Publications
- 2010
- Laeremans, H., Rensen, S. S. M., Ottenheijm, H. C. J., Smits, J. F. M., & Blankesteijn, W. M. (2010). Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovascular Research, 87(3), 514-523. https://doi.org/10.1093/cvr/cvq067
- Martins, P. A. D. C., Leptidis, S., Salic, K., & De Windt, L. J. (2010). MicroRNA Regulation in Cardiovascular Disease. Current Drug Targets, 11(8), 900-906. https://doi.org/10.2174/138945010791591322
- Cosemans, J. M. E. M., Van Kruchten, R., Olieslagers, S., Schurgers, L. J., Verheyen, F. K., Munnix, I. C. A., Waltenberger, J., Angelillo-Scherrer, A., Hoylaerts, M. F., Carmeliet, P., & Heemskerk, J. W. M. (2010). Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. Journal of Thrombosis and Haemostasis, 8(8), 1797-1808. https://doi.org/10.1111/j.1538-7836.2010.03935.x
- Storkebaum, E., de Almodovar, C. R., Meens, M., Zacchigna, S., Mazzone, M., Vanhoutte, G., Vinckier, S., Miskiewicz, K., Poesen, K., Lambrechts, D., Janssen, G. M. J., Fazzi, G. E., Verstreken, P., Haigh, J., Schiffers, P. M., Rohrer, H., Van Der Linden, A., De Mey, J. G. R., & Carmeliet, P. (2010). Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery. Circulation, 122(3), 273-U107. https://doi.org/10.1161/CIRCULATIONAHA.109.929364
- Mensink, R. P., Jong, A., Lutjohann, D., Haenen, G. R. M., & Plat, J. (2010). Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. American Journal of Clinical Nutrition, 92(1), 24-33. https://doi.org/10.3945/ajcn.2009.29143
- Meens, M. J. P. M. T., Compeer, M. G., Hackeng, T. M., van Zandvoort, M. A., Janssen, B. J. A., & De Mey, J. G. R. (2010). Stimuli of Sensory-Motor Nerves Terminate Arterial Contractile Effects of Endothelin-1 by CGRP and Dissociation of ET-1/ETA-Receptor Complexes. PLOS ONE, 5(6), 11. https://doi.org/10.1371/journal.pone.0010917
- Nawrot, T. S., Staessen, J. A., Holvoet, P., Struijker-Boudier, H. A., Schiffers, P., Van Bortel, L. M., Fagard, R. H., Gardner, J. P., Kimura, M., & Aviv, A. (2010). Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking. Frontiers in Bioscience, Elite edition, 2(3), 1164-1168. https://doi.org/10.2741/E176
- Hemery, Y. M., Anson, N. M., Havenaar, R., Haenen, G. R. M. M., Noort, M. W. J., & Rouau, X. (2010). Dry-fractionation of wheat bran increases the bioaccessibility of phenolic acids in breads made from processed bran fractions. Food Research International, 43(5), 1429-1438. https://doi.org/10.1016/j.foodres.2010.04.013
- Kuster, G. M., Nietlispach, F., Kiowski, W., Schindler, R., Bernheim, A. M., Schuetz, P., Mueller, B., Morgenthaler, N. G., Rueter, F., Riesen, W., Rickli, H., & Brunner-La Rocca, H. P. (2010). Role of RAS Inhibition in the Regulation of Cu/Zn-SOD in the Cardiac and Peripheral Arterial Beds in Humans. Clinical Pharmacology & Therapeutics, 87(6), 686-692. https://doi.org/10.1038/clpt.2010.36
- Brouwers, O., Niessen, P. M., Haenen, G. R. M. M., Miyata, T., Brownlee, M., Stehouwer, C. D. A., de Mey, J. G. R., & Schalkwijk, C. G. (2010). Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.Diabetologia, 53(5), 989-1000. https://doi.org/10.1007/s00125-010-1677-0
- Tijsen, A. J., Creemers, E. E., Moerland, P. D., de Windt, L. J., van der Wal, A. C., Kok, W. E., & Pinto, Y. M. (2010). MiR423-5p As a Circulating Biomarker for Heart Failure. Circulation Research, 106(6), 1035-U63. https://doi.org/10.1161/CIRCRESAHA.110.218297
- van Oort, R. J., Respress, J. L., Li, N., Reynolds, C., De Almeida, A. C., Skapura, D. G., De Windt, L. J., & Wehrens, X. H. T. (2010). Accelerated Development of Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model. Hypertension, 55(4), 932-U216. https://doi.org/10.1161/HYPERTENSIONAHA.109.146449
- Muzzarelli, S., Brunner-La Rocca, H., Pfister, O., Foglia, P., Moschovitis, G., Mombelli, G., & Stricker, H. (2010). Adherence to the medical regime in patients with heart failure. European journal of heart failure, 12(4), 389-396. https://doi.org/10.1093/eurjhf/hfq015
- Verkaar, F., Blankesteijn, W. M., Smits, J. F. M., & Zaman, G. J. R. (2010). beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling. Faseb Journal, 24(4), 1205-1217. https://doi.org/10.1096/fj.09-141671
- McCurdy, S., Baicu, C. F., Heymans, S., & Bradshaw, A. D. (2010). Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). Journal of Molecular and Cellular Cardiology, 48(3), 544-549. https://doi.org/10.1016/j.yjmcc.2009.06.018
- Schalla, S., Bekkers, S. C., Dennert, R., van Suylen, R. J., Waltenberger, J., Leiner, T., Wildberger, J., Crijns, H. J., & Heymans, S. (2010). Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy. European journal of heart failure, 12(3), 227-231. https://doi.org/10.1093/eurjhf/hfq004
- Vanhoutte, D., & Heymans, S. (2010). TIMPs and cardiac remodeling: 'Embracing the MMP-independent-side of the family'. Journal of Molecular and Cellular Cardiology, 48(3), 445-453. https://doi.org/10.1016/j.yjmcc.2009.09.013
- Kriemler, S., Zahner, L., Schindler, C., Meyer, U., Hartmann, T., Hebestreit, H., Brunner-La Rocca, H. P., van Mechelen, W., & Puder, J. J. (2010). Effect of school based physical activity programme (KISS) on fitness and adiposity in primary schoolchildren: cluster randomised controlled trial. BMJ, 340, 8. https://doi.org/10.1136/bmj.c785
- Beljaars, C. P., Balk, J. M., Bast, A., & Haenen, G. R. (2010). Prevention of a systematic underestimation of antioxidant activity in competition assays. The impact of unspecific reactions of the reactive species.Biochemical and Biophysical Research Communications, 392(3), 346-350. https://doi.org/10.1016/j.bbrc.2010.01.022
- Post, S., Smits, A. M., van den Broek, A. J., Sluijter, J. P. G., Hoefer, I. E., Janssen, B. J., Snijder, R. J., Mager, J. J., Pasterkamp, G., Mummery, C. L., Doevendans, P. A., & Goumans, M.-J. (2010). Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance. Cardiovascular Research, 85(3), 494-502. https://doi.org/10.1093/cvr/cvp313
- Schellings, M. W. M., Vanhoutte, D., van Almen, G. C., Swinnen, M., Leenders, J. J. G., Kubben, N., van Leeuwen, R. E. W., Hofstra, L., Heymans, S., & Pinto, Y. M. (2010). Syndecan-1 Amplifies Angiotensin II-Induced Cardiac Fibrosis. Hypertension, 55(2), 249-U87. https://doi.org/10.1161/HYPERTENSIONAHA.109.137885
- Dennert, R. M., van Paassen, P., Schalla, S., Kuznetsova, T., Alzand, B. S. N., Staessen, J. A., Velthuis, S., Crijns, H. J., Tervaert, J. W. C., & Heymans, S. (2010). Cardiac Involvement in Churg-Strauss Syndrome. Arthritis & Rheumatism, 62(2), 627-634. https://doi.org/10.1002/art.27263
- van Rooij, E., Fielitz, J., Sutherland, L. B., Thijssen, V. L., Crijns, H. J., Dimaio, M. J., Shelton, J., De Windt, L. J., Hill, J. A., & Olson, E. N. (2010). Myocyte Enhancer Factor 2 and Class II Histone Deacetylases Control a Gender-Specific Pathway of Cardioprotection Mediated by the Estrogen Receptor. Circulation Research, 106(1), 155-U315. https://doi.org/10.1161/CIRCRESAHA.109.207084
- Lenaers, E., Feyter, H. M., Hoeks, J., Schrauwen, P., Schaart, G., Nabben, M., Nicolay, K., Prompers, J. J., & Hesselink, M. K. (2010). Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.Obesity, 18(6), 1100-1107. https://doi.org/10.1038/oby.2009.372
- Jacobs, H., Moalin, M., Bast, A., van der Vijgh, W. J., & Haenen, G. R. M. M. (2010). An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network. PLOS ONE, 5(11), Article e13880. https://doi.org/10.1371/journal.pone.0013880
- Bartholomé, R., Haenen, G. R. M. M., Hollman, C. H., Bast, A., Dagnelie, P. C., Roos, D., Keijer, J., Kroon, P. A., Needs, P. W., & Arts, C. W. (2010). Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by beta-glucuronidase from Neutrophils. Drug metabolism and pharmacokinetics, 25(4), 379-87. https://doi.org/10.2133/dmpk.DMPK-10-RG-002
- den Hartog, G. J., Boots, A. W., Adam Perrot, A., Brouns, F. J. P. H., Verkooijen, I. W., Weseler, A. R., Haenen, G. R., & Bast, A. (2010). Erythritol is a sweet antioxidant. Nutrition, 26(4), 449-458. https://doi.org/10.1016/j.nut.2009.05.004
- Gungor, N., Knaapen, A. M., Munnia, A., Peluso, M., Haenen, G. R., Chiu, R. K., Godschalk, R. W., & van Schooten, F. J. (2010). Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis, 25(2), 149-154. https://doi.org/10.1093/mutage/gep053
- Bast, A., Weseler, A. R., Haenen, G. R. M. M., & den Hartog, G. J. M. (2010). Oxidative stress and antioxidants in interstitial lung disease.Current Opinion in Pulmonary Medicine, 16(5), 516-520. https://doi.org/10.1097/MCP.0b013e32833c645d
- Wijnen, P. A., Linssen, C. F., Haenen, G. R., Bekers, O., & Drent, M. (2010). Variant VKORC1 and CYP2C9 Alleles in Patients with Diffuse Alveolar Hemorrhage Caused by Oral Anticoagulants. Molecular Diagnosis & Therapy, 14(1), 23-30. https://doi.org/10.1007/BF03256350
- Anson, N. M., Havenaar, R., Bast, A., & Haenen, G. R. M. M. (2010). Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion. Journal of Cereal Science, 51(1), 110-114. https://doi.org/10.1016/j.jcs.2009.10.005
- PROTECT Steering Committee, & Heymans, S. (2010). Design and Rationale of the PROTECT Study: A Placebo-controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function. Journal of Cardiac Failure, 16(1), 25-35. https://doi.org/10.1016/j.cardfail.2009.10.025
- el Azzouzi, H., van Oort, R. J., van der Nagel, R., Sluiter, W., Bergmann, M. W., & De Windt, L. J. (2010). MEF2 transcriptional activity maintains mitochondrial adaptation in cardiac pressure overload. European journal of heart failure, 12(1), 4-12. https://doi.org/10.1093/eurjhf/hfp165
- van den Borne, S. W. M., Diez, J., Blankesteijn, W. M., Verjans, J., Hofstra, L., & Narula, J. (2010). Myocardial remodeling after infarction: the role of myofibroblasts. Nature Reviews Cardiology, 7(1), 30-37. https://doi.org/10.1038/nrcardio.2009.199
- Dennert, R., Velthuis, S., Schalla, S., Eurlings, L. W., van Suylen, R.-J., van Paassen, P., Tervaert, J. W. C., Wolffs, P., Goossens, V. J., Bruggeman, C., Waltenberger, J., Crijns, H. J., & Heymans, S. (2010). Intravenous immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial biopsy-proven high PVB19 viral load. Antiviral Therapy, 15(2), 193-201. https://doi.org/10.3851/IMP1516
- Megens, R. T. A., Reitsma, S., Prinzen, L., Egbrink, M. G. A. O., Engels, W., Leenders, P. J. A., Brunenberg, E. J. L., Reesink, K. D., Janssen, B. J. A., Romeny, B. M. T. H., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2010). In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy. Journal of Biomedical Optics, 15(1), 10. Article 011108. https://doi.org/10.1117/1.3281672
- Dennert, R., Velthuis, S., Westermann, D., Donker, D. W., Schalla, S., van Suylen, R.-J., & Heymans, S. (2010). Parvovirus-B19-associated fulminant myocarditis successfully treated with immunosuppressive and antiviral therapy. Antiviral Therapy, 15(4), 681-685. https://doi.org/10.3851/IMP1563
- 2009
- de Jongh, R., Dambros, M., Haenen, G. R., den Hartog, G. J., Bast, A., van Kerrebroeck, P. E., & van Koeveringe, G. A. (2009). Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder. Neurourology and Urodynamics, 28(5), 461-467. https://doi.org/10.1002/nau.20677
- Boots, A. W., Drent, M., Swennen, E. L., Moonen, H. J., Bast, A., & Haenen, G. R. (2009). Antioxidant status associated with inflammation in sarcoidosis: A potential role for antioxidants. Respiratory Medicine, 103(3), 364-372. https://doi.org/10.1016/j.rmed.2008.10.007
- Boots, A. W., Hristova-Dijkstra, M. J., Kasahara, D. I., Haenen, G. R., Bast, A., & van der Vliet, A. (2009). ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.Journal of Biological Chemistry, 284(26), 17858-17867. https://doi.org/10.1074/jbc.M809761200
- Mateo Anson, N., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. (2009). Bioavailability of ferulic acid is determined by its bioaccessibility. Journal of Cereal Science, 49(2), 296-300. https://doi.org/10.1016/j.jcs.2008.12.001
- Mateo Anson, N., Selinheimo, E., Havenaar, R., Aura, A. M., Mattila, I., Lehtinen, P., Bast, A., Poutanen, K., & Haenen, G. R. (2009). Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds.Journal of Agricultural and Food Chemistry, 57(14), 6148-6155. https://doi.org/10.1021/jf900492h
- Jacobs, H., van der Vijgh, W. J., Koek, G. H., Draaisma, G. J., Moalin, M., van Strijdonck, G. P., Bast, A., & Haenen, G. R. (2009). Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER. Free Radical Biology and Medicine, 46(12), 1567-1573. https://doi.org/10.1016/j.freeradbiomed.2009.02.031
- Balk, J. M., Bast, A., & Haenen, G. R. (2009). Evaluation of the accuracy of antioxidant competition assays: incorrect assumptions with major impact.Free Radical Biology and Medicine, 47(2), 135-144. https://doi.org/10.1016/j.freeradbiomed.2009.04.009
- 2008
- Mateo Anson, N., van den Berg, R., Havenaar, R., Haenen, G. R., & Bast, A. (2008). Antioxidant and anti-inflammatory potency of different wheat varieties and fractions. Proceedings of the Nutrition Society, 67(OCE1), Article E56. https://doi.org/10.1017/S0029665108006654
- Mateo Anson, N., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. M. (2008). Ferulic Acid from Aleurone Determines the Antioxidant Potency of Wheat Grain (Triticum aestivum L.). Journal of Agricultural and Food Chemistry, 56(14), 5589-5594. https://doi.org/10.1021/jf800445k
- Boots, A. W., Haenen, G. R., & Bast, A. (2008). Health effects of quercetin: from antioxidant to nutraceutical.European Journal of Pharmacology, 585(2-3), 325-337. https://doi.org/10.1016/j.ejphar.2008.03.008
- Boots, A., Wilms, L. C., Swennen, E. L., Kleinjans, J. C., Bast, A., & Haenen, G. R. (2008). In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition, 24(7-8), 703-10. https://doi.org/10.1016/j.nut.2008.03.023
- de Jongh, R., Haenen, G. R. M. M., van Koeveringe, G. A., Dambros, M., & van Kerrebroeck, P. E. V. (2008). Lipid peroxidation product 4-hydroxynonenal contributes to bladder smooth muscle damage.Urology, 71(5), 974-978. https://doi.org/10.1016/j.urology.2007.11.014
- Hoeks, J., Briede, J. J., de Vogel, J., Schaart, G., Nabben, M., Kornips, E., Hesselink, M. K., & Schrauwen, P. (2008). Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding. Febs Letters, 582(4), 510-6. https://doi.org/10.1016/j.febslet.2008.01.013