zamani Esteki, M., Heymans, S. R. B., de Die-Smulders, C. E. M., & Paulussen, A. D. C. (2024). Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases. Circulation: Genomic and Precision Medicine, 17(2), Article E004416. https://doi.org/10.1161/CIRCGEN.123.004416
    • Verdonschot, J. A. J., & Heymans, S. R. B. (2024). Dilated cardiomyopathy: second hits knock-down the heart. European Heart Journal, 45(7), 500-501. https://doi.org/10.1093/eurheartj/ehad778
    • Santos-Ferreira, D., Diaz, S. O., Ferreira, J. P., Girerd, N., Pellicori, P., Mariottoni, B., Cosmi, F., Hazebroek, M., Verdonschot, J. A. J., Cuthbert, J., Petutschnigg, J., Heymans, S., Staessen, J. A., Pieske, B., Edelmann, F., Clark, A. L., Rossignol, P., Fontes-Carvalho, R., Cleland, J. G. F., & Zannad, F. (2024). Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial. Esc heart failure, 11(1), 209-218. https://doi.org/10.1002/ehf2.14465
    • Shanbagh, S., Gadde, S. G., Shetty, R., Heymans, S., Abilash, V. G., Chaurasia, S. S., & Ghosh, A. (2024). Hyperglycemia-induced miR182-5p drives glycolytic and angiogenic response in Proliferative Diabetic Retinopathy and RPE cells via depleting FoxO1. Experimental Eye Research, 238, Article 109713. https://doi.org/10.1016/j.exer.2023.109713
    • McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Boehm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J. G. F., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., Lainscak, M., ... ESC Scientific Document Group (2024). 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European journal of heart failure, 26(1), 5-17. https://doi.org/10.1002/ejhf.3024
    • Simmonds, S. J., Grootaert, M. O. J., Cuijpers, I., Carai, P., Geuens, N., Herwig, M., Baatsen, P., Hamdani, N., Luttun, A., Heymans, S., & Jones, E. A. V. (2024). Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction. European heart journal open, 4(1), Article oead129. https://doi.org/10.1093/ehjopen/oead129
  • 2023
    • Ciccarelli, M., Pires, I. F., Bauersachs, J., Bertrand, L., Beauloye, C., Dawson, D., Hamdani, N., Hilfiker-Kleiner, D., van Laake, L. W., Lezoualc'h, F., Linke, W. A., Lunde, I. G., Rainer, P. P., Rispoli, A., Visco, V., Carrizzo, A., Ferro, M. D., Stolfo, D., van der Velden, J., ... Tocchetti, C. G. (2023). Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function. Cardiovascular Research, 119(14), 2390-2404. Article cvad088. https://doi.org/10.1093/cvr/cvad088
    • Babu, V. S., Mallipatna, A., Dudeja, G., Shetty, R., Nair, A. P., Tun, S. B. B., Ho, C. E. H., Chaurasia, S. S., Bhattacharya, S. S., Verma, N. K., Lakshminarayanan, R., Guha, N., Heymans, S., Barathi, V. A., & Ghosh, A. (2023). Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors. Translational Research, 261(1), 41-56. https://doi.org/10.1016/j.trsl.2023.07.001
    • Sikking, M. A., Stroeks, S. L. V. M., Marelli-Berg, F., Heymans, S. R. B., Ludewig, B., & Verdonschot, J. A. J. (2023). Immunomodulation of Myocardial Fibrosis. JACC: Basic to Translational Science, 8(11), 1477-1488. https://doi.org/10.1016/j.jacbts.2023.03.015
    • Seferovic, P. M., Polovina, M., Rosano, G., Bozkurt, B., Metra, M., Heymans, S., Mullens, W., Bauersachs, J., Sliwa, K., de Boer, R. A., Farmakis, D., Thum, T., Olivotto, I., Rapezzi, C., Linhart, A., Corrado, D., Tschöpe, C., Milinkovic, I., Bayes Genis, A., ... Coats, A. J. (2023). State-of-the-art document on optimal contemporary management of cardiomyopathies. European journal of heart failure, 25(11), 1899-1922. Article ejhf2979. https://doi.org/10.1002/ejhf.2979
    • McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J. G. F., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., Lainscak, M., ... ESC Scientific Document Group (2023). 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal, 44(37), 3627-3639. https://doi.org/10.1093/eurheartj/ehad195
    • Heymans, S., Lakdawala, N. K., Tschöpe, C., & Klingel, K. (2023). Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches. Lancet, 402(10406), 998-1011. https://doi.org/10.1016/S0140-6736(23)01241-2
    • Raafs, A. G., Adriaans, B. P., Henkens, M. T. H. M., Verdonschot, J. A. J., Abdul Hamid, M. A., Díez, J., Knackstedt, C., van Empel, V. P. M., Brunner-La Rocca, H. P., González, A., Wildberger, J. E., Heymans, S. R. B., & Hazebroek, M. R. (2023). Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study. Journal of Clinical Medicine, 12(17), Article 5695. https://doi.org/10.3390/jcm12175695
    • Vos, J. L., Raafs, A. G., Henkens, M. T. H. M., Pedrizzetti, G., van Deursen, C. J., Rodwell, L., Heymans, S. R. B., & Nijveldt, R. (2023). CMR-derived left ventricular intraventricular pressure gradients identify different patterns associated with prognosis in dilated cardiomyopathy. European Heart Journal Cardiovascular Imaging, 24(9), 1231-1240. https://doi.org/10.1093/ehjci/jead083
    • Sikking, M. A., Stroeks, S. L. V. M., Waring, O. J., Henkens, M. T. H. M., Riksen, N. P., Hoischen, A., Heymans, S. R. B., & Verdonschot, J. A. J. (2023). Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist’s Point of View. Journal of the American Heart Association, 12(15), Article e030603. https://doi.org/10.1161/JAHA.123.030603
    • Kobayashi, M., Huttin, O., Ferreira, J. P., Duarte, K., Gonzalez, A., Heymans, S., Verdonschot, J. A. J., Brunner-La Rocca, H.-P., Pellicori, P. L., Clark, A., Petutschnigg, J., Edelmann, F. G., Cleland, J., Rossignol, P., Zannad, F., Girerd, N., & HOMAGE Trial Committees and Investigators (2023). A machine learning-derived echocardiographic algorithm identifies people at risk of heart failure with distinct cardiac structure, function, and response to spironolactone: findings from the HOMAGE trial. European journal of heart failure, 25(8), 1284-1289. https://doi.org/10.1002/ejhf.2859
    • Heymans, S., & Cooper, L. T. (2023). Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms. Nature Reviews Cardiology, 20(8), 575-575. https://doi.org/10.1038/s41569-023-00904-z
    • Sikking, M. A., Stroeks, S. L. V. M., Henkens, M. T. H. M., Venner, M. F. G. H. M., Li, X., Heymans, S. R. B., Hazebroek, M. R., & Verdonschot, J. A. J. (2023). Cardiac Inflammation in Adult-Onset Genetic Dilated Cardiomyopathy. Journal of Clinical Medicine, 12(12), Article 3937. https://doi.org/10.3390/jcm12123937
    • Girerd, N., Levy, D., Duarte, K., Ferreira, J. P., Ballantyne, C., Collier, T., Pizard, A., Björkman, J., Butler, J., Clark, A., Cleland, J. G., Delles, C., Diez, J., González, A., Hazebroek, M., Ho, J., Huby, A. C., Hwang, S. J., Latini, R., ... Zannad, F. (2023). Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circulation-Heart Failure, 16(5), 426-441. Article e009694. https://doi.org/10.1161/CIRCHEARTFAILURE.122.009694
    • Verdonschot, J. A. J., Wang, P., Derks, K. W. J., Adriaens, M. E., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Sikking, M., de Koning, B., van den Wijngaard, A., Krapels, I. P. C., Nabben, M., Brunner, H. G., & Heymans, S. R. B. (2023). Clustering of Cardiac Transcriptome Profiles Reveals Unique Subgroups of Dilated Cardiomyopathy Patients. JACC: Basic to Translational Science, 8(4), 406-418. https://doi.org/10.1016/j.jacbts.2022.10.010
    • Stroeks, S. L. V. M., Lunde, I. G. G., Hellebrekers, D. M. E. I., Claes, G. R. F., Wakimoto, H., Gorham, J., Krapels, I. P. C., Vanhoutte, E. K. K., van den Wijngaard, A., Henkens, M. T. H. M., Raafs, A. G. G., Sikking, M. A. A., Broers, J. L. V., Nabben, M., Jones, E. A. V., Heymans, S. R. B., Brunner, H. G. G., & Verdonschot, J. A. J. (2023). Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(2), Article e003788. https://doi.org/10.1161/CIRCGEN.122.003788
    • Ferreira, J. P., Cleland, J. G. F., Girerd, N., Pellicori, P., Hazebroek, M. R., Verdonschot, J., Collier, T. J., Petutschnigg, J., Clark, A. L., Staessen, J. A., Heymans, S., Rossignol, P., & Zannad, F. (2023). Effect of Spironolactone on QRS Duration in Patients at Risk for Heart Failure (from the HOMAGE Trial). American Journal of Cardiology, 191(1), 39-42. https://doi.org/10.1016/j.amjcard.2022.12.016
    • Robinson, E. L., Ameri, P., Delrue, L., Vanderheyden, M., Bartunek, J., Altieri, P., Heymans, S., & Heggermont, W. A. (2023). Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity. Frontiers in Cardiovascular Medicine, 10(1), Article 884174. https://doi.org/10.3389/fcvm.2023.884174
    • Ferreira, J. P., Cleland, J. G. F., Girerd, N., Pellicori, P., Hazebroek, M. R., Verdonschot, J., Collier, T. J., Petutschnigg, J., Clark, A. L., Staessen, J. A., Heymans, S., Zannad, F., & Rossignol, P. (2023). Early and late renal function changes with spironolactone in patients at risk of developing heart failure: findings from the HOMAGE trial. Clinical research in cardiology, 112(2), 330-332. https://doi.org/10.1007/s00392-022-02116-w
    • Nuzzi, V., Raafs, A., Manca, P., Henkens, M. T. H. M., Gregorio, C., Boscutti, A., Verdonschot, J., Hazebroek, M., Knackstedt, C., Merlo, M., Stolfo, D., Sinagra, G., & Heymans, S. R. B. (2023). Left Atrial Reverse Remodeling in Dilated Cardiomyopathy. Journal of the American Society of Echocardiography, 36(2), 154-162. https://doi.org/10.1016/j.echo.2022.10.017
    • van Beek, D., Verdonschot, J., Derks, K., Brunner, H., de Kok, T., Arts, I., Heymans, S., Kutmon, M., & Adriaens, M. (2023). Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort. Scientific Reports, 13(1), Article 564. https://doi.org/10.1038/s41598-023-27591-7
  • 2022
    • Rypdal, K. B., Olav Melleby, A., Robinson, E. L., Li, J., Palmero, S., Seifert, D. E., Martin, D., Clark, C., López, B., Andreassen, K., Dahl, C. P., Sjaastad, I., Tønnessen, T., Stokke, M. K., Louch, W. E., González, A., Heymans, S., Christensen, G., Apte, S. S., & Lunde, I. G. (2022). ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Communications Biology, 5(1), Article 1392. https://doi.org/10.1038/s42003-022-04361-1
    • Fanti, S., Stephenson, E., Rocha-Vieira, E., Protonotarios, A., Kanoni, S., Shahaj, E., Paula Longhi, M., Vyas, V. S., Dyer, C., Pontarini, E., Asimaki, A., Bueno-Beti, C., De Gaspari, M., Rizzo, S., Basso, C., Bombardieri, M., Coe, D., Wang, G., Harding, D., ... Marelli-Berg, F. M. (2022). Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity. Circulation, 146(25), 1930-1945. https://doi.org/10.1161/CIRCULATIONAHA.121.055610
    • van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., ... Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016-3051. https://doi.org/10.1093/cvr/cvab370
    • Monzo, L., Ferreira, J. P., Cleland, J. G. F., Pellicori, P., Mariottoni, B., Hazebroek, M. R., Collier, T. J., Cuthbert, J. J., Pieske, B., Petutschnigg, J., Ahmed, F. Z., Girerd, N., Clark, A. L., Cosmi, F., Staessen, J. A., Heymans, S., Rossignol, P., & Zannad, F. (2022). Dyskalemia in people at increased risk for heart failure: findings from the heart 'OMics' in AGEing (HOMAGE) trial. Esc heart failure, 9(6), 4352-4357. https://doi.org/10.1002/ehf2.14086
    • Carai, P., Florit González, L., Van Bruggen, S., Spalart, V., De Giorgio, D., Geuens, N., Martinod, K., Jones, E. A. V., & Heymans, S. (2022). NEUTROPHIL INHIBITION IMPROVES ACUTE INFLAMMATION IN A MURINE MODEL OF VIRAL MYOCARDITIS. Cardiovascular Research, 118(17), 3331-3345. https://doi.org/10.1093/cvr/cvac052
    • Suresh Babu, V., Kizhakeyil, A., Dudeja, G., Chaurasia, S. S., Barathi, V. A., Heymans, S., Verma, N. K., Lakshminarayanan, R., & Ghosh, A. (2022). Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial Dodecapeptides. Pharmaceutics, 14(11), Article 2507. https://doi.org/10.3390/pharmaceutics14112507
    • Xu, L., Balzarolo, M., Robinson, E. L., Lorenz, V., Verde, G. D., Joray, L., Mochizuki, M., Kaufmann, B. A., Valstar, G., de Jager, S. C. A., den Ruijter, H. M., Heymans, S., Pfister, O., & Kuster, G. M. (2022). NOX1 mediates metabolic heart disease in mice and is upregulated in monocytes of humans with diastolic dysfunction. Cardiovascular Research, 118(14), 2973-2984. https://doi.org/10.1093/cvr/cvab349
    • Remmelzwaal, S., van Oort, S., Handoko, M. L., van Empel, V., Heymans, S. R. B., & Beulens, J. W. J. (2022). Inflammation and heart failure: a two-sample Mendelian randomization study. Journal of Cardiovascular Medicine, 23(11), 728-735. https://doi.org/10.2459/JCM.0000000000001373
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